Mice with humanized FXR ligand-binding domain display distinct metabolic responses upon pharmacological FXR stimulation.
Li J; de Vries HD; Ustyantsev K; Hovingh MV; Mulder NL; Havinga R; Huijkman N; Falcone S · 2026 · Journal of lipid research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
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Metadata source: Europe PMC · DOI 10.1016/j.jlr.2026.101088