Negative / Null Result ReportOpen accessSurgery
Qing-Quan Chen, Qing-Quan Chen, Han-Lin Chen et al. · 2025 · Frontiers in Surgery
BackgroundThe incidence of secondary displacement in fractures of the greater tuberosity of the humerus remains high, irrespective of whether conservative or surgical treatment is administered. However, the specific risk factors contributing to secondary displacement of the greater tuberosity of the humerus have not been previously reported. The primary objective of this study was to analyze the risk factors associated with secondary displacement of the greater tuberosity of the humerus and to summarize corresponding guidelines for clinical diagnosis and treatment.MethodsA retrospective analys
View details →Negative / Null Result ReportOpen accessMedicine
LI Yongxu, LIN Libin, LU Taotao et al. · 2023 · 康复学报
ObjectiveTo observe the effect of swimming exercise preconditioning on neurological function and expression levels of brain derived neurotrophic factor (BDNF), serine-threonine kinase (Akt) and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) proteins in perihematoma tissues of mice with intracerebral hemorrhage (ICH).MethodsA total of 60 male C57BL/6 mice were randomly divided into sham group, ICH 7 d group, SEP+ICH 7 d group (preconditioning group 1), ICH 14 d group and SEP+ICH 14 d group (preconditioning group 2), with 12 cases in each group. The preconditioning group 1
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Daniele Faria Miguel, Maria Teresa Terreri, Rosa Maria Rodrigues Pereira et al. · 2020 · Advances in Rheumatology
Abstract Background Urinary parameters, anti-dsDNA antibodies and complement tests were explored in patients with childhood-Systemic Lupus Erythematosus (cSLE) early-onset lupus nephritis (ELN) from a large multicenter cohort study. Methods Clinical and laboratory features of cSLE cases with kidney involvement at presentation, were reviewed. Disease activity parameters including SLEDAI-2 K scores and major organ involvement at onset and follow up, with accrued damage scored by SLICC-DI, during last follow up, were compared with those without kidney involvement. Autoantibodies, renal function a
View details →Negative / Null Result ReportOpen accessDentistry
Ravi Bhujbal, Neelima A Malik, Nilesh Kumar et al. · 2018 · Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Surgical removal of mandibular third molars results in pain, swelling and bony defects, causing prolonged postoperative recovery. The growth factors present in platelet-rich plasma (PRP) can accelerate the healing, thereby shortening postoperative recovery period. This study was undertaken to evaluate the role of PRP in postoperative socket healing, pain, swelling and bone regeneration following surgical removal of impacted mandibular third molars. Methods. The present case‒control study was conducted on 20 patients with identical bilateral mandibular third molar impaction. PRP was
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Buket Akcan, Asim Örem, Yahya Altinkaynak et al. · 2022 · Frontiers in Nutrition
Background and ObjectiveDue to the frequency of meal ingestion, individuals spend the majority of the day, ~18 h, in a status of post-prandial (PP) stress. Remnant-like lipoprotein particles (RLPs) are predominant in PP phase playing an important role in the development of atherosclerosis. Endothelial progenitor cells (EPCs) have been suggested to play a role in vessel wall homeostasis and in reducing atherosclerosis. However, there is no information about peripheral blood EPCs number following PP stress. We investigated the association between circulating EPCs levels and extent of PP lipemia
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Virginia Rega, Stefanie Brause, Sabine BR Kästner et al. · 2025 · Journal of Feline Medicine and Surgery
Objectives The objective of this study was to compare the use of the feline Glasgow Composite Measured Pain Scale (CMPS-f) at home and in a veterinary hospital. The hypothesis was that pain-free cats would score higher in the CMPS-f when in a stressful situation than when calm and relaxed; that is, healthy but stressed cats could appear to be in discomfort or pain. Methods Healthy, non-painful adult cats owned by clinical staff were included in a prospective clinical trial with two observers (caregiver [CG] and researcher). Cats were scored by their CG at home (H), after arrival at the clinic
View details →Negative / Null Result Report
Fang P · 2026 · Preprint
Abstract Objective. To track and characterize the trajectory of an individual's physical and mental health using an exploratory single-case design. Methods. Grounded in self-study methodology, this study adopted a single-case, longitudinal…
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
O. A. Saygina, T. S. Sukhinina, M. A. Terenicheva et al. · 2026 · Рациональная фармакотерапия в кардиологии
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute heart failure, hypotension, bradycardia, disorders of atrioventricular conduction (AV conduction), etc.) compared with the control group.Material and methods. The presented study is part of the randomized controlled trial ESMO-VASCMI (ClinicalTrials.gov NCT number 06376630) on the study of the cardioprot
View details →Negative / Null Result ReportOpen accessMedicine
Shurong Huang, Zhe Su, Huiping Su et al. · 2022 · Scientific Reports
Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of puberty (EOP). This case–control study enrolled 254 girls with EOP from the Endocrinology Department at Shenzhen Children’s Hospital between December 2018 and August 2019. Ultra-performance liquid chromatography and tandem mass spectrometry were used to analyze the 10 metabolites of PAEs (mPAEs) in urine samples. BA was measured using an artificial intelligen
View details →Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Edvan de Queiroz Crusoe, Fabiana Higashi, Maria Paula Nalesso Camargo Padilha et al. · 2014 · Revista Brasileira de Hematologia e Hemoterapia
Background: Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma. Objective: The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and dexamethasone, and whether cyclophosphamide, thalidomide, and dexamethasone were associated with better results than thalidomide and dexamethasone. Methods: The records of 152 patients who underwent autologous transplantation at this institution
View details →Negative / Null Result ReportOpen accessSpecial aspects of education
Élida de Fátima Diniz Souza, Ana Paula Ramos Machado, José Danúzio Leite de Oliveira et al. · 2025 · BMC Medical Education
Abstract Background In Brazil, residency programmes in Family and Community Medicine (FCM) and Multiprofessional Residency in Family Health (MRFH) are two-year specialisation courses, funded by the federal government, which aim to train professionals to work in Primary Health Care (PHC). The aim of this study was to draw up an inventory of the assessed competences of the residency programmes in the state of Paraíba, Brazil. Our study’s hypothesis is that self-assessment of competences can be a useful tool for monitoring the development of competences in the training of health professionals, co
View details →Negative / Null Result ReportOpen accessMedicine
Christine B. French, Sharon L. McDonnell, Reinhold Vieth · 2019 · Journal of Medical Case Reports
Abstract Background Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation is affected by the pre-dose versus post-dose timing of the blood draw. Case presentation The participant in this case study was a generally healthy Caucasian woman in her 40s who has taken 5000 IU vitamin D3 supplement at midday for over 1 year. Each blood sample was drawn individually from
View details →Negative / Null Result ReportOpen accessSpecial aspects of education
Wei Han Hong, Jamunarani Vadivelu, Esther Gnanamalar Sarojini Daniel et al. · 2015 · Medical Education Online
Background: Studies have shown the importance of metacognition in medical education. Metacognitive skills consist of two dimensions: knowledge of metacognition and regulation of metacognition. Aim: This study hypothesizes that the knowledge and regulation of metacognition is significantly different at the beginning and end of the academic year, and a correlation exists between the two dimensions of metacognitive skills with academic performance. Methods: The Metacognitive Skills Inventory comprising 52 Likert-scale items was administered to 159 first-year medical students at the University of
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Steven M. Hadley BA, John J. Peabody MD, Sarah Westvold MPH et al. · 2024 · Foot & Ankle Orthopaedics
Category: Ankle; Trauma Introduction/Purpose: It remains unclear whether ankle fracture pattern as described by the Weber classification—a reproducible method describing the level of fracture with respect to the distal tibiofibular syndesmosis—impacts outcomes. Patient Reported Outcome Measurement Information System (PROMIS) is a validated measure of outcomes after foot and ankle surgery. To our knowledge, no study has compared PROMIS scores between Weber subtypes. Our study thus examines whether Weber fracture subtype impacts surgical outcomes as measured by PROMIS scores. We hypothesize that
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Zeynab Arbabi, Abdolali Banaiefar, Sajjad Arshadi et al. · 2023 · پیاورد سلامت
Background and Aim: Metabolic syndrome refers to a set of metabolic disorders related to obesity, such as abdominal obesity, increased body fat mass, lipid disorders, hypertension, increased blood glucose, and insulin resistance. The present study was conducted with the aim of determining the effect of 8 weeks of CXWORX exercises combined with inulin consumption on some indicators of oxidative stress in obese women with metabolic syndrome. Materials and Methods: Forty eight obese women with metabolic syndrome in the age range of 30 to 40 years were randomly divided into Control, inulin, CX exe
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Ibrahim Halil YASAK, Mustafa YILMAZ, Murat GÖNEN et al. · 2020 · Arquivos de Neuro-Psiquiatria
ABSTRACT Objective: Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) enzyme levels were investigated in patients with epilepsy, epileptic seizure, remission period, and healthy individuals. Methods: Three main groups were evaluated, including epileptic seizure, patients with epilepsy in the non-seizure period, and healthy volunteers. The patients having a seizure in the Emergency department or brought by a postictal confusion were included in the epileptic attack group. The patients having a seizure attack or presenting to the Neurology outpatient department for follow up were included in the non-se
View details →Negative / Null Result ReportOpen accessFermentation industries. Beverages. Alcohol
Antika Boondaeng, Sumaporn Kasemsumran, Kraireuk Ngowsuwan et al. · 2022 · Fermentation
Pineapples are a tropical fruit with high nutritional value and high vitamin and sugar contents. In this study, low-grade pineapples were fermented to produce vinegar using surface culture fermentation (SCF), which involved the addition of dragon fruit juice, to compare the quality and antioxidant activity of different preparations of vinegar. The highest acetic acid concentration (7.35%) was obtained from pineapple vinegar after 20 days of incubation. Vinegar made from mixed pineapple and dragon fruit juice without peel and vinegar with pineapple and dragon fruit juice with peel had acetic ac
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Xiaohang Chen, Xin Zhou, Yan Xu et al. · 2024 · Frontiers in Public Health
BackgroundThe current rate of organ donation in China falls significantly below the global average and the actual demand. Nursing students play a crucial role in supporting and promoting social and public welfare activities. This study primary aims to analyze the levels of knowledge, attitudes, willingness toward organ donation, and attitudes toward death among nursing students, and investigate the mediating role of attitude in the relationship between knowledge and willingness. The secondary aims to identify factors that may influence the willingness.MethodsA convenience sample of nursing stu
View details →Negative / Null Result ReportOpen accessMedicine
ZHANG Yanan, MAO Chuanwu, XIONG Chenglong et al. · 2022 · Shanghai yufang yixue
ObjectiveTo explore the effects of different dietary induction models of inulin， resistant starch RS3 and their complexes on the body weight and intestinal flora in mice.MethodsA total of 64 C57BL/6 mice were randomly divided into low-fat control group， low-fat inulin group， low-fat resistant starch RS3 group， low-fat composite group and high-fat control group， high-fat inulin group， high-fat resistant starch RS3 group and high-fat composite group for dietary intervention. The mice were weighed and fresh feces were collected weekly. Diet intervention was continued until the weight of the high-
View details →Negative / Null Result ReportMedicine
Vermot-Desroches V, Rezkallah A, Kodjikian L et al. · 2026 · Journal francais d'ophtalmologie
Purpose The goal of the present study was to compare the effect of nasal versus temporal placement of the iStent Inject W® during phacoemulsification on intraocular pressure (IOP). Design and participants Over 5 consecutive years, 389 eyes…
View details →Negative / Null Result ReportOpen accessMedicine (General)
F Ansari, L Akbari, SH Kohan · 2021 · Armaghane Danesh Bimonthly Journal
Background & aim: Background and Aim: Among working women, health professionals are more exposed to environmental factors and unfavorable working conditions than working women. A large group of health professionals consists of nurses and operating room staff who provide services in hospitals. For this purpose, the present study was conducted to determine the effect of unfavorable working conditions on the incidence of spontaneous abortion in operating room staff and nurses of teaching hospitals in Isfahan. Methods: This was a retrospective analytical study. The statistical population included
View details →Negative / Null Result ReportOpen accessSurgery
Nguyen Tai Thu, Pham Dang Hai, Nguyen Thi Kieu Ly et al. · 2024 · Egyptian Liver Journal
Abstract Background Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective: This study aims to evaluate left ventricular systolic function in cirrhotic patients undergoing liver transplantation using speckle-tracking echocardiography. Methods A prospective observational study was conducted involving 54 cirrhotic patients who underwent liver transplantation, along with 28
View details →Negative / Null Result ReportOpen accessPediatrics
Mohaddeseh Badpeyma, Roghayeh Molani-Gol, Fatemeh Sistanian et al. · 2024 · Iranian Journal of Neonatology
Background: This study aims to determine the effect of different GnRH agonist brands on body mass index (BMI), weight, and height in patients referred to the pediatric endocrinology clinic of Akbar Hospital.Methods: In this cohort study, 80 girls aged 5-8 years diagnosed with precocious puberty cases were included according to the Tanner staging and at the second puberty stage. The patients were classified into three groups of GnRH agonists, A, B, and C, receiving Diphereline, Microrelin, and Variopeptyl, respectively. Height, weight, and BMI were calculated every three months.Results: In grou
View details →Negative / Null Result ReportOpen accessDentistry
Sara Jafarimofrad, Hamid Sarlak, Shima Nourmohammadi · 2022 · Dental Research Journal
Background: Control of pain, fear, and anxiety of pediatric dental patients is a common concern for the parents and dental clinicians. This study aimed to compare the efficacy of audiovisual distraction (AVD) and mute-video distraction (MVD) for reduction of pain and anxiety of pediatric dental patients. Materials and Methods: This randomized split-mouth crossover clinical trial evaluated 60 systemically healthy children between 4 and 7 years requiring bilateral pulpotomy of primary maxillary first molars. The samples were randomly divided into 6 groups based on the distraction technique and s
View details →Negative / Null Result ReportOpen accessMedicine (General)
Osama Ragaa Abdelraouf, Amr Almaz Abdel-aziem · 2021 · Chinese Journal of Traumatology
Purpose: This study evaluated the angular kinematic and moment of the ankle and foot during shod walking and barefoot walking in individuals with unilateral chronic ankle instability (CAI). Methods: Recreational soccer players with unilateral CAI were recruited for this cross sectional study conducted between January and August 2019. A total of 40 participants were screened for eligibility but only 31 met the inclusion criteria based on the methods of Delahunt et al and Gribble et al. Except for 3 participants not attending the evaluation session, 28 participants were finally included. A three
View details →Negative / Null Result ReportOpen accessMedicine
Sabah Jalal Sherif, Baderkhan Saeed Ahmed, Botan Abdul Kadir Ali · 2023 · Advanced Medical Journal
Background and objective: Acute appendicitis is one of the most common surgical emergency con-ditions. This study was done to clarify the effect of antibiotics in reducing post appendectomy com- plications after open and laparoscopic appendectomy in patients with non-perforated appendicitis. Methods:This is a randomized controlled trial. Three hundred and twenty one patients, who underwent appendectomy for non-perforated appendicitis and fulfilled the selection criteria, were randomly divided into two groups. The patients in group A received double dose of pre-operative and postoperative antib
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Guozhong Wang, Quanming Zhao, Qing Cheng et al. · 2019 · BMC Cardiovascular Disorders
Abstract Background The rational length of stay following non-complicated percutaneous coronary intervention (PCI) for Non-ST elevation myocardial infarction (NSTEMI) patients remains controversial. Few studies have examined the impact of early discharge on short-term outcomes in NSTEMI patients, but short-time discharge is not uncommon in real world practice. This study examined the impact of short time discharge following non-complicated PCI on 30-day net adverse clinical events in NSTEMI patients. Methods This retrospective study enrolled 1424 consecutive patients with NSTEMI diagnoses who
View details →Negative / Null Result ReportOpen accessPlant culture
Qing Zhou, Qing Zhou, Qing Zhou et al. · 2020 · Frontiers in Plant Science
Triploid breeding is a central way to improve growth traits, timber quality, and stress resistance in Populus. In the present study, the morphology and viability of colchicine-induced 2n pollen, triploid production by crossing induced 2n pollen, and identification of genetic constitution of colchicine-induced 2n pollen were conducted in Populus canescens based on optimizing technology for inducing chromosome doubling in pollen. We found that the meiotic stage, injection time, and the interaction between the meiotic stage and injection time had highly significant effects on the 2n pollen produc
View details →Negative / Null Result ReportOpen accessDentistry
Azam Valian, Zahra Jaber Ansari, Mohammad Moien Rezaie et al. · 2021 · BMC Oral Health
Abstract Background Esthetic dental restorations have gained increasing popularity. The surface of restorations should be smooth enough to achieve maximum esthetics and prevent the adhesion of microorganisms and food particles. This study aimed to assess the surface roughness and color change of composite specimens following airflow usage. Methods In this in vitro, experimental study, 30 Tokuyama composite discs were fabricated and randomly divided into three groups (n = 10) for the use of airflow with calcium carbonate/bicarbonate powder and conventional polishing with FlexiDisc. The surface
View details →Negative / Null Result ReportOpen accessMedicine
Mustafa Umut Somuncu, Huseyin Karakurt · 2019 · Türk Kardiyoloji Derneği Arşivi
Objective: Primary prevention of sudden cardiac death in ST-elevation myocardial infarction (STEMI) is a complicated issue due to the highly heterogeneous population. The effect of T-wave alternans (TWA) on cardiac mortality has been examined in various populations, most often in patients with a high risk of fatal arrhythmia, such as patients with a low left ventricular ejection fraction (LVEF). The aim of the present study was to investigate the prevalence of TWA and its relationship to cardiac mortality in young STEMI patients with preserved LVEF. Methods: A total of 108 STEMI patients with
View details →