Whole exome sequencing and single-cell DNA sequencing for assessment of clonal heterogeneity and evolution in acute myeloid leukemia.
Adhikari S; Eldfors S; Pitkänen E; Vähä-Koskela M; Heckman CA · 2025 · Computational and structural biotechnology journal
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Abstract (excerpt)
Background Acute myeloid leukemia (AML) progresses by the accumulation of somatic mutations and clonal expansion of pre-leukemic cells. Patients may respond to initial therapy, but often relapse, underscoring an evolving disease. Next…
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Metadata source: Europe PMC · DOI 10.1016/j.csbj.2025.11.066