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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen access

PCSK9 and breast cancer survival: a Mendelian Randomization study

Pott J, Mason A, Salo V et al. · 2025 · Preprint

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is well known for its causal effects on the lipid metabolism. A recent study identified an association between rs562556 within PCSK9 and breast cancer survival (BCS). It was…

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Negative / Null Result ReportOpen accessMedicine

Vibration-Induced Nystagmus in Patients with Ménière's Disease: Is There a Correlation to Endolymphatic Hydrops?

Lorente-Piera J, Blanco M, Manrique-Huarte R et al. · 2025 · Audiology research

Background/Objectives : Skull vibration-induced nystagmus (SVIN) is a rapid bedside test that reveals vestibular asymmetry. Its clinical utility in Ménière's disease (MD) remains controversial, particularly regarding its association with…

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Negative / Null Result ReportOpen accessMedicine

Outcomes and experiences of music workshops for adolescents with depression and anxiety: An exploratory noncontrolled trial in Bogotá.

Gómez-Restrepo C, Roldan MC, Ariza-Salazar K et al. · 2024 · BMC research notes

Objective Adolescents frequently experience mental distress. However, there is little research on community activities that help adolescents recover from depression and anxiety. This study investigated the outcomes and experiences of music…

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Negative / Null Result ReportOpen accessMedicine

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster-Randomised Trial.

Diarra NH, Dicko Y, Roschnik N et al. · 2025 · Maternal & child nutrition

A cluster-randomised controlled trial was conducted in 60 communities in southern Mali to evaluate the impact of micronutrient powders (MNP) combined with seasonal malaria chemoprevention (SMC) on anaemia (primary endpoint), Plasmodium…

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Negative / Null Result ReportMedicine

Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.

Bierut L, Biroli P, Galama TJ et al. · 2023 · Journal Of Economic Psychology

Smoking is one of the leading causes of preventable disease and death in the U.S., and it is strongly influenced both by genetic predisposition and childhood adversity. Using polygenic indices (PGIs) of predisposition to smoking, we…

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Negative / Null Result ReportOpen accessMedicine

Sensory sensitivity and visual discomfort are not associated with altered gamma oscillations: A test of the excitation-inhibition hypothesis.

Sumner P, Powell G, Price A et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Many people experience aversive hypersensitivity (discomfort/visual stress) to stimuli such as bright lights, striped patterns, strobing, motion, or complex visual scenes such as supermarkets. Such sensory hypersensitivity is often…

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Negative / Null Result ReportMedicine

Weight cycling and cancer risk in the Sister Study.

Stevens VL, Priest J, Wilkerson J et al. · 2026 · American journal of epidemiology

Weight cycling, when weight is repeatedly lost intentionally and then regained, may perturb biological processes that could influence cancer development. However, results from epidemiologic studies of weight cycling are mixed and provide…

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Negative / Null Result ReportMedicine

The impact of recreational cannabis retailer allocation on emergency department visits: A natural experiment utilizing lottery design.

Bai Y, Cao P, Kim C et al. · 2025 · The International journal on drug policy

Background In October 2018, Canada legalized recreational cannabis, with Ontario distributing retailer licenses through a lottery system in 2019. This study investigates the impact of recreational cannabis retailer allocation on emergency…

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Negative / Null Result ReportMedicine

Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning.

Lupien SJ, Roy DC, Raymond C et al. · 2020 · Development and psychopathology

Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with…

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Negative / Null Result ReportOpen accessMedicine

The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.

Jackson E, Riley T, Overton PG · 2026 · PloS one

Background Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for…

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Negative / Null Result ReportOpen accessMedicine

Acceptance of mixed gambles is sensitive to the range of gains and losses experienced, and estimates of lambda (λ) are not a reliable measure of loss aversion: Reply to André and de Langhe (2020).

Walasek L, Mullett TL, Stewart N · 2021 · Journal of experimental psychology. General

Walasek and Stewart (2015) demonstrated that loss aversion estimated from fitting accept-reject choice data from a set of 50-50 gambles can be made to disappear or even reverse by manipulating the range of gains and losses experienced in…

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Negative / Null Result ReportOpen accessMedicine

A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee.

Benedetti MH, Lu B, Zhu M · 2024 · Biometrical journal. Biometrische Zeitschrift

A concern surrounding marijuana legalization is that driving after marijuana use may become more prevalent. Survey data are valuable for estimating policy effects, however their observational nature and unequal sampling probabilities…

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Negative / Null Result Report

Low Exercise Capacity Is Independent Of LVMI Despite Significant Change In Diastolic Function In Young non complicated Hypertensive Patients

Asaad Hasan Noaman, Oday Al- Salihi · 2019 · Al-Kufa University Journal for Biology

Systemic hypertension is common disease that affect many organs specially the cardiovascular system. Left ventricle hypertrophy is the main cardiac structural remodeling that occur in response to hypertension, furthermore. The role of LVM…

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