Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Jenny Brouwer, Radboud J. E. M. Dolhain, Johanna M. W. Hazes et al. · 2019 · ACR Open Rheumatology
Objective Subfertility, a time to pregnancy (TTP) longer than 12 months, is present in 40% of female patients with rheumatoid arthritis (RA) who are actively trying to conceive. Because patients with RA appear to reach menopause at a younger age, diminished ovarian function may explain the reduced fertility. Serum anti‐Müllerian hormone (AMH) levels are the best proxy to measure ovarian function. Our objectives were to study AMH levels in female patients with RA and determine the association of preconception serum AMH levels with TTP. Methods A post hoc analysis was performed before conception
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Novo-Rodríguez, Beatriz García-Fontana, Juan De Dios Luna-Del Castillo et al. · 2018 · PLoS ONE
Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently been linked to vascular biology. The current study aimed to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardiovascular mortality in individuals with and without type 2 diabetes. We followed up a cohort of 130 participants (mean age 56.8 years; 48.5% fem
View details →Negative / Null Result ReportOpen accessNursing
Stefanus Mendes Kiik, Muhammad Saleh Nuwa · 2021 · Jurnal Keperawatan Indonesia
Children with stunting in Indonesia and other low-middle countries remains a serious problem. This study aimed to identify the association between maternal education, maternal age, maternal height, preceding birth interval, and ANC clinic visits and stunting among vulnerable children in Kupang Regency, Indonesia. A cross-sectional study was conducted of two villages in Kupang Regency. The study sample comprised female ex-refugees from Timor Leste who had children aged 24–59 months. The subjects were chosen using consecutive sampling, with a total number of 154. Data were collected from both pr
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Ximena Baez-Navarro, Nadine S. van den Ende, Anh H. Nguyen et al. · 2024 · Breast Cancer Research
Abstract Most patients with triple-negative breast cancer (TNBC) are not candidates for targeted therapy, leaving chemotherapy as the primary treatment option. Recently, immunotherapy has demonstrated promising results in TNBC, due to its immunogenicity. In addition, a novel antibody–drug conjugate, namely, trastuzumab-deruxtecan, has shown effectiveness in TNBC patients with low-HER2 expression (HER2-low). These novel treatment options raise the question about the potential association between the density of stromal tumor-infiltrating lymphocytes (sTILs) and the level of HER2 expression. We a
View details →Negative / Null Result ReportOpen accessMathematics
I. Jug, D. Jug, M. Sabo et al. · 2011 · Turkish Journal of Agriculture and Forestry Sciences
Eight different soil tillage systems (TS) for winter wheat after soybean crop production were compared at the chernozem soil type in Croatian Baranya region in a 4-year period (2001/2002, 2002/2003, 2003/2004, 2004/2005). Tillage systems…
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Yongchao Zhang, Shanshan Chen, Hualei Chen et al. · 2023 · Cancer Medicine
Abstract Background The association between Glasgow Prognostic Score (GPS) and the modified Glasgow Prognostic Score (mGPS) and clinical outcomes in patients receiving immune checkpoint inhibitors (ICIs) remains controversial. Thus, this meta‐analysis aimed to examine the prognostic performance of GPS and mGPS in patients treated with ICIs. Methods Eligible studies were retrieved from searches of EMBASE, PubMed, Web of Science, and Cochrane Library until July 2021. The hazard ratio (HR) and 95% confidence intervals (CIs) were pooled by using fixed‐effect or random‐effects model to evaluate the
View details →Negative / Null Result ReportOpen accessOphthalmology
Pear Pongsachareonnont, Nopphawan Uramphorn, Nuchanad Hounnaklang · 2018 · International Journal of Ophthalmology
AIM: To evaluate the association between visual impairment (VI) and mental health or social engagement in older adults living in rural Thailand. METHODS: Data for this cross-sectional study were drawn from a community survey conducted in 2015 in Saraburi Province, Thailand. Participants were 327 adults aged ≥50y. VI was assessed using presenting distance visual acuity. Mental health and social engagement were evaluated in face-to-face interviews using validated questionnaires. After determining the prevalence of VI and relevant sociodemographic characteristics, multivariate regression analysis
View details →Negative / Null Result ReportOpen accessMedicine
Megumi Yokota, Akira Hirasawa, Kazuya Makita et al. · 2015 · Menopause Review
Introduction : Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related gene
View details →Negative / Null Result ReportOpen accessMedicine
Mehmet Yortanlı, Ramazan Köylü, Öznur Köylü et al. · 2025 · Eurasian Journal of Emergency Medicine
Aim: This study aimed to evaluate the diagnostic and prognostic significance of serum beta-trace protein (BTP) levels in patients diagnosed with sepsis in the emergency department. Materials and Methods: This prospective, single-center, observational clinical study was conducted in the emergency department and intensive care unit of a tertiary hospital. A total of 104 sepsis patients and 48 healthy adult volunteers who presented to the emergency department between April 2015 and October 2015 were included. Blood samples were collected on days 1 and 3, and BTP levels were measured using the ELI
View details →Negative / Null Result ReportOpen accessMedicine
Aditi Prayag, Salima Bijapuri, Shweta Bhatbolan et al. · 2025 · Journal of Clinical and Diagnostic Research
Introduction: Breastmilk is recognised as the best infant nutrition, but Exclusive Breastfeeding (EBF) rates remain as low as 63.7% in India and 48% worldwide. One barrier is the development of Musculoskeletal Disorders (MSDs) in postpartum mothers due to a lack of education on proper breastfeeding posture. These factors can impact the quality of the infant’s latch, resulting in early cessation of breastfeeding. Aim: This study aimed to assess the impact of ergonomic breastfeeding on the risk of developing MSD in lactating mothers and infant latch quality. Materials and Methods: The present qu
View details →Negative / Null Result ReportOpen accessMedicine
Yaser Mokhayeri, Seyed Saeed Hashemi-Nazari, Mohammad Ali Mansournia et al. · 2017 · Epidemiology and Health
OBJECTIVES Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed to evaluate the associations of PA types (total, moderate/vigorous, and intentional), as well as walking pace, with AF risk in men and women. METHODS Using the Multi-Ethnic Study of Atherosclerosis Typical Week Physical Activity Survey, 3 PA measures and walking pace were calculated among 6,487 men a
View details →Negative / Null Result ReportOpen access
Agus Arijanto · 2022 · Cognizance Journal of Multidisciplinary Studies
This study aims to analyze the effect of transformational leadership style and work motivation on employee organizational citizenship behavior (OCB) mediated by employee job satisfaction. The object of the research is employees of PT.…
View details →Negative / Null Result ReportOpen accessMedicine
Jihye Kim, Carol J. Boushey, Lynne R. Wilkens et al. · 2022 · BMC Medicine
Abstract Background Plant-based diets assessed by a priori indices are associated with health outcomes. This study investigated the associations between pre-defined indices of plant-based diets and risk of colorectal cancer (CRC) and evaluated whether the association varies by sex, race and ethnicity, and anatomic subsite of tumors. Methods A total of 79,952 men and 93,475 women who participated in the Multiethnic Cohort Study were included. Primary outcome was incidence of invasive CRC. Cox models were used to estimate the risk of CRC across quintiles of three plant-based diet scores: overall
View details →Negative / Null Result ReportOpen accessMedicine
Fumi Irie, Ryu Matsuo, Satomi Mezuki et al. · 2024 · Scientific Reports
Abstract Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. The 1148 study patients were categorized into current and noncurrent smokers. The association between smoking and clinical outcomes, incl
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Nuria Valdés, Nuria Valdés, Ana Romero et al. · 2024 · Frontiers in Endocrinology
IntroductionHistorically, Multiple Endocrine Neoplasia type 1 (MEN1)-related pituitary adenomas (PAs) were considered more aggressive and treatment-resistant than sporadic PAs. However, recent studies suggest similarities in their behavior. This study aimed to evaluate the long-term outcomes of MEN1 PAs and identify predictive factors.MethodsNationwide multicenter retrospective cohort study of MEN1-related PAs with a minimum 1-year follow-up, collecting patient demographics, germline MEN1 pathogenic variants (PV), PA size, secretory profile, radiological characteristics, treatments, and outcom
View details →Negative / Null Result ReportOpen accessMedicine
Eman A Al Abdulsalam, Mohamed S Al-Hajjaj, Mohammad S Alanazi et al. · 2020 · Journal of Nature and Science of Medicine
Objectives: Several genes, including interleukin-13 (IL13), MS4A2, and IL 4 receptor alpha (IL4Rα), have been shown to associate with the inflammatory process in asthma. We investigated the possible association between asthma and five single-nucleotide polymorphisms (SNPs) in the IL13, IL4Rα, and MS4A2 gene in comparison with the level of the IL-13 protein in the Saudi asthmatics and controls. Subjects and Methods: The study group included 50 adult asthmatic patients and 50 normal healthy controls. Blood was extracted, and DNA was prepared. Genotyping was performed on DNA using direct sequenci
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Barrak Alahmad, Taofik Oyekunle, Claire Strohmeyer et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Arrhythmia, particularly atrial fibrillation, is on the rise globally. While increased surveillance, aging populations, and other risk factors partially explain this rise, emerging risks such as extreme heat from climate change are underexplored. Methods We used Product Surveillance Registry by Medtronic (2016–2023) in the United States to examine patients with implantable cardioverter‐defibrillator or cardiac resynchronization therapy defibrillator devices. We identified first arrhythmic episodes (atrial tachycardia/fibrillation [AT/AF] or ventricular tachycardia/fibrillation) reco
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Kollipara Sumanth, Uma Sinharoy, Anindita Joardar et al. · 2026 · Annals of Indian Academy of Neurology
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
View details →Short NoteMedicine
Fahrenhorst-Jones T, Pereira R, Craigie M · 2026 · BMJ case reports
A woman aged in her 50s presented with sudden onset of vertigo, headaches and epistaxis, initially attributed to her background of chronic systemic hypertension. Ophthalmological history was significant for bilateral proliferative diabetic…
View details →Negative / Null Result ReportOpen accessDiseases of the respiratory system
Suzanne L. Pollard, John J. Lima, Karina Romero et al. · 2017 · Asthma Research and Practice
Abstract Background Prior evidence suggests that vitamin D deficiency may increase the risk of asthma and atopy and impair pulmonary function in children. Methods In this cross-sectional analysis nested in a case-control study, we analyzed serum 25(OH)D concentrations in 413 children with asthma and 471 children without asthma living in two geographically adjacent study communities (Pampas and Villa El Salvador). We measured total and antigen-specific IgE levels, pulmonary function, asthma control, and exhaled nitric oxide. Results Mean 25(OH)D concentrations were 25.2 ng/mL (SD 10.1) in child
View details →Negative / Null Result ReportOpen accessGynecology and obstetrics
Ruiqi Wang, Yaqi Lin, Lixue Chen et al. · 2025 · Journal of Ovarian Research
Abstract Objective This multicenter retrospective study examines the impact of female COVID-19 infection on assisted reproductive technology (ART) outcomes, including clinical pregnancy rates, miscarriage rates, and live birth rates, and further evaluated potential influencing factors associated with these outcomes. Methods Our multicenter retrospective cohort study analyzed 10,140 cycles (2021–2023) from 10 Beijing ART centers, comparing 4,099 cycles from COVID-19-positive women with 6,041 age-matched (1:1.5) COVID-negative controls (pre-pandemic). Outcomes included pregnancy, miscarriage, an
View details →Negative / Null Result ReportOpen accessMedicine
Lauren S. Keenan-Devlin, Ann E. B. Borders, Alexa Freedman et al. · 2023 · Scientific Reports
Abstract Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM), also may influence the course of pregnancy and risk of adverse birth outcomes. We aimed to estimate associations between maternal CM exposure and small-for-gestational-age birth (SGA) and preterm birth (PTB) in a diverse US sample, and to examine whether common CM-associated health and behavioral sequelae either moderate or mediate these associations. The Measurement of Maternal
View details →Negative / Null Result ReportOpen accessMedicine
Amir Mari, Wasef Na’amnih, Loay Ghantous et al. · 2023 · Scientific Reports
Abstract Gastro-esophageal reflux disease (GERD) can cause erosive esophagitis (EE) and compromise the quality of life (QoL). We examined differences in symptom severity and QoL according to EE severity grade. A follow-up study was conducted among GERD patients at the Nazareth Hospital in Israel. Patients underwent a baseline gastroscopy in 2014–2020 during which the EE grade was determined using the Los Angeles classification. Follow-up telephone interviews were conducted during 2019–2020 with a mean time interval of 18.9 months (SD = 14.9) after the baseline gastroscopy to assess GERD sympto
View details →Replication FailureOpen accessNutrition. Foods and food supply
Ziqi Sang, Ziqi Sang, Han Wang et al. · 2025 · Frontiers in Nutrition
BackgroundHepatic fibrosis and the fatty liver index (FLI) are critical indicators for assessing the progression and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) and serve as valuable reference markers for predicting MASLD-related risks. The Dietary Inflammation Index (DII) quantifies the inflammatory effects of dietary intake and has been extensively utilized in nutritional and epidemiological studies. Although studies have been conducted to confirm the correlation between dietary quality and MASLD in the general population, this study sought to further explore
View details →Replication FailureOpen accessInfectious and parasitic diseases
Edlin Brian R, Yeager Meredith, Xiao Nianqing et al. · 2008 · BMC Infectious Diseases
Abstract Background Genetic variations in MBL2 that reduce circulating levels and alter functional properties of the mannose binding lectin (MBL) have been associated with many autoimmune and infectious diseases. We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection. Methods Participants were enrolled in the Urban Health Study of San Francisco Bay area injection drug users (IDU) during 1998 through 2000. Study subjects who had a positive test for HCV antibody were eligible for the current study. Participants who were positive for HCV RNA were frequency ma
View details →Abandoned HypothesisOpen accessMedicine
A. Saiiari, M. Kashef, M. Adel et al. · 2017
Background: In the majority of cardiovascular diseases, cardiovascular structure changes in line with the type of disease. One of the goals of cardiac rehabilitation is the improvement of cardiac performance and reversibility of…
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Christian Borel, Caroline Even, Christophe Le Tourneau et al. · 2023 · BMJ Oncology
Objective Salivary gland cancers (SGC) are rare cancers with currently no standard treatment for recurrent/metastatic disease. Based on checkpoint inhibitors benefit in a broad range of tumours, NIvolumab in Salivary gland CArcinoma of the Head and Neck (NISCAHN) evaluated nivolumab efficacy in SGC.Methods and analysis In this phase II single-stage Fleming design, patients with SGC with a progressive disease progression within 6 months prior to entering the study, were divided into ACC (adenoid cytic carcinoma) and non-ACC. All received nivolumab for a maximum of 12 months. The primary endpoin
View details →Negative / Null Result ReportOpen accessMicrobiology
José C. Segovia, Juan C. Ramírez, Paula Río et al. · 2025 · Microbiology Spectrum
ABSTRACT Two strains of the minute virus of mice (MVM) parvovirus (of the species Protoparvovirus rodent1), named i (immunosuppressive) and p (prototype), show disparate tropism and pathogenicity in mice. Unlike the virulent MVMi, the MVMp is attenuated and infection-restricted in primary mouse hematopoietic cells; however, it does infect human transformed, established, and stem cells. We thus seek here a putative MVMp natural tropism to humans compared to MVMi. Infectious purified MVMp virions suppress in vitro the clonogenic potential of human committed (erythroid and myeloid) and primitive
View details →Negative / Null Result ReportOpen accessMedicine
Lei Huang, Tong Li, Lei Xu et al. · 2016 · Chinese Medical Journal
Background: There has been no external validation of survival prediction models for severe adult respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO) therapy in China. The aim of study was to compare the performance of multiple models recently developed for patients with ARDS undergoing ECMO based on Chinese single-center data. Methods: A retrospective case study was performed, including twenty-three severe ARDS patients who received ECMO from January 2009 to July 2015. The PRESERVE (Predicting death for severe ARDS on VV-ECMO), ECMOnet, Respiratory Extracorpore
View details →Methods Dead-EndOpen accessMedicine (General)
Xiaohui Yang, Yue Meng, Huiyan Feng et al. · 2025 · Frontiers in Medicine
BackgroundEndometriosis is a chronic gynecological condition that can result in pelvic pain and infertility, thereby significantly impacting women's reproductive health. Psychological disorders such as anxiety and depression are common in women with endometriosis and can have a detrimental effect on their quality of life. Conventional postoperative care primarily focuses on medical and surgical aspects; however, there is a growing need to address the psychological wellbeing of patients as part of comprehensive postoperative care. Music listening interventions have emerged as a promising adjunc
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