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Browse the failure-mode index

21,300 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

ECG-Gated 4D-CTA Assessment of Intracranial Aneurysm Wall Dynamics and Longitudinal Size Change: An Exploratory Study.

Jankovič P, Chodzyński KJ, Vanrossomme AE et al. · 2026 · Neurology international

Background The risk stratification of unruptured intracranial aneurysms (UIAs) relies largely on static clinical and morphological parameters, which may not fully capture aneurysm-specific wall behavior. ECG-gated four-dimensional computed…

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Negative / Null Result ReportMedicine

Staphylococcal Cassette Chromosome <i>mec</i> (SCC<i>mec</i>) Natural Excision Frequencies and Its Contributing Factors in Variant SCC<i>mec</i> Type Prototypic Strains.

Mirza S, Fine L, McClure JA et al. · 2026 · Antibiotics (Basel, Switzerland)

Background Staphylococcus aureus acquires methicillin resistance genes through the SCC mec element. Although spontaneous SCC mec excision has been observed, its frequency, type-specific variation, and responsiveness to environmental…

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Negative / Null Result ReportMedicine

Maintenance of Subclinical Mycoplasma bovis Infections in American Bison (Bison bison) in the Absence of Detectable Transmission.

Buttke DE, Kaplan BS, Jones LC et al. · 2026 · Journal of wildlife diseases

Mycoplasma bovis is a growing threat to American bison (Bison bison) health and restoration efforts, causing significant mortality and disease in affected bison herds. Despite this, little is known about the epidemiology or clinical course…

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Negative / Null Result ReportMedicine

Analytical Performance, Spatial Dynamics and Clinically Meaningful Change Thresholds for Automated Non-invasive Tear Film Assessment Using the Oculus Keratograph 5M.

Oehring D · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose Non-invasive tear film metrics from automated topographers are used increasingly, yet device-specific analytical performance remains incompletely characterised. This study quantified the analytical performance of the Oculus…

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Negative / Null Result ReportMedicine

The Effects of Short-Term Post-Exposure to 3.6 GHz 5G Mobile Phone Electromagnetic Exposure on Static and Dynamic Postural Control in Healthy Adults: A Randomized Sham-Controlled Pilot Study.

Torkan A, Zoghi M, Foroughimehr N et al. · 2026 · Sensors (Basel, Switzerland)

The rapid global expansion of 5G technology has increased concerns regarding its potential health effects. Postural balance, a complex sensorimotor function reflecting central nervous system integrity, may be susceptible to electromagnetic…

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Negative / Null Result ReportOpen accessMedicine

Measurement Properties and Minimal Detectable Change of the 6-Min Step Test for Estimating Cardiorespiratory Fitness in Hospitalized Individuals After Stroke.

Aguiar Pavesi RO, Boening A, Meyrelles SDS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Background The 6-minuteute step test is an alternative for estimating cardiorespiratory fitness after stroke. Objective To investigate its measurement properties and minimal detectable change early after stroke. Methods Cross-sectional,…

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Negative / Null Result ReportMedicine

Effect of a Spinal Orthosis With Leaf Spring and Programmable Local Vibration on Kyphosis Angle and Trunk Muscle Strength in Hyperkyphosis: Development and Feasibility Study.

Keshavarzi F, Arazpour M, Behzadipour S · 2026 · JMIR biomedical engineering

Background The application of spinal orthoses and local vibration in the treatment of hyperkyphosis is a developing concept. Further research is needed to determine the impact of leaf springs and local vibration techniques on the…

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Negative / Null Result ReportOpen accessMedicine

Case Report: early regression and bladder-intact survival after limited-course immunotherapy-based systemic therapy in two patients with clinically staged bulky muscle-invasive bladder cancer.

Zhang S, Zhang H, Dong X et al. · 2026 · Frontiers in immunology

Background Radical cystectomy remains a standard curative treatment for muscle-invasive bladder cancer (MIBC). Bladder preservation after systemic therapy without immediate surgery remains investigational and requires careful patient…

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Negative / Null Result ReportOpen accessMedicine

Use of dual ART in individuals with different HBV serological patterns.

Swaine T, Bhagani S · 2026 · Current opinion in HIV and AIDS

Purpose of review Two-drug regimens (2DR) for antiretroviral therapy are increasingly being recommended for people living with HIV to reduce pill burden and reduce short and long-term toxicity. The exclusion of tenofovir and lamivudine or…

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Negative / Null Result ReportOpen accessMedicine

Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.

Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open

Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…

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Replication FailureMedicine

UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity Toward <i>N</i>-Hydroxypipecolic Acid.

Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)

N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…

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Failed Experiment ReportMedicine

Evaluation of leukocyte depletion filters for the removal of EpCAM-positive tumor cells during oncologic intraoperative blood salvage using CATUVAB<sup>®</sup>: an exploratory feasibility study.

Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology

Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…

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Methods Dead-EndOpen accessMedicine

Minimum Detectable Change and Minimal Clinically Important Difference for the Box and Block Test and Fugl-Meyer Assessment in Moderate to Severe Chronic Stroke.

Aaby D, Sullivan JE, Carmona C et al. · 2026 · Archives of rehabilitation research and clinical translation

Objectives To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT…

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Replication FailureOpen accessMedicine

Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness.

Zhou Y, Zhong Z, Mo H et al. · 2026 · Research and practice in thrombosis and haemostasis

Background Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity. Recent studies have…

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