21,309 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
López-de la Rosa A, Díez-Montero C, Martínez-Plaza E et al. · 2024 · Ophthalmology and therapy
Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of…
View details →Fitzgerald LS, Reynoso Spurrier CS, Lau NJ et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Mitochondria are key regulators of metabolism and ATP supply in skeletal muscle, while circadian rhythms influence many physiological processes. However, whether mitochondrial function is intrinsically regulated in a circadian manner in…
View details →Fernández-Ruiz M, Sánchez Moreno B, Santiago Almeda J et al. · 2023 · Transplant infectious disease : an official journal of the Transplantation Society
Previous studies have suggested that exposure to statins confers a protective effect in bloodstream infection (BSI) due to the anti-inflammatory and immunomodulatory properties attributed to these lipid-lowering drugs. Scarce evidence is…
View details →Vilk Ayalon N, Omer Vilk N, Sompolinsky Y et al. · 2026 · Reproductive health
BACKGROUND: Frozen embryo transfer (FET) is widely used due to its safety and effectiveness. However, it has been associated with an increased risk of large for gestational age (LGA) infants. Proposed mechanisms include effects of embryo…
View details →Agudelo LR, Yarmush G, Kumar S et al. · 2025 · Biology
Accelerating healing is a clinical goal in both acute and chronic non-healing skin wounds. We leveraged the public Recon database, which seeks to aggregate all of the metabolic pathways in the human body, to uncover whether increasing the…
View details →Sandoval-Alarcón S, Bäumle R, Castellucci HI · 2025 · Applied ergonomics
Dentists face various occupational demands that heighten their risk of developing work-related musculoskeletal disorders (WMSDs), including prolonged static postures, repetitive movements, unsuitable dental instruments, extended work…
View details →Warren WG, Papagianni EP, Hale E et al. · 2022 · Frontiers in pharmacology
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can…
View details →Khalid E, Vijayan MM · 2025 · Frontiers in endocrinology
Introduction Although the Crh-Crhr1 system is the proximal trigger for the stressor-induced corticosteroid release, its role in initiating the fight-or-flight response to an acute stressor is unclear. We hypothesized that the Crh-Crhr1…
View details →Ouerghi N, Abassi W, Jebabli N et al. · 2026 · Sports (Basel, Switzerland)
The study investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness, hormonal, and psychological markers in adolescents. Twenty-eight healthy male adolescents were randomized to a HIIT group or a…
View details →Toledo FV, Meletti JFA, Silva LMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)
Introduction Surgery remains one of the most important treatments for breast cancer. In this context, the quality of postoperative recovery has become a key concern. Adequate control of acute pain is essential to optimize patient comfort…
View details →Salihu AT, Usman JS, Hill KD et al. · 2023 · Experimental brain research
The ability to control balance and prevent falls while carrying out daily life activities may require a predominantly controlled (cognitive) or automatic processing depending on the balance challenge, age, or other factors. Consequently,…
View details →Tatsuoka Y, Zembrzuski KJ, Natalini JG et al. · 2025 · Journal of clinical medicine
Background: Primary graft dysfunction (PGD) is the leading cause of early mortality after lung transplantation. Albumin is commonly used during lung transplantation to maintain intravascular volume while minimizing total intravenous fluid…
View details →Berge M, Hultgren O, Hugosson S et al. · 2026 · Scientific reports
There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently no reliable biomarkers to predict which patients are likely to benefit from the…
View details →Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…
View details →Jobson I, Vo NTN, Kujawinski E et al. · 2025 · Bioelectronic medicine
Background In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocure™, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they extend median…
View details →Johnson KV, Steenbergen L · 2025 · Npj mental health research
The burgeoning field of the microbiome-gut-brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more…
View details →Nimkulrat SD, Wagner MR, Waters BJ et al. · 2025 · Scientific reports
RNA binding proteins (RBPs) are increasingly being recognized as important regulators of pancreatic β cells' identity and function. We identified the poly-A binding RBP, CPEB1, as a potential new regulator linked to β cell failure in…
View details →Ó Dúinín E, Steopan JK, Kessler K et al. · 2025 · Scientific reports
We investigated the effects of cognitive training with transcranial random noise stimulation (tRNS) applied to the intraparietal sulcus (IPS) or dorsolateral prefrontal cortex (DLPFC) on improving a multidirectional number line estimation…
View details →Cesanelli L, Venckunas T, Minderis P et al. · 2026 · Antioxidants (Basel, Switzerland)
Background/Objectives : This study aimed to evaluate the effects of short-term broccoli powder supplementation on metabolically demanding exercise performance, muscle power, and blood lactate recovery. It also investigated broccoli…
View details →Turton S, Hawkins PCT, Muller-Pollard C et al. · 2025 · Psychopharmacology
Rationale It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used…
View details →Caballero P, Prieto-Amador M, Martínez-Guitarte J · 2022 · Preprint
Abstract Pesticides are an environmental problem. The search for new pest control methods has focused on compounds with low or no toxic effects in non-target organisms. Analogs of the juvenile hormone (JH) interfere endocrine system of…
View details →Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…
View details →Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)
α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…
View details →Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health
This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…
View details →Galante H, Czaczkes TJ · 2022 · Preprint
Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often boost learning, foraging, or recruitment.…
View details →Winter AL, Peter M, Thunell E et al. · 2026 · Neural plasticity
Absence of sensory input is associated with alterations in brain morphology; mainly in or near cerebral regions normally devoted to processing of the missing sense. However, multiple recent studies demonstrate that the only consistent…
View details →Chen P, Lv J · 2024 · Nephrology (Carlton, Vic.)
This mini-review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP-IgAN regarding glucocorticoid…
View details →Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal
Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…
View details →Galante H, Lane SJ, Elderbrock EK et al. · 2026 · Integrative organismal biology (Oxford, England)
Organisms in natural environments often undergo life history stage transitions that optimize behaviors (i.e., migration, reproduction, and foraging) with environmental conditions. These changes in behavior are facilitated by changes in…
View details →García MA, Aceituno A, Díaz NB et al. · 2025 · Pharmaceutics
Background/Objectives: The static in vitro permeability assay based on cell monolayers has been widely used in the pharmaceutical industry and recognized by regulatory agencies as a surrogate method for BCS classification. However, the…
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