21,742 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Riancho-Zarrabeitia L, Barrena OI, Santos-Gomez M et al. · 2026 · Reumatologia clinica
Background/objectives Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease marked by diverse autoantibodies. While serological clusters have been associated with distinct clinical phenotypes, most existing studies rely…
View details →Bonthrone AF, Cromb D, Javed SA et al. · 2026 · Placenta
Objectives To assess if maternal stress is higher in pregnancies with congenital heart disease (CHD) compared to low-risk pregnancies and if maternal stress is associated with placental microstructure and function. To explore if CHD alters…
View details →Pagano R, Kruashvili L, Puchalska M et al. · 2026 · Preprint
ABSTRACT Alcohol craving and consumption fluctuate across the reproductive cycle in females with alcohol use disorder (AUD), suggesting that estrogen signaling contributes to disease vulnerability. Here, we investigated the role of…
View details →Li J, de Vries HD, Ustyantsev K et al. · 2026 · Journal of lipid research
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
View details →Kirk C, Smith E, Wozniak A et al. · 2026 · Cutaneous and ocular toxicology
Purpose Emerging evidence supports a protective role of statins at preventing the progression of early-intermediate stage non-neovascular (dry) AMD. Clinical findings, however, remain equivocal as to the beneficial effects of statin use…
View details →Mattke AC, Schlapbach LJ, Takashima M et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow…
View details →Gu C, Xu R, Yin B et al. · 2025 · Integrative zoology
Predator cues have profound impacts on the behavior and physiology of prey animals. However, the mechanisms underlying stress responses induced by chronic exposure to predator cues in mammals, particularly the role of the gut microbiota,…
View details →Luo Y, Wei K · 2026 · Experimental brain research
Motor adaptation arises from multiple learning mechanisms, including use-dependent learning (UDL) driven by repetition and implicit error-based learning (EBL) driven by motor prediction errors. Although both mechanisms contribute…
View details →Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
View details →Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
View details →Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
View details →Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
View details →Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
View details →Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
View details →Dantas MCDS, Moreira SDNT, Pinto Júnior FEL · 2026 · Journal of cancer education : the official journal of the American Association for Cancer Education
Background Communication of difficult news is a core competency in oncology education. How accurately medical students self-assess their communication performance shapes formative learning and curriculum design. Purpose To examine…
View details →Butzlaff R, Christoph C, Puhl L et al. · 2026 · Journal of psychosomatic research
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising non-pharmacological approach for postoperative pain management, but its interaction with childhood trauma (CT) remains unclear. This three-armed randomized…
View details →Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayón F · 2026 · Preprint
Abstract Rationale: Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive…
View details →Barris CT, Kress TC, Antonova G et al. · 2025 · American journal of physiology. Heart and circulatory physiology
The global rise in obesity parallels the increasing rates of hypertension and cardiovascular disease (CVD). These trends, and recent clinical and experimental data, have revealed that obesity abolishes the protection from CVD typically…
View details →Both A, Chevalier C, Connor MG et al. · 2026 · Preprint
Crosstalk between respiratory bacteria and human airway epithelial cells initiates cellular immunity, yet the molecular determinants of asymptomatic carriage versus inflammation remain incompletely understood. A key regulator of airway…
View details →Souza VKB, Ferreira DA, Arantes APR et al. · 2026 · Cell biochemistry and biophysics
Chronic neuroinflammation contributes to neuronal damage through oxidative stress and inflammatory mediators, highlighting the need for novel therapeutic strategies. This study evaluated the cytotoxicity and neuroprotective effects of…
View details →Litif C, Libster AM, Desfor S et al. · 2026 · Preprint
The Reln gene encodes the extracellular glycoprotein Reelin that regulates synaptic plasticity and activity-dependent gene expression with implications in several neuropsychiatric disorders, including substance use disorder. While reduced…
View details →Anwar S, Ebrahimi-Iranpour S, Huq S et al. · 2025 · Preprint
Lysosomes are organelles responsible for degrading unwanted extracellular material that cells internalize, or intracellular material targeted for disposal. Typically, lysosomes are globular in morphology. However, in activated macrophages…
View details →Shim HG, Fanning AS, Raymond JL · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
It is increasingly recognized that learning and memory depend not only on changes in synaptic strength but also on experience-dependent modifications of intrinsic neuronal excitability. However, how these two forms of plasticity interact…
View details →Acton JP, Alsharif NS, Bond JW et al. · 2026 · European journal of applied physiology
Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or…
View details →Su Y, Hu Q, Dou Z et al. · 2026 · Food research international (Ottawa, Ont.)
κ-Carrageenase with alkaline resistance can promote the resource utilization of κ-carrageenan industrial residues. In this study, a rational design strategy integrating surface charge optimization and consensus sequence analysis was…
View details →Hosny R, Saad M, Shebl R et al. · 2026 · Emergency radiology
PURPOSE: To evaluate the necessity of computed tomography (CT) in open globe injuries after ophthalmological assessment in the emergency department (ED) prior to primary repair. METHODS: A review of the medical records of patients…
View details →Hofbauer LM, Rodriguez FS · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
PurposeThis study examined whether different types of help received influence subsequent levels of functional ability in older adults.MethodsLongitudinal data were drawn from the US Health and Retirement Study (HRS), the Survey of Health,…
View details →Rees M, Vieira F, Yarragudi SB et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
Nasal high flow (NHF) with the asymmetrical cannula interface (AI) is increasingly used as respiratory support across a broad range of patients. By incorporating one unilaterally oversized prong, the AI enhances dead-space clearance and…
View details →Kagota S, Maruyama-Fumoto K, Niki A et al. · 2026 · Metabolic syndrome and related disorders
Background Perivascular adipose tissue (PVAT), found outside blood vessels, enhances vasorelaxation when endothelium-mediated vasorelaxation fails, as observed in the mesenteric arteries of rats with metabolic syndrome (MetS) and…
View details →Yadav P, Hamrahian AH, Salvatori R · 2026 · Pituitary
PURPOSE: Macimorelin, a ghrelin receptor agonist, is used for diagnosing adult GH deficiency (AGHD). The FDA-approved GH cut-off is 2.8 ng/mL, whereas post-hoc analyses proposed a cut-off of 5.1 ng/mL. The real-world performance of these…
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