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WASTE Journal

Browse the failure-mode index

21,283 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

A Phase II Study of FOLFIRI Plus Ziv-Aflibercept After Trifluridine/Tipiracil Plus Bevacizumab in Patients with Metastatic Colorectal Cancer: WJOG 11018G.

Matsumoto T, Yamamoto Y, Kotaka M et al. · 2024 · Targeted oncology

Background Non-inferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) to irinotecan/fluoropyrimidine plus BEV in metastatic colorectal cancer was investigated in the phase III TRUSTY study, and we conducted a phase II study…

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Negative / Null Result ReportMedicine

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.

Webers C, Ortolan A, Sepriano A et al. · 2023 · Annals of the rheumatic diseases

Objective To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…

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Negative / Null Result ReportOpen accessMedicine

Perioperative immunotherapy combined with standard therapy for human epidermal growth factor receptor 2-positive locally advanced gastric cancer: A case report.

Ma XT, Yao GY, Li JL et al. · 2025 · World journal of clinical oncology

Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regimens are currently…

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Negative / Null Result ReportOpen accessMedicine

Effect of Two Post-Curing Units on the Physico-Mechanical Properties of 3D-Printed Resins for Permanent Crown Fabrication.

Mujayridi M, Matinlinna J, Silikas N · 2026 · Materials (Basel, Switzerland)

Three-dimensional (3D) printing is increasingly used for the fabrication of definitive crowns; however, whether specific post-curing hardware is mandatory for clinical success remains a practical concern. This study provided a practical…

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Negative / Null Result ReportMedicine

Effect of oral health education by audio aids, braille, tactile models on the oral health status of visually impaired adults: a 6-month follow-up study.

Yıldırım D, Zorluoğlu SL, Navruz ES et al. · 2026 · BMC oral health

Background Oral and dental health education is typically delivered using visual methods on jaw models. However, these methods are insufficient for individuals with visual impairments. This study aims to contribute to the oral and dental…

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Negative / Null Result ReportOpen accessMedicine

Focus on comfort: the effect of focus language on postoperative hospital stay compared to the Numeric Rating Scale in children receiving postoperative care-a pre-post study.

Angenent A, Maaskant JM, Nieland L et al. · 2026 · European journal of pediatrics

This study evaluates the effect of a comfort assessment using focus language compared with pain assessment using the Numeric Rating Scale (NRS) on postoperative length of stay (LOS), analgesic use and patient and parental satisfaction.…

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Negative / Null Result ReportOpen accessMedicine

Early outcomes of transverse perineal support in obstructed defecation syndrome with pathological perineal descent; a prospective cohort study.

Azmy Basiouny HM, Shafik AA, Elbarmelgi MY et al. · 2026 · BMC surgery

Background While current surgical approaches for obstructed defecation syndrome (ODS) primarily target rectocele and rectal intussusception, excessive perineal descent (PD) may contribute to persistent symptoms and suboptimal surgical…

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Negative / Null Result ReportOpen accessMedicine

The Reciprocal Risk Relationship of Dental Caries with NAFLD and Liver Fibrosis: Combined Evidence from the NHANES Study and Mendelian Randomization Analysis.

Xu L, Wang X, Meng X et al. · 2026 · Oral health & preventive dentistry

Purpose To explore the relationship between dental caries and non-alcoholic fatty liver disease (NAFLD) and its advanced stage of liver fibrosis, and to confirm causality by employing a bidirectional two-sample Mendelian Randomization (MR)…

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Negative / Null Result ReportMedicine

Analysis of US Pediatric Pharmacists Incomes: A Gender Comparison Survey Study by the Pediatric Pharmacy Association, Practice-Based Research Network.

Popovici I, Carvajal MJ, Higgins T et al. · 2026 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Objectives While gender disparities in the US workforce have received substantial attention, income inequalities among subspecialty pharmacists remain understudied. This study aimed to develop a professional profile of pediatric…

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Negative / Null Result ReportOpen accessMedicine

The potential clinical significance of immunomodulation of immune and inflammatory responses involving selected adipokines in patients with ovarian cancer - preliminary studies.

Stępień S, Morawiec ML, Smycz-Kubańska M et al. · 2026 · Frontiers in oncology

Ovarian cancer (OC) is a major clinical problem in gynaecological oncology, characterised by difficulties in early diagnosis, which contributes to the high mortality rate from OC. Therefore, the search for new biological markers continues,…

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Negative / Null Result ReportOpen accessMedicine

Validation of the C-WATCH score for predicting severity in patients with upper gastrointestinal bleeding at a tertiary public hospital in Lima, Peru.

Espinoza-Ríos J, Ruiz-Cortez R, Santiago B et al. · 2026 · BMC gastroenterology

Background Upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, with mortality rates reaching 14% in some settings. Despite advances in management, mortality has remained relatively…

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Negative / Null Result ReportOpen accessMedicine

Cytomorphometric and Clinical Analysis of the Effects of Azithromycin and Platelet-Rich Fibrin on Wound Healing After Surgical Removal of an Impacted Mandibular Third Molar.

Spasić M, Todorović K, Živković N et al. · 2026 · Journal of functional biomaterials

Impacted mandibular third molars present a common challenge in oral surgery, often associated with postoperative complications such as delayed healing and periodontal defects; therefore, optimizing adjunctive therapies is clinically…

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Negative / Null Result ReportOpen accessMedicine

Translating Evidence into Obstetric Care: Developing a Best Practice-Informed Stepped-Care Clinical Algorithm for the Management of Gestational Insomnia.

Zhao FY, Yue LP, Ho YS et al. · 2026 · Nature and science of sleep

Background and aims Insomnia during pregnancy is potentially associated with adverse outcomes, including gestational diabetes mellitus, pre-eclampsia, cesarean delivery, preterm birth, and depression. This study aimed to synthesize…

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Negative / Null Result ReportMedicine

Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.

Zhou Y, Qin S, Ma Y · 2026 · Clinical and experimental hypertension (New York, N.Y. : 1993)

Background Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with pulsed electrical stimulation at specific…

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Negative / Null Result ReportOpen accessMedicine

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms.

Sun Y, Yang X, Zhu Q et al. · 2026 · Drug design, development and therapy

Autoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current…

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