Negative / Null Result ReportOpen accessSocial Sciences
Laetitia Radder, Xiliang Han · 2015 · Journal of Applied Business Research (JABR)
This study determined whether Pine and Gilmores four experience economy realms (education, entertainment, escapism and esthetics) were represented by visitors experiences of three South African heritage museums, evaluated whether their experience expectations associated with the experience realms had been met, and examined the relationship between the latter, satisfaction and behavioral intentions. In addition, the relationship between personal and trip-related factors and the experience realms was investigated. Exploratory and confirmatory factor analyses identified three experience realms -
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sarah J. Marzi, Karen Sugden, Louise Arseneault et al. · 2018 · American Journal of Psychiatry
OBJECTIVE: DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jan C. van Ours, Lenny Stoeldraijer · 2011 · De Economist
Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age…
View details →Negative / Null Result ReportOpen accessEngineering
Alfredo Schiavone Panni, Simone Cerciello, Nicola Maffulli et al. · 2010 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Predisposing factors to objective patellar instability include trochlear dysplasia, patella alta, patellar tilt and elevated tibial tuberosity-femoral groove distance. The shape of the patella is classically not considered a predisposing factor. Anomalies of dynamic and static factors, including excessive patellar height, tibial tubercle lateralisation or trochlear dysplasia, may influence the development of the patella. METHODS: One hundred and five patients (140 knees) with objective patellar instability were retrospectively reviewed to identify a possible association between the ab
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jennifer B. Dowd, Megan Todd · 2011 · The Journals of Gerontology Series B
OBJECTIVES: Measurement of health inequalities based on self-reports may be biased if individuals use response scales in systematically different ways. We use anchoring vignettes to test and adjust for reporting differences by education,…
View details →Negative / Null Result ReportOpen accessMedicine
Ulf Neumann, Mike Ufer, Laura H. Jacobson et al. · 2018 · EMBO Molecular Medicine
The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti‐Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states. The BACE‐1 inhibitor CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Ciarán Hickey, Simon Trebst · 2019 · Nature Communications
In the field of quantum magnetism, the exactly solvable Kitaev honeycomb model serves as a paradigm for the fractionalization of spin degrees of freedom and the formation of [Formula: see text] quantum spin liquids. An intense experimental search has led to the discovery of a number of spin-orbit entangled Mott insulators that realize its characteristic bond-directional interactions and, in the presence of magnetic fields, exhibit no indications of long-range order. Here, we map out the complete phase diagram of the Kitaev model in tilted magnetic fields and report the emergence of a distinct
View details →Negative / Null Result ReportOpen accessPsychology
Corinna E. Löckenhoff, Wayne Chan, Robert R. McCrae et al. · 2014 · Journal of Cross-Cultural Psychology
Numerous studies have documented subtle but consistent sex differences in self-reports and observer-ratings of five-factor personality traits, and such effects were found to show well-defined developmental trajectories and remarkable similarity across nations. In contrast, very little is known about perceived gender differences in five-factor traits in spite of their potential implications for gender biases at the interpersonal and societal level. In particular, it is not clear how perceived gender differences in five-factor personality vary across age groups and national contexts and to what
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Martin Browning, Mette Ejrnæs, Javier Álvarez · 2010 · The Review of Economic Studies
All empirical models of earnings processes in the literature assume a good deal of homogeneity. In contrast to this we model earnings processes allowing for lots of heterogeneity between agents. We also introduce an extension to the linear…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan Hagel, Friedhelm Bach, Thorsten Brenner et al. · 2022 · Intensive Care Medicine
PURPOSE: Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. METHODS: Randomized, multicenter, controlled…
View details →Negative / Null Result ReportMedicine
RBC Kavia, Dirk De Ridder, Cris S. Constantinescu et al. · 2010 · Multiple Sclerosis Journal
BACKGROUND: Bladder dysfunction is a common feature of multiple sclerosis (MS). OBJECTIVE: In this study we aimed to assess the efficacy, tolerability and safety of Sativex(®) (nabiximols) as an add-on therapy in alleviating bladder…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Nicole J. Olynk, Glynn T. Tonsor, Christopher A. Wolf et al. · 2010 · AgEcon Search (University of Minnesota, USA)
A choice experiment was used to determine consumer value for verification of livestock production process attributes. Willingness to pay for verification of production process attributes varied for both milk and pork chops across…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Robert Christley · 2010 · The Open Epidemiology Journal
It is well recognised that low statistical power increases the probability of type II error, that is it reduces the probability of detecting a difference between groups, where a difference exists. Paradoxically, low statistical power also increases the likelihood that a statistically significant finding is actually falsely positive (for a given p-value). Hence, ethical concerns regarding studies with low statistical power should include the increased risk of type I error in such studies reporting statistically significant effects. This paper illustrates the effect of low statistical power by c
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
C. Abel, N. J. Ayres, G. Ban et al. · 2017 · Physical Review X
We report on a search for ultralow-mass axionlike dark matter by analyzing the ratio of the spinprecession frequencies of stored ultracold neutrons and 199 Hg atoms for an axion-induced oscillating electric dipole moment of the neutron and an axion-wind spin-precession effect. No signal consistent with dark matter is observed for the axion mass range 10 -24 m a 10 -17 eV. Our null result sets the first laboratory constraints on the coupling of axion dark matter to gluons, which improve on astrophysical limits by up to 3 orders of magnitude, and also improves on previous laboratory constraints
View details →Negative / Null Result ReportOpen accessNeuroscience
Sean P. Burns, Dajun Xing, Robert Shapley · 2011 · Journal of Neuroscience
Gamma-band (25-90 Hz) peaks in local field potential (LFP) power spectra are present throughout the cerebral cortex and have been related to perception, attention, memory, and disorders (e.g., schizophrenia and autism). It has been…
View details →Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Ramon Casanova, Sudhir Varma, Brittany Simpson et al. · 2016 · Alzheimer s & Dementia
INTRODUCTION: Recently, quantitative metabolomics identified a panel of 10 plasma lipids that were highly predictive of conversion to Alzheimer's disease (AD) in cognitively normal older individuals (n = 28, area under the curve [AUC] =…
View details →Negative / Null Result ReportMedicine
Rebecca Erwin Wells, Rebecca Burch, Randall H. Paulsen et al. · 2014 · Headache The Journal of Head and Face Pain
OBJECTIVE: Our objective was to assess the safety, feasibility, and effects of the standardized 8-week mindfulness-based stress reduction (MBSR) course in adults with migraines. BACKGROUND: Stress is a well-known trigger for headaches.…
View details →Replication FailureOpen accessNursing
Karen Rees, Louise Hartley, Camilla Day et al. · 2013 · Cochrane Database of Systematic Reviews
BACKGROUND: Selenium is a key component of a number of selenoproteins which protect against oxidative stress and have the potential to prevent chronic diseases including cardiovascular disease (CVD). However, observational studies have…
View details →Negative / Null Result ReportSocial Sciences
Steven W. Hemelt, Dave E. Marcotte · 2011 · Educational Evaluation and Policy Analysis
In this paper we review recent increases in tuition at public institutions and estimate impacts on enrollment. We use data on all U.S. public 4-year colleges and universities from 1991 to 2006 and illustrate that tuition increased…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Carter J. Wilson, Wing‐Yiu Choy, Mikko Karttunen · 2022 · International Journal of Molecular Sciences
The development of AlphaFold2 marked a paradigm-shift in the structural biology community. Herein, we assess the ability of AlphaFold2 to predict disordered regions against traditional sequence-based disorder predictors. We find that AlphaFold2 performs well at discriminating disordered regions, but also note that the disorder predictor one constructs from an AlphaFold2 structure determines accuracy. In particular, a naïve, but non-trivial assumption that residues assigned to helices, strands, and H-bond stabilized turns are likely ordered and all other residues are disordered results in a dra
View details →Negative / Null Result ReportOpen accessMedicine
Jessica Lieffers, Vickie E. Baracos, Marcy Winget et al. · 2010 · Cancer
BACKGROUND: Cancer survival is related to features of the primary malignancy and concurrent presence of nonmalignant diseases (comorbidities), including weight-related conditions (obesity, weight loss). The Charlson and Elixhauser methods…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Julie Morand‐Ferron, Ella F. Cole, James E.C. Rawles et al. · 2011 · Behavioral Ecology
Ecological and evolutionary drivers of innovativeness among species are relatively well studied, but the significance of similar variation within species is much less well understood. Using automated foraging devices, we conducted the…
View details →Negative / Null Result ReportNeuroscience
Ali Jannati, John M. Gaspar, John J. McDonald · 2013 · Journal of Experimental Psychology Human Perception & Performance
Salient distractors delay visual search for less salient targets in additional-singleton tasks, even when the features of the stimuli are fixed across trials. According to the salience-driven selection hypothesis, this delay is due to an…
View details →Replication FailurePsychology
Briana B. Morrison, Lauren E. Margulieux, Mark Guzdial · 2015
Recent empirical results suggest that the instructional material used to teach computing may actually overload students' cognitive abilities. Better designed materials may enhance learning by reducing unnecessary load. Subgoal labels have…
View details →Negative / Null Result ReportDecision Sciences
Moin Khan, Nathan Evaniew, Mark Gichuru et al. · 2016 · The American Journal of Sports Medicine
BACKGROUND: High-quality, evidence-based orthopaedic care relies on the generation and translation of robust research evidence. The Fragility Index is a novel method for evaluating the robustness of statistically significant findings from…
View details →Negative / Null Result ReportOpen accessMedicine
Richard Aplenc, Soheil Meshinchi, Lillian Sung et al. · 2020 · Haematologica
New therapeutic strategies are needed for pediatric acute myeloid leukemia (AML) to reduce disease recurrence and treatment-related morbidity. The Children’s Oncology Group Phase III AAML1031 trial tested whether the addition of bortezomib…
View details →Negative / Null Result ReportMedicine
Alexandra Philipsen, Thomas Jans, Erika Graf et al. · 2015 · JAMA Psychiatry
IMPORTANCE: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with high prevalence in adulthood. There is a recognized need to assess the efficacy of psychotherapy in adult ADHD. OBJECTIVE: To evaluate the…
View details →Negative / Null Result ReportOpen accessPsychology
Jan Alewyn Nel, Velichko H. Valchev, Sebastiaan Rothmann et al. · 2011 · Journal of Personality
The present study, part of the development of the South African Personality Inventory (SAPI), explores the implicit personality structure in the 11 official language groups of South Africa by employing a mixed-method approach. In the…
View details →Negative / Null Result ReportOpen accessMedicine
Benjamin W. Chaffee, Shannon Lea Watkins, Stanton A. Glantz · 2018 · PEDIATRICS
BACKGROUND: It has been shown that never-smoking adolescents who try electronic cigarettes (e-cigarettes) are at increased risk of subsequent conventional cigarette smoking. We evaluated associations between e-cigarette use and progression…
View details →Negative / Null Result ReportMaterials Science
Yun Yu, Hongwei Wu · 2010 · Industrial & Engineering Chemistry Research
Due to the presence of amorphous structure in microcrystalline cellulose, the reactivity of microcrystalline cellulose exhibits a considerable reduction in the initial stage during hydrolysis in hot-compressed water (HCW). Further analysis…
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