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Browse the failure-mode index

21,720 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants.

Ramli FF, Villa LM, Martens MAG et al. · 2026 · Scientific reports

Ebselen has been shown to induce a positive emotional processing bias and brain neurochemistry in healthy volunteers. However, little is known about its effects on resting-state functional connectivity (rs-FC) in depressed patients who…

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Negative / Null Result ReportMedicine

Autonomic Nervous System Response to Intermittent Theta-Burst Transcranial Magnetic Stimulation in Those With Major Depressive Disorder​​​: A Randomized Sham-Controlled Comparison of Heart Rate Variability and Pupillary Light Reflex.

Sharma M, McCall WV, Rosenquist PB · 2026 · The journal of ECT

Objectives To examine the acute and longitudinal effects of repetitive transcranial magnetic stimulation (rTMS) on-autonomic nervous system measures (ANS)-heart rate variability (HRV) and pupillary light reflex (PLR)-in adults with major…

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Negative / Null Result Report

Differential Effects of Cultural Performing Arts on Anti-Aging Biomarkers and Well-Being: A Non- Randomized Pre–Post Comparative Study of Traditional Noh/Kyogen and Comedy

Tomisawa T, Nanashima N, In N et al. · 2026 · Preprint

Abstract This study examined how cultural performing arts affect psychological well-being and stress-related biomarkers, comparing traditional Japanese Noh and Kyogen (TNKP) with live comedy (CLP). Participants aged 18–64 years were…

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Negative / Null Result ReportMedicine

[Weight change following a self-selected, type-tailored lifestyle modification program for employees with suspected visceral fat accumulation: A single-arm before-after study].

Hari S, Kumamoto M, Suzuki M et al. · 2026 · Sangyo eiseigaku zasshi = Journal of occupational health

Objectives This single-arm before-after study examined short-term changes in body weight following a 28-day self-selected, type-tailored lifestyle modification program implemented before workplace health checkups. Participants…

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Negative / Null Result ReportMedicine

Sun Safety Intervention for Elementary School Students.

Moeckel C, Anderson R, Krnajic L et al. · 2026 · Pediatric dermatology

This study evaluated the impact of an elementary school-based intervention that aimed to improve sun safety knowledge and behaviors among third- and fourth-grade students in Pennsylvania through an educational video, t-shirt design…

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Negative / Null Result ReportMedicine

Fundamental Frequency, Voice Quality, Intensity, and Syllable Rate in Hebrew Child-Directed Speech: Acoustic Adaptations From Early to Middle Childhood.

Sinvani RT · 2026 · Journal of voice : official journal of the Voice Foundation

Child-directed speech (CDS) prosodic modifications are well-documented in infancy, but their persistence into middle childhood remains understudied. To address this gap, this study examined developmental changes in acoustic properties of…

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Negative / Null Result ReportOpen accessMedicine

Diurnal Variations in Anterior and Posterior Corneal Thickness and Curvature in Healthy Eyes: Global and Sector-Based Metrics and Lifestyle Associations.

Barberán-Bernardos L, Ariza-Gracia MA, Büchler P et al. · 2026 · Life (Basel, Switzerland)

This study aims to characterize diurnal changes in corneal geometry of the anterior and posterior cornea in healthy eyes using global and sector-based metrics, and to explore their associations with lifestyle-related factors. A prospective…

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Negative / Null Result ReportMedicine

Peripapillary Retinal Nerve Fibre and Ganglion Cell Layer Changes Following Intravitreal Aflibercept 8 mg Therapy in Neovascular Age-Related Macular Degeneration: A Longitudinal OCT Study.

Volpe G, Bonanata M, Peyla A et al. · 2026 · Ophthalmology and therapy

Introduction Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard of care for neovascular age-related macular degeneration (nAMD) and other retinal vascular diseases. However, transient post-injection…

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Negative / Null Result ReportMedicine

Two-year follow-up of musculoskeletal outcomes and quality of life in patients with mucopolysaccharidosis type IV and VI.

Genç E, Bilekyiğit Kurt C, Evrim Karadağ Saygi N et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM

Objectives Musculoskeletal abnormalities are common to mucopolysaccharidoses (MPS) and can negatively affect the patient's quality of life. Data on course of musculoskeletal findings of MPS type IVA and VI are very insufficient. This study…

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Failed Experiment ReportMedicine

Impact of ETI therapy on bone health, body composition and cardiopulmonary fitness in children with CF.

Holden A, Burns P, Devenny A et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Background Improved survival in cystic fibrosis (CF) has shifted clinical focus toward late complications, including altered body composition, bone health and cardiopulmonary fitness. The effects of Elexacaftor/Tezacaftor/Ivacaftor (ETI)…

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Negative / Null Result ReportOpen accessMedicine

Salivary characteristics and oral microbial dynamics in patients before and after maxillectomy with obturator prosthesis: a pilot prospective cohort study.

Asbi T, Mayer Y, Sarikov R et al. · 2026 · The Saudi dental journal

Maxillectomy produces extensive oral and maxillofacial defects that disrupt normal physiology and often require obturator prostheses for functional and aesthetic rehabilitation. Although these devices are routinely used, their influence on…

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