e-ISSN: Pending

Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Cryoprecipitate utilization in the neonatal intensive care unit: a single-center review.

Stoeckel, Soule-Albridge, Feldman et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Significant variability exists in the indications for and dosing of cryoprecipitate transfusions. We examined cryoprecipitate transfusions in neonates with a focus on indications, dosing, and the incidence of multi-donor exposure. In this…

View details →
Negative / Null Result ReportMedicine

Clinical correlates of ocular dominance in post-facial paralysis synkinesis.

Kapur, Henry, Lee et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

We aimed to explore the relationship between ocular dominance and synkinesis severity. Through phone interviews and a web-based survey, patients were asked to test their ocular dominance via the Miles test. Additionally, patients were…

View details →
Negative / Null Result ReportMedicine

Single anastomosis duodeno-ileal bypass with sleeve gastrectomy in the United States: has increased volume impacted safety?

Ballato, Shenoy, Le Gardeur De Tilly et al. · 2026 · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Originally described in 2007, the single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) was only endorsed by the American Society for Metabolic and Bariatric Surgery in 2020. Since then, the procedure has grown…

View details →
Negative / Null Result ReportMedicine

Difference in outcomes between right and left posterior descending artery percutaneous coronary intervention: an Australian statewide registry analysis.

Rahman Zahin, Batchelor, Brennan et al. · 2026 · The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

Percutaneous coronary intervention (PCI) is an important treatment for coronary artery disease, and coronary dominance may influence procedural risk. PCI to a left-sided posterior descending artery (L-PDA) occurs in the setting of…

View details →
Failed Experiment ReportMedicine

Survival Outcomes in Early Onset Appendiceal Adenocarcinoma (EOAA).

Gujarathi, Belmont, Rodman et al. · 2026 · Annals of surgical oncology

The incidence of early onset (age&#x2009;<&#x2009;50 years at diagnosis) appendiceal adenocarcinoma (EOAA) is rising alarmingly. Reported data on etiology, treatment, and outcomes is scarce. In this study, we report clinical outcomes for…

View details →
Failed Experiment ReportMedicine

Age-dependent alterations in anterior cingulate excitation-inhibition balance in major depressive disorder revealed by 7-Tesla magnetic resonance spectroscopy.

Yoshihara, Suwa, Kubota et al. · 2026 · NeuroImage. Clinical

Altered excitation-inhibition (E/I) balance has been implicated in the pathophysiology of major depressive disorder (MDD), but previous magnetic resonance spectroscopy (MRS) findings have been inconsistent, partly due to methodological…

View details →
Negative / Null Result ReportMedicine

Efficacy of a digitally designed anatomical repositioning splint for adolescent temporomandibular joint anterior disc displacement with reduction: a randomized controlled trial.

Wang, Wang, Wu et al. · 2026 · BMC oral health

Anterior disc displacement with reduction (ADDwR) is a common temporomandibular joint disorder in adolescents. Conventional anterior repositioning splints (ARS) often lack anatomical adaptation, which may limit their therapeutic precision…

View details →
Negative / Null Result ReportMedicine

Does Tibial Tunnel Placement Affect Postoperative Function and Isokinetic Outcomes in Patients Undergoing Anatomical Single-Bundle Anterior Cruciate Ligament Reconstruction with Hamstring Autograft?

Arslanta&#x15f;, Deveci, Ozdemir et al. · 2026 · The journal of knee surgery

Tunnel malposition is a frequent complication of anterior cruciate ligament (ACL) reconstruction. We evaluated whether the tibial tunnel location of patients who underwent anatomical single-bundle ACL reconstruction with hamstring tendons…

View details →
Negative / Null Result ReportMedicine

Comparison of early-onset and average-onset colorectal cancer in Saudi Arabia: A multicenter retrospective cohort study.

Alessy, Al-Bawardy, Alabdullah et al. · 2026 · Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Although overall colorectal cancer (CRC) incidence has stabilized or declined in some regions, early-onset CRC (EO-CRC) is increasing in many countries. We aimed to compare EO-CRC with average-onset CRC (AO-CRC) to inform screening and…

View details →
Negative / Null Result ReportMedicine

Stool Microbiota, Metabolites, and Fecal Incontinence in Women.

Arya, Kashyap, Carnes et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Stool metabolites influencing gut motility and sensation may contribute to fecal incontinence (FI). The objective of this study was to test whether FI is associated with higher levels of butyrate and Clostridiales taxa in stool. Stool…

View details →
Negative / Null Result ReportMedicine

Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on the risk of venous thromboembolism in patients with obesity: a real-world cohort study.

Wu, Lee, Huang et al. · 2026 · Frontiers in medicine

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), represents a major cause of morbidity and mortality in patients with obesity. Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs)…

View details →
Negative / Null Result ReportMedicine

An Analysis of Thyrotropin Levels in Patients With Nonscarring Alopecia: A Single-Center Retrospective Comparative Study.

Alomary, Baker, Schell et al. · 2026 · The Journal of clinical and aesthetic dermatology

To compare thyrotropin (TSH) levels across nonscarring alopecia (NSA) subtypes-alopecia areata (AA), telogen effluvium (TE), and androgenetic alopecia (AGA)-in a primary analysis of all patients, a secondary analysis of euthyroid patients…

View details →