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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Clinicopathology of adenocarcinoma originating from the anal gland with immunohistochemical expressions of GATA3 and TTF-1: a case report and literature review.

Shi J, Li G, Tang W et al. · 2026 · Frontiers in oncology

Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10…

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Negative / Null Result ReportMedicine

GC-MS quantification of fecal short-chain fatty acids and spectrophotometric detection of indole: Do rectal swabs produce comparable results as stool samples? - A pilot study.

K K V, P R A, Rao BK et al. · 2024 · Rapid communications in mass spectrometry : RCM

Rationale The exploration of the gut microbiome and related metabolites holds an exciting future in health science. The challenges associated with fecal sample testing are proper sample collection, sterile transportation, optimal transport…

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Negative / Null Result ReportOpen accessMedicine

Association between in-hospital antibiotic use and long-term outcomes in critically ill patients.

Burrows P, Brown RA, Samuelsen A et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Objective To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design Prospective observational study. Setting…

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Negative / Null Result ReportOpen accessMedicine

Renal safety of postoperative short-term use of flurbiprofen axetil in well-controlled hypertensive patients: a prospective multicenter cohort study.

Sun L, Jiang Y, Ma X et al. · 2026 · Frontiers in pharmacology

Background Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil…

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Methods Dead-EndOpen accessMedicine

The Clinical Validity and Utility of PCR Compared to Conventional Culture and Sensitivity Testing for the Management of Complicated Urinary Tract Infections in Adults: A Secondary (Ad Hoc) Analysis of Pathogen Detection, Resistance Profiles, and Impact on Clinical Outcomes.

Kardjadj M, Chang TW, Chavez R et al. · 2025 · Microorganisms

Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. This multicenter, randomized,…

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Failed Experiment ReportOpen accessMedicine

The effects of resistance exercise and leucine-enriched essential amino acid supplementation on muscle mass and physical function in post-gastrectomy patients: a pilot randomized controlled trial.

Sawada A, Yoneta K, Togashi E et al. · 2024 · Journal of physical therapy science

[Purpose] In gastric cancer patients, low muscle mass decreases overall survival and quality of life (QOL). Resistance exercise with leucine-enriched essential amino acid (LEAA) supplementation may prevent muscle mass loss. This study was…

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Negative / Null Result ReportOpen accessMedicine

Cross-sectional and longitudinal associations between statin use and bone density: the Manitoba BMD registry.

Leslie WD, Zarzour F, Binkley N et al. · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Statins are among the most widely prescribed medications in older individuals. Inconsistent data in humans suggest that statin medications may be associated with greater BMD and lower risk for osteoporosis. We identified 22 393 individuals…

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Negative / Null Result ReportOpen accessMedicine

Deep Learning-Based Dental Caries Diagnosis on Panoramic Radiographies: Performance of YOLOv8 Versus Human Observers.

Biçengil K, Kurt A, Naralan ME et al. · 2026 · Diagnostics (Basel, Switzerland)

Objectives : To evaluate the diagnostic performance of a YOLOv8x-based deep learning model for detecting approximal, occlusal and buccal caries on paediatric panoramic radiographs and to compare its performance with human observers with…

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Methods Dead-EndOpen accessMedicine

Whole exome sequencing and single-cell DNA sequencing for assessment of clonal heterogeneity and evolution in acute myeloid leukemia.

Adhikari S, Eldfors S, Pitkänen E et al. · 2025 · Computational and structural biotechnology journal

Background Acute myeloid leukemia (AML) progresses by the accumulation of somatic mutations and clonal expansion of pre-leukemic cells. Patients may respond to initial therapy, but often relapse, underscoring an evolving disease. Next…

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Negative / Null Result ReportOpen accessMedicine

HuR Knockdown in MLO-Y4 Osteocyte-like Cells Elevates OPG Expression and Suppresses Osteoclastogenesis In Vitro.

Fan Z, Kitaura H, Marahleh A et al. · 2025 · International journal of molecular sciences

Bone remodeling is maintained through the coordinated actions of osteoblasts, osteoclasts, and osteocytes, among which osteocytes serve as major regulators of osteoclast-mediated bone resorption through the receptor activator of the…

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Negative / Null Result ReportOpen accessMedicine

Issues with Cefiderocol Testing: Comparing Commercial Methods to Broth Microdilution in Iron-Depleted Medium-Analyses of the Performances, ATU, and Trailing Effect According to EUCAST Initial and Revised Interpretation Criteria.

Stracquadanio S, Nicolosi A, Marino A et al. · 2024 · Diagnostics (Basel, Switzerland)

Background The rise of multi-drug-resistant Gram-negative bacteria necessitates the development of new antimicrobial agents. Cefiderocol shows promising activity by exploiting bacterial iron transport systems to penetrate the outer…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of a point-of-care rapid HIV antibody test with insights into acute HIV symptomatology in a population with low prevalence.

Bui TI, Farnsworth CW, Anderson NW · 2024 · Journal of clinical microbiology

Many emergency departments (ED) use rapid human immunodeficiency virus (HIV) antibody tests as screening tools, despite limited sensitivity for detecting acute HIV infections. In a 4-year retrospective analysis of 1,192 patients, we…

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Negative / Null Result ReportOpen accessMedicine

Prognostic Impact of Different Definitions of White-Coat Hypertension.

Verdecchia P, Coiro S, Bartolini C et al. · 2025 · American journal of hypertension

Background Different definitions of white-coat hypertension (WCH) may explain its variable outcome across studies. Methods In an Italian study started in 1986, we followed 3,153 people with (office blood pressure (BP) >=140/90 mmHg) and…

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Negative / Null Result ReportMedicine

Age differences in the moderating effects of neighbourhood disadvantage on the relationship between physical activity and cognitive function: A longitudinal analysis of the Canadian Longitudinal Study on Aging.

Falck RS, Cosco TD, Wister AV et al. · 2024 · Maturitas

Objectives To explore whether the association between physical activity (PA) and cognition is moderated by neighbourhood disadvantage, and whether this relationship varies with age. Study design A longitudinal analysis of the Canadian…

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Negative / Null Result ReportMedicine

Effectiveness of eDNA for monitoring riverine macroinvertebrates.

Poyntz-Wright IP, Harrison XA, Pedersen S et al. · 2024 · The Science of the total environment

Environmental DNA (eDNA) is a technique increasingly used for monitoring organisms in the natural environment including riverine macroinvertebrates. However, the effectiveness of eDNA for monitoring riverine macroinvertebrates compared…

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