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Browse the failure-mode index

21,300 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Sensory sensitivity and visual discomfort are not associated with altered gamma oscillations: A test of the excitation-inhibition hypothesis.

Sumner P, Powell G, Price A et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Many people experience aversive hypersensitivity (discomfort/visual stress) to stimuli such as bright lights, striped patterns, strobing, motion, or complex visual scenes such as supermarkets. Such sensory hypersensitivity is often…

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Negative / Null Result ReportMedicine

Weight cycling and cancer risk in the Sister Study.

Stevens VL, Priest J, Wilkerson J et al. · 2026 · American journal of epidemiology

Weight cycling, when weight is repeatedly lost intentionally and then regained, may perturb biological processes that could influence cancer development. However, results from epidemiologic studies of weight cycling are mixed and provide…

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Negative / Null Result ReportMedicine

The impact of recreational cannabis retailer allocation on emergency department visits: A natural experiment utilizing lottery design.

Bai Y, Cao P, Kim C et al. · 2025 · The International journal on drug policy

Background In October 2018, Canada legalized recreational cannabis, with Ontario distributing retailer licenses through a lottery system in 2019. This study investigates the impact of recreational cannabis retailer allocation on emergency…

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Replication FailureOpen accessMedicine

Medication Review and Enhanced Information Transfer at Discharge of Older Patients with Polypharmacy: a Cluster-Randomized Controlled Trial in Swiss Hospitals.

Grischott T, Rachamin Y, Senn O et al. · 2023 · Journal of general internal medicine

Background Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to…

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Negative / Null Result ReportOpen accessMedicine

Restricting facial mimicry does not impair emotion recognition or influence the evaluation of human affect vocalizations and instrumental sounds.

Wołoszyn K, Hohol M, Winkielman P · 2026 · Scientific reports

The embodied simulation approach predicts that restricting facial movements disrupts emotion recognition. Such effects have been reported for facial and whole-body emotional expressions, but findings remain inconsistent, and it is unclear…

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Negative / Null Result ReportOpen accessMedicine

Object relations are processed with, but not without, awareness.

Palgi S, Bester-Arest T, Faivre N et al. · 2025 · Neuroscience of consciousness

The scope of unconscious integration is widely debated. Here, we examined this question, focusing specifically on deciphering the relations between two associatively related objects, in a set of five behavioral and electrophysiological…

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Negative / Null Result ReportMedicine

Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning.

Lupien SJ, Roy DC, Raymond C et al. · 2020 · Development and psychopathology

Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with…

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Negative / Null Result ReportOpen accessMedicine

The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.

Jackson E, Riley T, Overton PG · 2026 · PloS one

Background Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for…

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Negative / Null Result ReportOpen accessMedicine

Acceptance of mixed gambles is sensitive to the range of gains and losses experienced, and estimates of lambda (λ) are not a reliable measure of loss aversion: Reply to André and de Langhe (2020).

Walasek L, Mullett TL, Stewart N · 2021 · Journal of experimental psychology. General

Walasek and Stewart (2015) demonstrated that loss aversion estimated from fitting accept-reject choice data from a set of 50-50 gambles can be made to disappear or even reverse by manipulating the range of gains and losses experienced in…

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Negative / Null Result ReportOpen accessMedicine

A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee.

Benedetti MH, Lu B, Zhu M · 2024 · Biometrical journal. Biometrische Zeitschrift

A concern surrounding marijuana legalization is that driving after marijuana use may become more prevalent. Survey data are valuable for estimating policy effects, however their observational nature and unequal sampling probabilities…

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Negative / Null Result ReportOpen accessMedicine

Does Conflictual Dialogue Improve a Story?

Berks JW, Williams MN · 2026 · Europe's journal of psychology

According to creative writing experts, adding conflict to dialogue improves story quality and audience reaction to that story. This idea draws from the widely held theory that conflict is vital for dramatic stories. Yet despite conflict's…

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