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Browse the failure-mode index

21,742 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Maltodextrin as sucrose replacer: Effect of dextrose equivalence and sucrose/maltodextrin ratio on physical and sensory properties of non-fat whipped cream analogue

Yang J, Han Y · 2026 · Food Hydrocolloids.

The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…

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Negative / Null Result ReportMedicine

Efficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.

Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…

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Negative / Null Result ReportMedicine

Outcomes of secondary interventions in treatment of post-traumatic stiff shoulder in conservatively managed proximal humeral fractures: a scoping review.

Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science

Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…

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Negative / Null Result ReportMedicine

Postoperative syphilitic scleritis following strabismus surgery.

Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…

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Negative / Null Result ReportMedicine

Olfactory outcomes after primary endoscopic sinus surgery and dupilumab for post-operative recurrence in eosinophilic chronic rhinosinusitis.

Saito T, Hirose T, Haruna T et al. · 2026 · The Journal of laryngology and otology

Objective. To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for…

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Negative / Null Result ReportOpen accessMedicine

The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.

Song X, Wang Y, Chen H · 2026 · International journal of cardiology. Cardiovascular risk and prevention

Objective To identify distinct multi-year cognitive function trajectories in middle-aged and older Chinese adults with established cardiovascular disease (CVD) and evaluate their independent associations with all-cause mortality. Methods…

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Negative / Null Result ReportMedicine

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction.

Espehana A, Macfarlane G, Garden EM et al. · 2026 · Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Objectives Tumour Necrosis factor antagonists is a potent anti-inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in…

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Negative / Null Result ReportMedicine

Asialoglycoprotein receptor-1 promotes hyperandrogenism in polycystic ovary syndrome through direct interaction with FSHR, leading to the cAMP-PKA-CREB pathway inhibition.

Liu X, Shi J, Wang T · 2026 · Reproduction (Cambridge, England)

Polycystic ovary syndrome (PCOS) is a prevalent multifactorial disorder characterized by hormone dysregulation and follicular development defects. Asialoglycoprotein receptor 1 (ASGR1), a C-type lectin predominantly expressed on the…

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Negative / Null Result ReportOpen accessMedicine

Types of physical activity and applied outcome measures in physical activity interventions among patients with inflammatory bowel disease: a scoping review.

Fromberg EB, Brink MT, Villumsen M et al. · 2026 · BMC gastroenterology

BACKGROUND: While pharmacological treatments remain essential in inflammatory bowel disease (IBD), complementary approaches such as physical activity are increasingly being explored for their potential benefits. This scoping review aimed…

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Negative / Null Result ReportMedicine

Bridging the Gap from "Paper" to "Patient": An Overview and Quality Assessment of PET/CT-Based Radiomics for Prostate Cancer Using the Updated RQS 2.0.

Bian S, Yang Y, Wang Z et al. · 2026 · Academic radiology

Rationale and objectives To apply the updated Radiomics Quality Score (RQS 2.0) and the Radiomics Readiness Level (RRL) framework to systematically evaluate the methodological quality and clinical translation maturity of Positron-emission…

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Negative / Null Result ReportMedicine

Comparison of the Efficacy of Intra-Articular Polyacrylamide Hydrogel and the Cross-Linked Hyaluronic Acid/Chondroitin Sulfate Combination in Treating Advanced-Stage Knee Osteoarthritis.

Altıntaş M, Ateş O, Soy F et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Polyacrylamide hydrogel (PAAG) is still underresearched, and few human studies have validated its efficacy in knee osteoarthritis (OA), particularly in advanced stages. The aim of this study was to compare the…

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Negative / Null Result ReportMedicine

Improving Operative Note Documentation in Vascular Surgery: A Two-Cycle Closed-Loop Audit Following Introduction of Standardised Procedure-Specific Templates.

Mersal M, Amin A, Embaby OM et al. · 2026 · Annals of vascular surgery

Objective To evaluate completeness of operative note documentation in a vascular surgery service and to assess whether introduction of standardised procedure-specific templates was associated with improved documentation in a repeat audit…

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Negative / Null Result Report

Improvement in Beetroot’s ( Beta vulgaris ) Growth and Yield Parameters in Soils Fertilized with Maize ( Zea mays ) Biochar Under Drip Irrigation with Treated Wastewater

Mathapa BG, Gaba T, Mmolawa K · 2026 · Preprint

Global water scarcity due to climate change coupled with environmental pollution from artificial fertilizers threatens sustainable agricultural productivity. To address these challenges, innovative circular and sustainable agricultural…

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