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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.

Mirzaei R, Soleimanzadeh A, Asri-Rezaei S · 2026 · Scientific reports

Dog semen conservation at cold temperatures (5 °C) is a valuable reproductive management tool, but it is bedeviled by issues of oxidative stress and mitochondrial damage that reduce sperm quality and viability. Urolithin A (UA), a natural…

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Negative / Null Result Report

Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports

Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · Preprint

Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…

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Negative / Null Result ReportMedicine

[Effects of repeated controlled ovarian stimulation on the expression of aerobic glycolysis-related enzymes at various stages of early embryo development in mice].

Shen LL, Shi BB, Xiong WY et al. · 2026 · Sheng li xue bao : [Acta physiologica Sinica]

This study aims to investigate whether the reduction in early embryonic development due to repeated controlled ovarian stimulation (COS) is associated with the expression levels of enzymes related to aerobic glycolysis. A repeated COS…

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Negative / Null Result ReportOpen accessMedicine

A Standardized Onion Peel-Derived Bioactive Ingredient Attenuates Palmitate-Induced Steatosis and Oxidative Stress by Modulating Mitochondrial Dynamics and Autophagy in HepG2 Cells.

Di Gregorio I, Migliaccio V, D'Elia M et al. · 2026 · Antioxidants (Basel, Switzerland)

Onion peel represents a valuable food by-product rich in bioactive phenolic compounds. Building on previous phytochemical investigations, an onion peel extract from the Rossa di Tropea variety was developed as a standardized bioactive…

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Negative / Null Result ReportMedicine

The effect of sesame, canola, and sesame-canola oils on oxidative stress markers in patients with type 2 diabetes: A three-way randomized crossover clinical trial.

Moghtaderi F, Zimorovat A, Raeisi-Dehkordi H et al. · 2026 · Nutrition and health

BackgroundOxidative stress plays a critical role in the pathogenesis of chronic diseases. Canola oil (CO) and sesame oil (SO), due to their antioxidant constituents, may differentially influence oxidative stress biomarkers.AimThis study…

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Negative / Null Result ReportMedicine

Depression and cognition: is there a bidirectional relationship?

Glei DA, Weinstein M · 2026 · Aging & mental health

Objectives The association between depression and cognition is well-established, but there is uncertainty regarding the direction of causation. We evaluated the relationship between depression and poor cognition in both directions. Method…

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Negative / Null Result ReportMedicine

Beyond Conventional Care: The use of Alternative Medicine by Head and Neck Cancer Patients in Pakistan - A Retrospective study.

Akhtar, Ghaloo, Pasha et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association

To investigate the prevalence, utilisation and association of diagnostic delay, tumour stage and recurrence with alternative medicine among head and neck cancer patients having undergone surgical resection. The retrospective,…

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Negative / Null Result ReportOpen accessGeriatrics

Clinical Features of CINin ChineseVery Elderly Patients Undergoing Coronary Angiography Procedure With Hydration Treatment: A Three-Center, Prospective Study

Liwen Bao, Jun Bo, Bo Jin et al. · 2018 · International Journal of Gerontology

Summary: Background: To assess the morbidity and risk factors of contrast induced nephropathy (CIN) in Chinese very elderly patients. Methods: The very elderly patients whose age ≥75 year-old, from North Huashan Hospital, South Renji Hospital and Tongren Hospital, underwent coronary angiography or percutaneous coronary intervention, were included in this study. All of these patients were treated by hydration, those who developed contrast-induced nephropathy were divided into CIN group and the others were divided into non-CIN group. The baseline information was evaluated and serum creatinine wa

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Negative / Null Result ReportOpen accessMedicine

Blue®m gel vs hyaluronic acid gel in wound healing and pain control following functional crown lengthening: a randomized controlled trial

Riddhi Vyas, Santhosh Kumar, C M Manasa · 2026 · Saudi Dental Journal

Abstract Periodontal wound dressings have advanced from passive protectants to bioactive agents. This study compared the efficacy of Blue®m gel and a hyaluronic acid (HA) gel in promoting wound healing and controlling postoperative pain after functional crown lengthening surgery. A prospective, randomized, patient and outcome assessor-blinded study was conducted on 40 systemically healthy patients (aged 20–60 years) requiring crown lengthening of posterior teeth. Participants were divided into two groups: Blue®m gel (Group A) and custom-formulated HA gel (Group B). Both gels were applied to th

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Negative / Null Result ReportOpen accessBiology (General)

Evaluation of the efficacy of N-Acetylcysteine combined with standard quadruple therapy versus standard quadruple therapy alone for Helicobacter pylori eradication

Farahnaz Joukar, Sara Manafi Afkham, Afshin Shafaghi et al. · 2023 · Journal of Current Biomedical Reports

N-acetyl cysteine (NAC) has recently been proposed as an adjunctive therapy for the eradication of Helicobacter pylori infection due to its mucolytic, antioxidant, and antimicrobial properties. This study aimed to evaluate the efficacy of adding NAC to the standard 4-drug regimen consisting of amoxicillin, clarithromycin, pantoprazole, and bismuth subcitrate. In this double-blind, randomized clinical trial, 92 patients with confirmed H. pylori infection were randomly assigned to either the intervention group or the control group (46 patients each) using a randomized block design. All patients

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Negative / Null Result ReportOpen accessMedicine

The influence of Hydroxyzine Premedication on Preoperative Hemodynamics in Pediatric Patients

gehad Abd algaliel, Amani Abo alhassein, Sarah Omar · 2024 · Minia Journal of Medical Research

BACKGROUND: Hydroxyzine is an antihistamine that belongs to the first generation of H1 Antihistamines and used in medicine for a variety of purposes. It was introduced into the field of anesthesia for a variety of reasons, including its sedative, antiemetic and anti-allergic properties. Therefore, it's critical to understand how hydroxyzine premedication affects hemodynamic changes in individuals, particularly in younger ones undergoing surgery OBJECTIVES: The objective of this study was to identify the impact of administering hydroxyzine orally before surgery on hemodynamics prior to inductio

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Negative / Null Result ReportOpen accessPhilosophy. Psychology. Religion

Methodical Approach in Catholic Religious Education in Kindergartens in Bosnia and Herzegovina

Alaksandra Šindić, Dijana Andrić, Jurka Lepičnik Vodopivec et al. · 2020 · Nova Prisutnost

In this paper, the authors explore the methodical approach in Catholic religious education in kindergartens in Bosnia and Herzegovina. The theoretical framework is represented by the concept of holistic education. It also includes spiritual education, in the case of this study, religious education. The aim of the empirical part of the research is to determine the methodical elements of religious education in preschool institutions in Bosnia and Herzegovina (types of religious educational activities in religious education of preschool children and their representation, religious climate) and to

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Negative / Null Result ReportOpen accessMedicine (General)

Anesthesia’s Influence on Postoperative In-Hospital Morbidity–Mortality in Proximal Femoral Fractures in the Elderly

Oded Hershkovich, Inga Tetroashvili, Adam Lee Goldstein et al. · 2024 · Medicina

Background and Objectives: The incidence of proximal femoral fractures (PFFs) is rising, causing significant morbidity and mortality. Regional anesthesia (RA)’s benefits include the avoidance of intubation and mechanical ventilation, decreased blood loss, and improved analgesia. General anesthesia (GA) offers improved hemodynamic stability. This study examines the in-hospital post-surgical morbidity and mortality seen in PFFs in a cohort of the elderly undergoing GA or RA. Materials and Methods: This is a retrospective cohort study of 319 PFF patients older than 65 years over a single year. Re

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Negative / Null Result ReportOpen accessDentistry

Shear Bond Strength of Universal Adhesives with Different Methods of Zirconia Ceramic Preparation after Thermocycling: A Laboratory Study

Ebrahim Yarmohammadi, Shiva Kavousinejad · 2024 · Journal of Dental School

Objectives The present study aimed to assess the level of shear bond strength (SBS) of universal adhesives (G-premio Bond Universal (GBU) and All Bond Universal (ABU) on zirconia without surface preparation, zirconia sandblasted by 50-micron aluminum oxide particles, and zirconia glazed by low-fusing ceramics after the thermocycling process. Methods Two Ceramill ZI zirconia blocks were used to prepare 18 cubes with dimensions of 10×10×10 mm. Then, based on the type of surface preparation, these 18 sintered zirconia cubes were classified into three groups of six, including the control group, sa

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Negative / Null Result ReportOpen accessSpecial aspects of education

الحالة المزاجية المميزة للتلميذات ذوات صعوبات التعلم في المرحلة الابتدائية The Temperamental Status that Distinguishes Female Students with Learning Disabilities at Elementary School

نسرين أحمد الضبيب, زيدان أحمد السرطاوي · 2016 · مجلة التربیة الخاصة والتأهیل

هدفت الدراسة الحالية إلى التعرف على الحالة المزاجية المميزة للتلميذات ذوات صعوبات التعلم في المرحلة الابتدائية، وإلى التعرف على الفروق الدالة إحصائياً في الحالة المزاجية بين التلميذات ذوات صعوبات التعلم، والتلميذات العاديات. وتکونت عينة الدراسة من )٣٠٢) تلميذة، من الصفوف الابتدائية الثلاثة العليا، بواقع )١٤٢) تلميذة من ذوات صعوبات التعلم، و(١٦٠) تلميذة عادية. واستخدم اختبار الحالة المزاجية للأطفال، لطنطاوي، وعجلان (١٩٩٥)، کأداة للدراسة. توصلت النتائج إلى أن أکثر أبعاد الحالة المزاجية لذوات صعوبات التعلم إيجابية بحسب قيم المتوسط الأعلى على التوالي هي: حدة رد الفعل، الاندفاع، مستوى النشاط، الاقت

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Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

Functional outcomes and subjective recovery of jumping to conclusions in schizophrenia

Seiichi Watanabe, Takamichi Taniguchi, Motoko Sugihara · 2021 · Schizophrenia Research: Cognition

This study investigated the effects of the bias known as jumping to conclusions (JTC) on objective functional outcomes as well as subjective assessments of quality of life (QoL) and personal recovery among a sample of patients diagnosed with schizophrenia. Specifically, this study assessed the variables of JTC, psychiatric symptoms, neurocognitive functioning, objective interpersonal and daily activities, vocational domains, subjective QoL, and personal recovery among 94 participants. Results showed that those in the JTC group had significantly lower neurocognitive and functional outcomes (mod

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Negative / Null Result ReportOpen accessMedicine

Optic Nerve Head and Retinal Nerve Fiber Layer Analysis in Ocular Hypertension and Early-Stage Glucoma Using Spectral-Domain Optical Coherence Tomography Copernicus

Nilgün Solmaz, Onur Yaya, Feyza Önder · 2014 · Türk Oftalmoloji Dergisi

Objectives: Evaluation of structural alterations of the optic nerve head (ONH) and the retinal nerve fiber layer (RNFL) in patients with ocular hypertension (OHT) and early-stage glaucoma and assessment of the discriminatory diagnostic performance of spectral-domain optical coherence tomography (SD-OCT) Copernicus (Optopol Technology S.A.). Materials and Methods: This study included 59 eyes of a total of 59 patients, 29 of whom were diagnosed with OHT (Group 1) and 30 with early-stage glaucoma (Group 2). The differentiation of early-stage glaucoma and OHT was carried out on the basis of standa

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Negative / Null Result ReportOpen accessScience (General)

Determination of cyberloafing level of speech and Language Therapy Department students

Fenise Selin Karali, Samet Tosun, Meltem Şen-Aksüt et al. · 2024 · Heliyon

Cyberloafing is the use of (e.g. smartphones, tablets, laptops, and the Internet) for purposes other than work related reasons during work hours. Although cyberloafing in the workplace has been widely investigated, there is relatively a small number of studies on cyberloafing behaviors in educational settings, which refer to students' tendencies to use technology for non-class-related purposes during lectures. The goal of the current study is to determine how frequently and for what purposes speech and language therapy (SLT) students at Biruni University engage in cyberloafing during lectures.

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Negative / Null Result ReportOpen accessGynecology and obstetrics

The effect of combined herbal capsules (Menohelp®) on early symptoms of menopause: a randomized double-blind placebo-controlled trial

Fariba Mousavi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirgafourvand et al. · 2023 · Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān

Introduction: Early symptoms of menopause are very common and often very bothersome. Considering the increasing number of women experiencing these symptoms in the world and Iran, there is a growing need to use methods to reduce these symptoms. Therefore, this study was performed with aim to determine the effect of the combined herbal capsules (Menohelp) on reducing the early symptoms of menopause, number and intensity of hot flashes (primary outcomes), and improving sleep quality and quality of life (secondary outcomes) in menopausal women. Methods: In this double-blind trial in Tabriz, 100 wo

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Negative / Null Result ReportOpen accessDentistry

In Vitro Evaluation of the Effect of Different Sandblasting Times on the Bond Strength of Feldspathic Porcelain to Composite Resin

Ebrahim Amin Salehi, Haleh Heshmat, Elham Moravej Salehi et al. · 2013 · Journal of Islamic Dental Association of Iran

Background and Aim: Intraoral repair of fractured porcelain is an acceptable method to avoid replacement and therefore saving time and cost. The purpose of this study was to determine the in-vitro shear bond strengths of composite resin to feldspathic porcelain after different durations of sandblasting and to compare the effect of sandblasting with that of hydrofluoric acid (HF ). Materials and Methods : In this in-vitro study, 40 porcelain disks were fabricated and randomly divided into 4 groups (n=10). Porcelain surface in group 1 was etched with 9.5% HF for 2 minutes. Groups 2, 3 and 4 were

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Negative / Null Result ReportOpen accessMedicine

Effect of Racking Systems Versus Enriched Terraria on Fecal Glucocorticoid Metabolites in Four Species of Captive Snakes: A Pilot Study.

Olvera-Maneu S, Regidor M, Serres-Corral P et al. · 2026 · Animals : an open access journal from MDPI

Fecal glucocorticoid metabolites (FGM) are widely used to assess hypothalamic-pituitary-adrenal (HPA) activity in vertebrates, but their applicability to reptiles, and more specifically to snakes, remains poorly explored. The objective of…

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Negative / Null Result ReportOpen accessAgriculture (General)

Technological and sensory quality of restructured low-fat cooked ham containing liquid whey Características tecnológicas e sensoriais de apresuntados com baixo teor de gordura elaborados com soro de leite

Monalisa Pereira Dutra, Giselle Pereira Cardoso, Eduardo Mendes Ramos et al. · 2012 · Ciência e Agrotecnologia

The use of liquid whey to replace water (at 0, 25, 50, 75 or 100%) in a restructured cooked ham formulation was studied and several technological and sensory quality properties were determined. The test results showed no statistically significant differences (P 0.05) less reddish (a* value reduction) and more grayish and yellowish (lesser C* and higher h values) with higher whey additions. A lower (P 0.05). These results suggest that up to 38% natural fresh liquid whey can be added to a restructured cooked ham formulation with similar results to products cured with a conventional formulation.

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Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine

Intra-fractional geometric and dose/volume metric variations of magnetic resonance imaging-guided stereotactic radiotherapy of prostate bed after radical prostatectomy

Yu Gao, Stephanie Yoon, Ting Martin Ma et al. · 2024 · Physics and Imaging in Radiation Oncology

Background and purpose: Magnetic Resonance Imaging (MRI)-guided Stereotactic body radiotherapy (SBRT) treatment to prostate bed after radical prostatectomy has garnered growing interests. The aim of this study is to evaluate intra-fractional anatomic and dose/volume metric variations for patients receiving this treatment. Materials and methods: Nineteen patients who received 30–34 Gy in 5 fractions on a 0.35T MR-Linac were included. Pre- and post-treatment MRIs were acquired for each fraction (total of 75 fractions). The Clinical Target Volume (CTV), bladder, rectum, and rectal wall were conto

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Negative / Null Result ReportOpen accessScience

Randomized Controlled Trial of Patient Positioning and Operator Radiation Exposure During Lower Extremity Catheter Angiography

Ákos Bérczi, Fanni Éva Szablics, Anita Nelli Simon et al. · 2025 · Life

Digital subtraction angiography (DSA) remains an important reference modality for evaluating chronic limb-threatening ischemia (CLTI), with left transradial access (TRA) increasingly favored for its lower complication rates and patient comfort. Radiation safety for operators is paramount, yet the impact of patient positioning on scatter radiation during lower limb diagnostic catheter angiography (CA) is understudied. This single-center randomized controlled trial evaluated whether head-first (HF) vs. feet-first (FF) supine patient orientation affects operator radiation exposure during lower ex

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