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Browse the failure-mode index

21,713 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Plasmid diversity, antibiotic resistance and virulence genes associated with Staphylococcus aureus isolates from private hospitals in Gauteng, South Africa.

Ngoie K, Kingsburgh C, Hamiwe T et al. · 2026 · World journal of microbiology & biotechnology

This study investigated the association between plasmid diversity, antibiotic resistance and virulence genes of Staphylococcus aureus (S. aureus) isolates from private hospitals in Gauteng, South Africa. Automated antibiotic susceptibility…

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Negative / Null Result ReportMedicine

Understanding Platelet Activation in the Aeson Bioprosthetic Total Artificial Heart: Insights From Aspirin Treatment and Outcomes.

Smadja DM, Roux de Bezieux J, Peronino C et al. · 2025 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

This study aimed to assess platelet activation following implantation of the Aeson bioprosthetic total artificial heart (A-TAH). We monitored plasma levels of platelet activation markers in patients receiving A-TAH support (n = 16)…

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Negative / Null Result ReportMedicine

Lack of association between Lp(a) and retinal vein occlusion in a single institution and US national database.

Russell MW, Maatouk CM, Kim S et al. · 2024 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Objective This study examines associations between lipoprotein(a) (Lp[a]), a low-density-like lipoprotein, and renal vein occlusion (RVO) in US cohorts to characterize its prognostic role in the setting of RVO. Design A two-phase…

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Negative / Null Result ReportOpen accessMedicine

Single-arm Cohort Study on the Effects of the COVID-19 Pandemic on the Radiation Treatment of Cancer Patients Referred to the Radiation Oncology Division of a Tertiary Hospital.

de Guzman SPC, Chavez LL, Abrilla AA · 2024 · Acta medica Philippina

Objective This study aimed to identify the effects of COVID-19 pandemic on radiation treatment delays, interruptions, and cancer outcomes if any, in a Philippine tertiary hospital. Methods A retrospective observational cohort study was…

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Negative / Null Result ReportOpen accessMedicine

Rurality and Long-Term Outcomes after Critical Illness.

Mart MF, Jones MT, Raman R et al. · 2026 · Annals of the American Thoracic Society

Rationale How rurality may influence recovery after critical illness is unknown. Objectives To examine the association between rurality and disability, cognitive function, and health-related quality of life in ICU survivors and whether it…

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Negative / Null Result ReportOpen accessMedicine

A brief research report of suicide rates in the Brazilian elderly over a 12-year period: the lack of association of the " Setembro Amarelo " campaign for suicide prevention.

Corrêa Matias Pereira C, Najafi Moghaddam Gilani V, Nazif-Munoz JI · 2024 · Frontiers in psychiatry

Objectives Aiming to disseminate information related to suicide prevention in Brazil, the " Setembro Amarelo " campaign has been conducted since 2015. The objective of this study is to assess the association between this campaign and…

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Negative / Null Result ReportOpen accessMedicine

Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.

Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle

Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…

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Negative / Null Result ReportOpen accessMedicine

Outcomes of ACL Reconstruction with Quadriceps Tendon Graft Based on Graft Diameter Relative to Notch Width.

Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine

Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…

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Negative / Null Result ReportMedicine

Plasma omega-3 fatty acids are not associated with muscle strength, regardless of age or protein intake: National Health and Nutrition Examination Survey 2011-12.

Nehme R, Sponchiado IM, Limirio LS et al. · 2025 · Clinical nutrition ESPEN

Background & aims Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive.…

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Negative / Null Result ReportOpen accessMedicine

Genetic Variants in Vitamin-D Metabolism Genes (rs1155563, rs12785878 and rs10500804) among Females with Type-2 Diabetes Mellitus in Saudi Arabia.

Alharazy S · 2024 · Pakistan journal of medical sciences

Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…

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Negative / Null Result ReportOpen accessMedicine

Computationally efficient whole-genome quantile regression at biobank scale.

Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America

Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…

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Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Intraoperative Hypotension and Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A Retrospective Cohort Study.

Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology

Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…

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Negative / Null Result ReportOpen accessMedicine

<i>XPO5</i> Polymorphism in Colon Cancer Patients: A Cross-Sectional Study.

Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences

(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…

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Negative / Null Result ReportMedicine

Comparison of susceptibility of Pseudomonas aeruginosa isolated from keratitis to antibiotics and multipurpose disinfecting solutions.

Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…

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Negative / Null Result ReportMedicine

Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer

Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…

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Negative / Null Result ReportOpen accessMedicine

Peripheral immune system activity in young psychiatry patients.

Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health

The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…

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Negative / Null Result ReportOpen accessMedicine

Implicit Bias and Recognition of Biases Among Vascular Surgeons.

Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research

Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…

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