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Browse the failure-mode index

21,733 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A novel allele of B(A) blood group detected in a donor and a patient during a retrospective review of ABO group anomalies in a tertiary hospital.

Suksard K, Millard GM, Teravichitchainan U et al. · 2025 · Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

Background ABO discrepancies, inconclusive results between forward and reverse typing, are one of the significant challenges encountered in transfusion medicine. Their frequency and etiologies can vary among ethnicities. This study aimed…

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Negative / Null Result ReportOpen accessMedicine

MRI findings of an incidental ectopic posterior pituitary gland in an adult: Case report and review of T1 hyperintense lesions in the literature.

Hashem S, Murhega RB, Migabo PA · 2026 · Radiology case reports

The ectopic posterior pituitary represents a rare congenital malformation attributable to aberrant embryogenesis of the neurohypophysis. Although it may occur as an isolated anomaly, it is frequently concomitant with other congenital…

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Negative / Null Result ReportOpen accessMedicine

Variations in transcranial doppler among pediatric patients with sickle cell disease in the Brazilian Northeast: a cross-sectional study.

de Oliveira Castro Marques TR, Vidal SA, da Costa HA et al. · 2026 · Hematology, transfusion and cell therapy

Background Stroke, the most severe neurological complication of sickle cell disease, can result in irreversible sequelae and death. Transcranial Doppler combined with periodic blood transfusions reduces the chances of stroke by 90 %. In…

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Negative / Null Result ReportMedicine

The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case-control study.

Guarneri C, Reschini M, Pinna M et al. · 2024 · Journal of assisted reproduction and genetics

Purpose To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what extent this…

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Failed Experiment ReportOpen accessMedicine

Persistent cognitive deficits in ACL-injured athletes despite of rehabilitation: an observational longitudinal study.

Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living

Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…

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Negative / Null Result ReportOpen accessMedicine

Pre-Analytical and Analytical Challenges in Whole-Exome Sequencing of Formalin-Fixed Paraffin-Embedded Breast and Prostate Cancer Tissue: A Real-World Multicenter Study.

Rosa ML, Bordignon C, Schuch JB et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Formalin-fixed paraffin-embedded tissue is widely used in pathology and molecular diagnostics, yet its variable quality can critically influence the accuracy of sequencing-based analyses. This study investigated…

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Negative / Null Result ReportOpen accessMedicine

Comprehensive assessment of invalid and indeterminate results in Truenat MTB-RIF testing across sites under the national TB elimination program of India.

Gopalaswamy R, Kumar N, Vashistha H et al. · 2023 · Frontiers in public health

Introduction Truenat MTB-RIF assay (Truenat), a nucleic acid amplification test (NAAT), is a real-time polymerase chain reaction (RT-PCR) chip-based assay that can detect Mycobacterium tuberculosis ( Mtb ) and rifampicin (RIF) drug…

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Negative / Null Result ReportMedicine

Dietary Iron Intake and Risk of Gastric Cancer.

Pham YT, Nguyen BN, Nguyen TG et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Iron is one of the essential elements for human life. Prior studies provided inconclusive results about the association between dietary iron intake and gastric cancer risk. We determined the association between dietary iron…

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Negative / Null Result ReportOpen accessMedicine

Rare Occurrence of Myxoma in Heart Transplant Recipient: A Case Report.

Gutowska A, Bohdan M, Radtke-Łysek A et al. · 2026 · The American journal of case reports

BACKGROUND Cardiac myxomas are the most common primary cardiac tumors in the general population but are exceedingly rare in orthotopic heart transplant recipients. Fewer than 5 cases have been reported. Their pathogenesis in the setting of…

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Negative / Null Result ReportOpen accessMedicine

T174M-M235T <i>AGT</i> Gene Haplotypes in Women with Pre-Eclampsia from Northwest Mexico: A Pilot Case-Control Study.

Portillo-Gallo JH, Sánchez-González JM, Saldaña-Cruz AM et al. · 2026 · Current issues in molecular biology

Pre-eclampsia is a Hypertensive Disorder of Pregnancy (HDP) characterized by hypertension and proteinuria, affecting 2-8% of pregnancies worldwide and constituting a major public health concern. Genes of the renin-angiotensin system have…

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Negative / Null Result ReportOpen accessMedicine

Infectious potential and circulation of SARS-CoV-2 in wild rats.

Beissat K, Lattard V, Picard-Meyer E et al. · 2025 · PloS one

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a wide range of animal species (pets, mink…) have been naturally infected with this betacoronavirus. The emergence of new variants has…

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Negative / Null Result ReportOpen accessMedicine

Hierarchical Classification of Factors Associated With Noninvasive Prenatal Testing Failures and Its Impact on Pregnancy Outcomes.

Xie J, Jiang Y, Zhou Y et al. · 2024 · Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

Objective To conduct a hierarchical classification analysis of the nonreportable results of noninvasive prenatal testing in an attempt to reduce failure rates and provide pregnant women with accurate information to alleviate their anxiety.…

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Negative / Null Result ReportMedicine

Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.

Abdo M, Kunisaki KM, Morris A et al. · 2026 · AIDS research and human retroviruses

People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments.…

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Negative / Null Result ReportOpen accessMedicine

Challenges in Results Robustness of Trials with Missing Data for the Primary Endpoint: Insights from Coronary Balloon/Stent Trials.

Lang X, Zhao Y, Zhu Y et al. · 2025 · Risk management and healthcare policy

Background To assess the consequence of different degrees of missing primary endpoint data for randomized controlled trials and to find the influence factors. Methods PubMed, Cochrane Library, EMBASE and ClinicalTrials.gov were searched up…

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Negative / Null Result ReportMedicine

Polygene by environment interactions predicting depressive outcomes.

Grillo AR · 2025 · American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene-by-environment (G × E) interactions influence depression risk, and further, that depression is…

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