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Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

A high-risk perioperative atrial fibrillation phenotype and early outcomes after isolated coronary artery bypass grafting.

Khalil E, Yüksel B · 2026 · Archives of medical sciences. Atherosclerotic diseases

Introduction Perioperative atrial fibrillation (POAF) remains the most common arrhythmic complication occurring in the setting of isolated coronary artery bypass grafting (CABG), and it is now being increasingly recognised as a marker of…

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Negative / Null Result ReportOpen accessMedicine

Association between Levels of Alcohol Use, Perceived HIV Risk, and Untreated HIV Among Persons at Alcohol-Serving Venues in Kenya and Uganda.

Beesiga B, Litunya J, Nakato JZ et al. · 2026 · AIDS and behavior

Alcohol-serving venues in East Africa are high-risk environments for HIV transmission but few studies in sub-Saharan Africa (SSA) have examined perceived HIV risk and sexual risk behaviors by alcohol use levels on a broader population of…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of Emotion-Focused Cognitive Behaviour Therapy on Emotional Hyporexia Among Adolescent Girls with Eating Problems: A Pilot Study.

Shinde SS, Naik NS, Adhyapak SU et al. · 2025 · Journal of pharmacy & bioallied sciences

Background Emotional hyporexia, a form of intentional food avoidance triggered by emotional distress, presents a growing health concern among adolescent girls. Addressing this behavior through psychological intervention is essential for…

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Negative / Null Result ReportOpen accessMedicine

A Longitudinal Observational Study on Lactation-Associated Changes in Procalcitonin, Protein Carbonyl Content, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Dairy Cattle.

Sala G, Castelli M, Orsetti C et al. · 2025 · Veterinary sciences

Procalcitonin (PCT), protein carbonyl content (PCC), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been proposed as promising biomarkers for detecting diseases in cattle. Their concentrations could…

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Negative / Null Result ReportOpen accessMedicine

Influence of Coagulation Factor VIII on Ischemic Stroke.

Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P et al. · 2026 · Revista de neurologia

Background There is considerable interest in the underlying mechanisms of cryptogenic stroke, with hypercoagulable states being widely studied. An elevated level of Factor VIII has been proposed as a potential prothrombotic marker…

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Negative / Null Result ReportOpen accessMedicine

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.

Cigarán-Méndez M, de-la-Llave-Rincón AI, Pacho-Hernández JC et al. · 2026 · International journal of molecular sciences

The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in…

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Negative / Null Result ReportMedicine

Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial.

Indraccolo S, Signoriello S, Piga I et al. · 2024 · The International journal of biological markers

Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic…

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Negative / Null Result ReportOpen accessMedicine

Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes.

Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…

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Negative / Null Result ReportMedicine

Assessment of the impact of microplastic ingestion in striped red mullets from an Eastern Mediterranean coastal area (Zakynthos Island, Ionian Sea).

Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research

Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…

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Negative / Null Result ReportOpen accessMedicine

A case-control study on the diagnostic role of Omega-3 fatty acid levels in erythrocyte membranes of critically ill patients.

Dorchin M, Nasiri-Jounaghani M, Hashemi-Javaheri FS et al. · 2025 · Scientific reports

This study aimed to investigate the erythrocyte Omega-3 fatty acid index as a potential biomarker for clinical severity, nutritional status, and mortality risk in critically ill patients admitted to the intensive care unit (ICU). Using a…

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Negative / Null Result ReportMedicine

Effectiveness of a School-Based Substance Use Prevention Program in Reducing Primary School Students' Intentions to Use Tobacco, Alcohol or Other Drugs in the Future.

Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…

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Negative / Null Result ReportMedicine

Age-related changes and lack of effect of midlife resistance wheel exercise on afferent connectivity of lumbar alpha motor neurons in ageing mouse spinal cord.

S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology

This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…

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Negative / Null Result ReportMedicine

Percutaneous gastrostomy, mechanical ventilation and survival in amyotrophic lateral sclerosis: an observational study in an incident cohort.

Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…

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Negative / Null Result ReportMedicine

Triiodothyronine supplementation in a sheep model of intensive care.

Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine

Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…

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Negative / Null Result ReportMedicine

Challenges and lessons learned in attempts to develop in vitro models for ultrasound neuromodulation using local field potential measurements in hippocampal tissue.

Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal

Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…

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Negative / Null Result ReportMedicine

Pumping Behaviors of Breast Pump-Dependent Mothers of Preterm Infants in the Neonatal Intensive Care Unit (NICU): Importance of the First Five Postpartum Days.

Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…

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Negative / Null Result ReportMedicine

Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B<sup>-/-</sup> mice via the CREB/BDNF pathway.

Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology

Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…

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