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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Neoadjuvant chemoradiation and surgical excision versus definitive radiotherapy for locally advanced cervix uteri carcinoma: in terms of early and late complications and locoregional recurrence.

Khalifa H, Ayaty M, Oreaba R et al. · 2025 · Journal of the Egyptian National Cancer Institute

Objectives Following external beam radiation therapy (EBRT) with concurrent chemotherapy, we analyzed the benefits of surgical resection for locally advanced cervical carcinoma in terms of the frequency and severity of complications and…

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Negative / Null Result ReportMedicine

[Comparison of the modified Kadish, AJCC T and Dulguerov T staging systems for olfactory neuroblastoma: analysis of the SEER database].

Lyu HH, Wen X, Lin JT et al. · 2025 · Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

Objective: To compare the Kadish T staging, AJCC T staging, and Dulguerov T staging system in terms of their impact on surgical treatment selection and survival prognosis in patients with olfactory neuroblastoma (ONB). Methods: The cases…

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Negative / Null Result ReportMedicine

Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss After COVID-19 Vaccine in Asian Population: A Preliminary Study.

Chen PY, Young TC, Lin CY et al. · 2025 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To determine the hearing outcomes in patients with sudden sensorineural hearing loss (SSNHL) after exposure to different brands of vaccines against COVID-19. Study design Cohort study. Setting Tertiary referral center. Patients…

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Negative / Null Result ReportMedicine

Effects of different positive end-expiratory pressure strategies on treating overweight patients with acute respiratory distress syndrome: A retrospective study based on large intensive care unit databases.

Zheng X, Zhang T, Zhan T et al. · 2025 · Respiratory medicine

Purpose Positive end-expiratory pressure (PEEP) refers to a vital respiratory therapeutic tool for treating ARDS. Since overweight individuals face a greater risk of pulmonary complications than others, this study aims to assess whether…

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Negative / Null Result ReportMedicine

Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of hypertriglyceridaemia-induced acute pancreatitis.

Syed-Abdul MM, Tian L, Hegele RA et al. · 2025 · The lancet. Diabetes & endocrinology

There is a well-established link between the severity of hypertriglyceridaemia and acute pancreatitis and long-term triglyceride-lowering therapies known to prevent episodes of acute pancreatitis. Therefore, it has been assumed, without…

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Negative / Null Result ReportMedicine

Endovascular management of carotid blowout syndrome.

Nas OF, Kandemirli SG, Korkmaz B et al. · 2025 · Neurological research

Objectives To evaluate success, complications and efficacy for endovascular management for carotid blowout syndrome. Methods Images were evaluated for contrast extravasation, vessel wall irregularity, pseudoaneurysm/aneurysm formation.…

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Negative / Null Result ReportMedicine

Continuous ropivacaine wound infiltration versus epidural morphine after unplanned caesarean delivery: A noninferiority randomised controlled study.

Bruillot M, Pieper A, Sourd D et al. · 2025 · European journal of anaesthesiology

Background Treatment programs designed to enhance recovery after caesarean delivery include multimodal analgesia to ensure optimal analgesia while reducing exposure to systemic opioids. Evidence for the effectiveness of continuous wound…

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Negative / Null Result ReportOpen accessMedicine

Congee Containing Carotenoids-Enriched Functional Ingredient from Tomato Improves Cognition, Serum α-Synuclein, Monoaminergic Function, and Gut-Brain Axis Functions in the Elderly Volunteers.

Wattanathorn J, Muchimapura S, Thukham-Mee W et al. · 2025 · Life (Basel, Switzerland)

Owing to the need for a brain supplement targeting neuroprotection against age-related brain disorders and the known effect of carotenoids on brain function, we aimed to assess the effect of consuming carotenoid-rich functional congee for…

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Negative / Null Result ReportMedicine

Inadequate consumption of dietary fatty acids is a risk factor for ovarian cancer: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.

Lao J, Wei Y, Liu F et al. · 2025 · European journal of nutrition

Purpose Currently, there is controversy surrounding the association between dietary fatty acids (FAs) and ovarian cancer (OC) risk. We aimed to elucidate the aforementioned topic using data from a large cohort. Methods Women participating…

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Negative / Null Result ReportMedicine

The Effect of External Distractions on Simulated Laparoscopic Performance.

Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the risk of atrial fibrillation in patients with chronic recurrent pericarditis prescribed colchicine: Observations using TriNetX global federated research network.

Kaşkal M, Bucci T, Alobaida M et al. · 2025 · European journal of clinical pharmacology

BACKGROUND: Chronic pericarditis is associated with significant cardiovascular morbidity, including atrial fibrillation (AF), heart failure (HF), and stroke. Colchicine is widely used in pericarditis management for its anti-inflammatory…

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Negative / Null Result ReportOpen accessMedicine

Surveillance after treatment for head and neck cancer.

Koivunen P · 2026 · Current opinion in otolaryngology & head and neck surgery

Purpose of review Systematic follow-up protocols, often including regular imaging, are an essential component of posttreatment care for head and neck cancer, aimed at the early detection of disease relapse and mitigating treatment-related…

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Negative / Null Result ReportOpen accessMedicine

Hyperthermic intraperitoneal chemotherapy plus SOX chemotherapy versus SOX chemotherapy alone in patients with gastric cancer and peritoneal metastasis: a phase II randomized clinical trial.

Luo L, Zhang Z, Zeng H et al. · 2025 · Journal of gastrointestinal oncology

Background The prognosis of patients with gastric cancer with peritoneal metastasis (GCPM) is exceedingly poor. This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel combined with…

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Failed Experiment ReportMedicine

Translating Pharmacokinetic-Pharmacodynamic Principles Into Improved Methodology for Clinical Trials That Compare Intermittent With Prolonged Infusion of Beta-Lactam Antibiotics.

Tilanus AM, Shields RK, Lodise TP et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…

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Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

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Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

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