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WASTE Journal

Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Multicenter phase 2 study of intrapleural nivolumab in patients with metastatic non-small cell lung cancer and pleural effusion.

Tsimafeyeu I, Goutnik V, Shrainer I et al. · 2023 · American journal of cancer research

About 40% of patients with non-small cell lung cancer (NSCLC) developed pleural effusions at some time during the course of their disease. Preliminary results from our Phase 2 multicentre clinical trial (Cohort 1) demonstrated the safety…

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Negative / Null Result ReportOpen accessMedicine

Real-world outcomes in patients with brain metastases secondary to HR+/HER2- MBC treated with abemaciclib and local intracranial therapy.

Gathirua-Mwangi W, Martin H, He D et al. · 2025 · The oncologist

Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients…

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Failed Experiment ReportMedicine

Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 trial.

Paz-Ares L, Goto Y, Wan-Teck Lim D et al. · 2024 · Lung cancer (Amsterdam, Netherlands)

Objectives Canakinumab, an interleukin-1 beta inhibitor, previously showed reduced lung cancer incidence and mortality (CANTOS). Here, we compare the efficacy/safety of canakinumab versus placebo in patients with advanced non-small cell…

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Negative / Null Result ReportMedicine

Differential effects of hypothalamic ET<sub>B</sub> receptor blockade in fever, hypolocomotion and serotonin release during systemic inflammation in male and female rats.

Alencar TS, Santos MO, Schneider VMM et al. · 2026 · Brain research

Systemic inflammation triggers a set of physiological and behavioral changes known as sickness behavior, including fever and hypolocomotion. Previous studies demonstrated that lipopolysaccharide (LPS) induces these responses in both sexes,…

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Negative / Null Result ReportOpen accessMedicine

Exhausted olive pomace as a replacement for soybean hulls in corn silage-based diets for late-lactating Holstein cows: Insights from sustainable dairy farming.

Fonseca AJM, Cabrita ARJ · 2026 · JDS communications

This study evaluated the effects of replacing soybean hulls with exhausted olive pomace (EOP) on feed intake, milk production and composition, and rumen fermentation parameters. A cyclical changeover design experiment was used with 4…

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Negative / Null Result ReportMedicine

Revisiting hypocholesterolemia during prolonged sepsis: From targeted cholesterol repletion to unresolved adrenal and muscle dysfunction.

De Bruyn L, Van Beek F, Vander Perre S et al. · 2026 · Molecular and cellular endocrinology

Background Sepsis HDL- and LDL-hypocholesterolemia associate with adverse outcomes, but whether this necessitates supplementation or merely reflects disease severity remains unclear. We hypothesize that sustained hypocholesterolemia can…

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Negative / Null Result ReportMedicine

Effect of different vaccination schedules and administration of a nonsteroidal anti-inflammatory drug around dry-off on inflammation, immunity, and performance of dairy cows.

Gao J, Savegnago CG, Marins TN et al. · 2026 · Journal of dairy science

This study evaluated the effects of different vaccination schedule and oral administrating a nonsteroidal anti-inflammatory drug (NSAID) around dry-off on systemic inflammation, immune responses, behaviors during the early dry period, and…

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Negative / Null Result ReportMedicine

A Performance Evaluation of Bayesian Forecasting for Serum Linezolid Concentrations: Impact of Clinical Factors on Prediction Accuracy.

Hashimoto N, Wakimoto Y, Kusama T et al. · 2026 · Therapeutic drug monitoring

Background Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent data set with a…

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Negative / Null Result ReportMedicine

Copper regulates the synthesis of steroid hormones through CCS and ATOX1 dependent MEK1-ERK1/2 pathway in follicular granulosa cells of yak (Bos grunniens).

Lou Y, Yang T, Xia C et al. · 2026 · Molecular and cellular endocrinology

Steroid hormone synthesis in granulosa cells (GCs) is crucial for normal follicular development and ovulation. Emerging evidence suggests that copper (Cu), a trace element, influences hormone secretion in yak granulosa cells (YGCs);…

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Negative / Null Result ReportMedicine

Effects of emamectin benzoate spiked sediment on adult, larval and post-larval stages of the American lobster (Homarus americanus).

Asnicar D, Jonah L, Kingsbury M et al. · 2026 · The Science of the total environment

Salmon farming represents a significant economic sector on both Canada's Atlantic and Pacific coasts. To manage sea lice outbreaks, medicated feeds containing emamectin benzoate (EMB) are commonly applied. Because EMB is poorly soluble and…

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Negative / Null Result ReportMedicine

Primary and steroid-induced antibody deficiency in severe asthma: a real-life analysis of a well-defined biologic-treated cohort.

Yegin Katran Z, Argın Ö, Bulut İ · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma

Background Severe asthma is frequently associated with recurrent exacerbations and prolonged systemic corticosteroid use, which may lead to secondary immunodeficiency (SID). In addition, unrecognized primary immunodeficiencies (PIDs) may…

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Negative / Null Result ReportMedicine

The effects of imidacloprid exposure on the mouse ovary in vivo.

Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)

Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…

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Negative / Null Result ReportMedicine

Post-COVID-19 diabetes outcomes.

Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports

Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…

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Negative / Null Result ReportMedicine

Physicochemical, rheological, textural, tribological, and sensory insights into the role of citrus fiber in quark cheese spreads with varying fat content.

Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science

The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…

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Negative / Null Result Report

Novel recombinant bovine papular stomatitis virus expressing foot and mouth disease virus-like particles elicits protective levels of neutralizing antibodies in cattle

Chambaro HM, Delhon G, Miraglia MC et al. · 2026 · Preprint

Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity, cold-chain dependence, and high-containment manufacturing. Here, we engineered a…

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Negative / Null Result ReportMedicine

Impact of formaldehyde application in commercial hatchers on chick intestinal microbiota.

Meisinger BD, Coufal CD, Olson EG et al. · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

Reducing microbial contamination during late-stage incubation is important for hatchery sanitation and early chick microbial exposure. Formaldehyde is commonly applied in commercial hatchers to reduce airborne and eggshell-associated…

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Negative / Null Result ReportMedicine

Nasal shedding of bovine coronavirus during commingling is associated with reduced average daily gain and lung lesions in weaned seropositive calves.

Urbaniec J, Anagnostopoulos A, Davies P et al. · 2026 · Journal of dairy science

Bovine coronavirus (BCV) is a common calf pathogen and has been proposed as a potential contributor to bovine respiratory disease (BRD); however, little is known about its epidemiology and genetic diversity on UK farms. The aim of this…

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