Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Casey W. Dunn, Felipe Zapata, Catriona Munro et al. · 2018 · Proceedings of the National Academy of Sciences
There is considerable interest in comparing functional genomic data across species. One goal of such work is to provide an integrated understanding of genome and phenotype evolution. Most comparative functional genomic studies have relied…
View details →Failed Experiment ReportEngineering
Gaëtan Ndo, Fabrice Labeau, Marthe Kassouf · 2013 · IEEE Transactions on Power Delivery
Transmission over channels impaired by impulsive noise, such as in power substations, calls for peculiar mitigation techniques at the receiver side in order to cope with signal deterioration. For these techniques to be effective, a…
View details →Replication FailureEarth and Planetary Sciences
Shunsuke Tei, Atsuko Sugimoto, Hitoshi Yonenobu et al. · 2017 · Global Change Biology
Circumboreal forest ecosystems are exposed to a larger magnitude of warming in comparison with the global average, as a result of warming-induced environmental changes. However, it is not clear how tree growth in these ecosystems responds…
View details →Negative / Null Result ReportOpen accessPsychology
Coren L. Apicella, David Cesarini, Magnus Johannesson et al. · 2010 · PLoS ONE
BACKGROUND: Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. METHODOLOGY/PRINCIPAL FINDINGS: We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n = 684). Two standard economic games, the dictator game and the trust ga
View details →Negative / Null Result ReportSocial Sciences
Amy Roberts, Jennifer LoCasale‐Crouch, Bridget K. Hamre et al. · 2016 · Early Education and Development
Research Findings: This study explored the role Head Start teachers’ (n = 355) depressive symptoms play in their interactions with children and in children’s (n = 2,203) social-emotional development, specifically changes in children’s…
View details →Negative / Null Result ReportSocial Sciences
Leigh S. Wilton, Ariana N. Bell, Mariam Vahradyan et al. · 2020 · Personality and Social Psychology Bulletin
Organizations aim to convey that they are diverse and inclusive, in part, to recruit racial minorities. We investigate a previously unexamined downside of this recruitment strategy: diversity dishonesty, that is, belief that an…
View details →Negative / Null Result ReportBusiness, Management and Accounting
Carlos Oliveira Cruz, Rui Cunha Marques · 2013 · Journal of Construction Engineering and Management
Renegotiations are frequently perceived as the Achilles’ heel of concessions. After two decades of concessions development, empirical evidence suggests a recurrent need to renegotiate contracts. What drives renegotiation? Why does it…
View details →Negative / Null Result ReportOpen accessMedicine
Marius M. Hoeper, Juergen Behr, Matthias Held et al. · 2015 · PLoS ONE
BACKGROUND: Pulmonary hypertension (PH) is a common finding in patients with chronic fibrosing idiopathic interstitial pneumonias (IIP). Little is known about the response to pulmonary vasodilator therapy in this patient population. COMPERA is an international registry that prospectively captures data from patients with various forms of PH receiving pulmonary vasodilator therapies. METHODS: We retrieved data from COMPERA to compare patient characteristics, treatment patterns, response to therapy and survival in newly diagnosed patients with idiopathic pulmonary arterial hypertension (IPAH) and
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Robert L. Ferris, Nabil F. Saba, Barbara J. Gitlitz et al. · 2018 · JAMA Oncology
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To…
View details →Negative / Null Result ReportMedicine
Bo Abrahamsen, Henrik L. Jørgensen, Anne Sofie Laulund et al. · 2014 · Journal of Bone and Mineral Research
The relationship between thyrotoxicosis and osteoporotic fractures remains controversial, particularly in men. Register-based cohort study including all patients with a serum thyrotropin (TSH) measurement in the region of Funen 1996-2010.…
View details →Negative / Null Result ReportMedicine
Yoshio N. Hall, Brett Larive, Patricia Painter et al. · 2012 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study examined changes in physical performance…
View details →Negative / Null Result ReportEngineering
Hanisom Abdullah, Kun Mediaswanti, Hongwei Wu · 2010 · Energy & Fuels
This study shows the significant differences in the fuel quality and ash properties of biochars produced from the slow pyrolysis of various biomass components (leaf, wood, and bark). The objective is to identify which component is likely…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Javier Palma‐Guerrero, Xin Ma, Stefano F. F. Torriani et al. · 2017 · Molecular Plant-Microbe Interactions
Zymoseptoria tritici is an ascomycete fungus that causes Septoria tritici blotch, a globally distributed foliar disease on wheat. Z. tritici populations are highly polymorphic and exhibit significant quantitative variation for virulence.…
View details →Negative / Null Result ReportOpen accessMedicine
Marian L. Kohut, David S. Senchina · 2026 · PubMed
Decreases in immune responsiveness with age are thought to contribute to the increased incidence and severity of infectious disease among the elderly. Several interventions, including exercise, have been proposed to restore immune function…
View details →Negative / Null Result ReportMedicine
Hyun Jin Jo, Jaeyeon Kim, Nayoung Kim et al. · 2016 · Helicobacter
BACKGROUND: Little is known about the role of gastric microbiota except for Helicobacter pylori (HP) in human health and disease. We compared the differences of human gastric microbiota according to gastric cancer or control and HP…
View details →Negative / Null Result ReportOpen accessMedicine
Michael R. Sperling, Bassel Abou‐Khalil, Jay Harvey et al. · 2014 · Epilepsia
OBJECTIVE: To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. METHODS: This randomized, placebo-controlled, double-blind, parallel-group, phase III study was…
View details →Negative / Null Result ReportOpen accessMedicine
C. Avendaño, António Ramos, Elena Múñez et al. · 2021 · Journal of Clinical Investigation
BACKGROUNDPassive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19. Evidence from controlled clinical trials is inconclusive.METHODSWe conducted a randomized, open-label, controlled clinical trial at 27…
View details →Negative / Null Result ReportMedicine
Christiane Al‐Haddad, Georges M. El Mollayess, Carol Cherfan et al. · 2011 · British Journal of Ophthalmology
BACKGROUND/AIMS: To study peripapillary retinal nerve fibre layer (RNFL) and macular thickness in amblyopia using high-definition spectral-domain optical coherence tomography (SD-OCT) and to compare the results with available literature…
View details →Negative / Null Result ReportOpen accessMedicine
J. Randolph Hecht, Sara Lonardi, Johanna C. Bendell et al. · 2021 · Journal of Clinical Oncology
PURPOSE SEQUOIA compared efficacy and safety of adding pegilodecakin (PEG), a pegylated recombinant human interleukin (IL)-10, with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) in patients following progression on first-line…
View details →Negative / Null Result ReportMedicine
Yoshinobu Onuma, Patrick W. Serruys, J.A. Fernández Gómez et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: The ABSORB cohort A trial using the bioresorbable everolimus-eluting scaffold (BVS revision 1.0, Abbott Vascular) demonstrated a slightly higher acute recoil with BVS than with metallic stents. To reinforce the mechanical…
View details →Negative / Null Result ReportMedicine
Alice Tseng, Leah Szadkowski, Sharon Walmsley et al. · 2013 · Annals of Pharmacotherapy
BACKGROUND: Interactions between antiretroviral (ARV) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population. OBJECTIVE: To investigate the association of age with potential drug-drug…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Payton J. Jones, Benjamin W. Bellet, Richard J. McNally · 2020 · Clinical Psychological Science
Trigger warnings alert trauma survivors about potentially disturbing forthcoming content. However, empirical studies on trigger warnings suggest that they are functionally inert or cause small adverse side effects. We conducted a…
View details →Negative / Null Result ReportOpen accessMedicine
Charles de Mestral · 2011 · Canadian Journal of Surgery
BACKGROUND: A multidisciplinary tracheostomy team was created in 2005 to follow critically ill patients who had undergone a tracheostomy until their discharge from hospital. Composed of a surgeon, surgical resident, respiratory therapist,…
View details →Negative / Null Result ReportMedicine
Christian von Bodman, Kazuhito Matsushita, Caroline Savage et al. · 2012 · The Journal of Urology
PURPOSE: We determined whether pelvic soft tissue and bony dimensions on endorectal magnetic resonance imaging influence the recovery of continence after radical prostatectomy, and whether adding significant magnetic resonance imaging…
View details →Negative / Null Result ReportEngineering
Michael S. Northrop, Robert F. Sidonio, Sharon Phillips et al. · 2014 · Pediatric Critical Care Medicine
OBJECTIVES: To determine if a comprehensive extracorporeal membrane oxygenation anticoagulation monitoring protocol results in fewer hemorrhagic complications, reduced blood product usage, and increased circuit life. DESIGN: In September…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jan Hanousek, Anastasiya Shamshur, Jiří Trešl · 2017 · Journal of Corporate Finance
We study the effects of corruption on firm efficiency using a unique dataset of private firms from 14 Central and Eastern European countries from 2000 to 2013. We find that an environment characterized by a high level of corruption has an adverse effect on firm efficiency. This effect is stronger for firms with a lower propensity to behave corruptly, such as foreign-controlled firms and firms managed by female CEOs, while local firms and firms with male CEOs are not disadvantaged. We also find that an environment characterized by considerable heterogeneity in the perception of corruption is as
View details →Negative / Null Result ReportOpen accessMedicine
Alex P. Di Battista, John E. Buonora, Shawn G. Rhind et al. · 2015 · Frontiers in Neurology
BACKGROUND: Blood biomarkers are valuable tools for elucidating complex cellular and molecular mechanisms underlying traumatic brain injury (TBI). Profiling distinct classes of biomarkers could aid in the identification and characterization of initial injury and secondary pathological processes. This study characterized the prognostic performance of a recently developed multi-marker panel of circulating biomarkers that reflect specific pathogenic mechanisms including neuroinflammation, oxidative damage, and neuroregeneration, in moderate-to-severe TBI patients. MATERIALS AND METHODS: Periphera
View details →Negative / Null Result Report
Cyrus Kholdani, Wassim H. Fares, Vahid Mohsenin · 2015 · Pulmonary Circulation
The development of pulmonary hypertension is a poor prognostic sign in patients with obstructive sleep apnea (OSA) and affects both mortality and quality of life. Although pulmonary hypertension in OSA is traditionally viewed as a result…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Erick H. Turner, Daniel Knoepflmacher, Lee Shapley · 2012 · PLoS Medicine
BACKGROUND: Publication bias compromises the validity of evidence-based medicine, yet a growing body of research shows that this problem is widespread. Efficacy data from drug regulatory agencies, e.g., the US Food and Drug Administration (FDA), can serve as a benchmark or control against which data in journal articles can be checked. Thus one may determine whether publication bias is present and quantify the extent to which it inflates apparent drug efficacy. METHODS AND FINDINGS: FDA Drug Approval Packages for eight second-generation antipsychotics-aripiprazole, iloperidone, olanzapine, pali
View details →Negative / Null Result ReportOpen accessMedicine
Deborah H. Ndao, Elena J. Ladas, Bin Cheng et al. · 2010 · Psycho-Oncology
OBJECTIVE: Though often lifesaving, stem cell transplantation (SCT) is a period of great distress for both child and parent. METHODS: We conducted a double-blind, placebo-controlled randomized study evaluating the effect of the respiratory…
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