Negative / Null Result ReportOpen accessNeuroscience
Aaron T. Piepmeier, Jennifer L. Etnier · 2014 · Journal of sport and health science/Journal of Sport and Health Science
The literature shows that improvements in cognitive performance may be observed following an acute bout of exercise. However, evidence in support of the biological mechanisms of this effect is still limited. Findings from both rodent and…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Randi Hjalmarsson, Helena Holmlund, Matthew J. Lindquist · 2014 · The Economic Journal
This article studies the causal effect of educational attainment on conviction and incarceration using Sweden's compulsory schooling reform as an instrument for years of schooling and a 70% sample from Sweden's Multigenerational Register…
View details →Negative / Null Result ReportOpen accessMedicine
Pekka Oja, Paul Kelly, Željko Pedišić et al. · 2016 · British Journal of Sports Medicine
BACKGROUND/AIM: Evidence for the long-term health effects of specific sport disciplines is scarce. Therefore, we examined the associations of six different types of sport/exercise with all-cause and cardiovascular disease (CVD) mortality…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Gracious Diiro, Greg Seymour, Menale Kassie et al. · 2018 · PLoS ONE
This paper documents a positive relationship between maize productivity in western Kenya and women's empowerment in agriculture, measured using indicators derived from the abbreviated version of the Women's Empowerment in Agriculture Index. Applying a cross-sectional instrumental-variable regression method to a data set of 707 maize farm households from western Kenya, we find that women's empowerment in agriculture significantly increases maize productivity. Although all indicators of women's empowerment significantly increase productivity, there is no significant association between the women
View details →Negative / Null Result ReportSocial Sciences
Patrick Sturgis, Ian Brunton‐Smith, Sanna Read et al. · 2010 · British Journal of Political Science
We use a multi-level modelling approach to estimate the effect of ethnic diversity on measures of generalized and strategic trust using data from a new survey in Britain with a sample size approaching 25,000 individuals. In addition to the…
View details →Negative / Null Result ReportOpen accessComputer Science
Michel E. Vandenberghe, Marietta Scott, Paul W. Scorer et al. · 2017 · Scientific Reports
Tissue biomarker scoring by pathologists is central to defining the appropriate therapy for patients with cancer. Yet, inter-pathologist variability in the interpretation of ambiguous cases can affect diagnostic accuracy. Modern artificial intelligence methods such as deep learning have the potential to supplement pathologist expertise to ensure constant diagnostic accuracy. We developed a computational approach based on deep learning that automatically scores HER2, a biomarker that defines patient eligibility for anti-HER2 targeted therapies in breast cancer. In a cohort of 71 breast tumour r
View details →Negative / Null Result ReportOpen accessChemistry
Alice Cheng, Charles E. Grant, William Stafford Noble et al. · 2018 · Bioinformatics
MOTIVATION: Post-translational modifications (PTMs) of proteins are associated with many significant biological functions and can be identified in high throughput using tandem mass spectrometry. Many PTMs are associated with short sequence…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Geert Bekaert, Robert J. Hodrick, Xiaoyan Zhang · 2012 · Journal of Financial and Quantitative Analysis
Abstract We examine aggregate idiosyncratic volatility in 23 developed equity markets, measured using various methodologies. We find no evidence of upward trends after extending the sample to 2008. Instead, idiosyncratic volatility is well…
View details →Negative / Null Result ReportSocial Sciences
Laurie C. Maldonado, Rense Nieuwenhuis · 2015 · Community Work & Family
This study examined to what extent family policies differently affect poverty among single-parent households and two-parent households. We distinguished between reconciliation policies (tested with parental leave and the proportion of…
View details →Negative / Null Result ReportSocial Sciences
T. Ginsburg, Mila Versteeg · 2013 · The Journal of Law Economics and Organization
In recent decades, there has been a wide-ranging global movement towards constitutional review. This development poses important puzzles of political economy: Why would self-interested governments willingly constrain themselves by…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Eva Cecilie Bonefeld‐Jørgensen, Manhai Long, Rossana Bossi et al. · 2011 · Environmental Health
BACKGROUND: Breast cancer (BC) is the most common cancer for women in the western world. From very few cases an extraordinary increase in BC was observed in the Inuit population of Greenland and Canada although still lower than in western populations. Previous data suggest that exposure to persistent organic pollutants (POPs) might contribute to the risk of BC. Rat studies showed that perfluorinated compounds (PFCs) cause significantly increase in mammary fibroadenomas. This study aimed at evaluating the association between serum levels of POPs/PFCs in Greenlandic Inuit BC cases and their cont
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Mirko H. Benischke, Geoffrey Martin, Lotte Glaser · 2018 · Strategic Management Journal
Research Summary We draw upon applied psychology literature to explore interagent differences in perceived risk to their equity when making strategic risk decisions. Our theory suggests behavioral agency's predicted negative relationship between equity risk bearing and strategic risk taking is contingent upon four personality traits. Our empirical analyses, based on personality profiles of 158 Chief Executive Officers (CEOs) of S&P 1,500 firms in manufacturing industries, indicate the relationship between executive risk bearing and strategic risk taking crosses from negative to positive fo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Federico Innocenti, Gregory M. Cooper, Ian B. Stanaway et al. · 2011 · PLoS Genetics
The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina (n = 60) expression arrays and Illumina SNP genotyping (550K), and we also incorporated data from a published study (n = 266). We found that ∼30% of SNP-expression correlations in one study failed to replicate in either of the others, even at thresholds yielding high reproducibility in simulations, and
View details →Negative / Null Result ReportOpen accessComputer Science
Fazle Karim, Somshubra Majumdar, Houshang Darabi · 2019 · IEEE Access
Long short-term memory fully convolutional neural networks (LSTM-FCNs) and Attention LSTM-FCN (ALSTM-FCN) have shown to achieve the state-of-the-art performance on the task of classifying time series signals on the old University of…
View details →Negative / Null Result ReportOpen accessNeuroscience
Megan A. K. Peters, Hakwan Lau · 2015 · eLife
Many believe that humans can 'perceive unconsciously' - that for weak stimuli, briefly presented and masked, above-chance discrimination is possible without awareness. Interestingly, an online survey reveals that most experts in the field recognize the lack of convincing evidence for this phenomenon, and yet they persist in this belief. Using a recently developed bias-free experimental procedure for measuring subjective introspection (confidence), we found no evidence for unconscious perception; participants' behavior matched that of a Bayesian ideal observer, even though the stimuli were visu
View details →Negative / Null Result ReportBusiness, Management and Accounting
Leen Paape, Roland F. Speklé · 2012 · European Accounting Review
We examine (1) the extent of enterprise risk management (ERM) implementation and the factors that are associated with cross-sectional differences in the level of ERM adoption, and (2) specific risk management design choices and their…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Charles L. Steinhardt, Joshua S. Speagle, P. Capak et al. · 2014 · The Astrophysical Journal Letters
Using the first 50% of data collected for the Spitzer Large Area Survey with Hyper-Suprime-Cam observations on the 1.8 deg^2 Cosmological Evolution Survey we estimate the masses and star formation rates of 3398 M_* > 10^(10) M_☉…
View details →Negative / Null Result ReportSocial Sciences
Michael A. Beam, Myiah J. Hutchens, Jay D. Hmielowski · 2018 · Information Communication & Society
The rise of social media, and specifically Facebook, as a dominant force in the flow of news in the United States has led to concern that people incur greater isolation from diverse perspectives through filter bubbles (from algorithmic…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nathalie Seddon, Carlos A. Botero, Joseph A. Tobias et al. · 2013 · Proceedings of the Royal Society B Biological Sciences
Sexual selection is proposed to be an important driver of diversification in animal systems, yet previous tests of this hypothesis have produced mixed results and the mechanisms involved remain unclear. Here, we use a novel phylogenetic approach to assess the influence of sexual selection on patterns of evolutionary change during 84 recent speciation events across 23 passerine bird families. We show that elevated levels of sexual selection are associated with more rapid phenotypic divergence between related lineages, and that this effect is restricted to male plumage traits proposed to functio
View details →Negative / Null Result ReportOpen accessMedicine
Christoph Garbers, Wolfgang Thaiss, Gareth W. Jones et al. · 2011 · Journal of Biological Chemistry
IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most pathophysiological conditions are characterized by a molar excess of serum sIL-6R over IL-6 characterized by free IL-6 and IL-6 found in IL-6·sIL-6R complexes allowing both classic and trans-signaling. Surprisingly, under these conditions, sgp130 was able to trap all free IL-6 molecules in IL-6·sIL-6R·sg
View details →Negative / Null Result ReportOpen accessMedicine
Joshua S. Bingham, Henry D. Clarke, Mark J. Spangehl et al. · 2014 · Clinical Orthopaedics and Related Research
BACKGROUND: Diagnosing a periprosthetic joint infection (PJI) requires a complex approach using various laboratory and clinical criteria. A novel approach to diagnosing these infections uses synovial fluid biomarkers. Alpha defensin-1…
View details →Negative / Null Result ReportOpen accessMedicine
US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2018 · JAMA
Importance: Cardiovascular disease (CVD) is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk Score, the Pooled Cohort Equations, or similar CVD risk assessment models. If current CVD risk assessment models could be improved by adding more risk factors, treatment might be better targeted, thereby maximizing the benefits and minimizing the harms. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on using nontraditional risk factors in coron
View details →Negative / Null Result ReportOpen accessMedicine
Basil T. Darras, Thomas O. Crawford, Richard S. Finkel et al. · 2019 · Annals of Clinical and Translational Neurology
Abstract Objective To evaluate plasma phosphorylated neurofilament heavy chain ( pNF ‐H) as a biomarker in spinal muscular atrophy ( SMA ). Methods Levels of pNF ‐H were measured using the ProteinSimple ® platform in plasma samples from…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Stephen M. Pawson, Martin Karl‐Friedrich Bader · 2014 · Ecological Applications
Recognition of the extent and magnitude of night-time light pollution impacts on natural ecosystems is increasing, with pervasive effects observed in both nocturnal and diurnal species. Municipal and industrial lighting is on the cusp of a…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Hami Amiraslani, Karl V. Lins, Henri Servaes et al. · 2022 · Review of Accounting Studies
Abstract We investigate whether a firm’s social capital and the trust that it engenders are viewed favorably by bondholders. Using firms’ environmental and social (E&S) performance to proxy for social capital, we find no relation between social capital and bond spreads over the period 2006–2019. However, during the 2008–2009 financial crisis, which represents a shock to trust and default risk, high-social-capital firms benefited from lower bond spreads. These effects are stronger for firms with higher expected agency costs of debt and firms whose E&S efforts are more salient. During th
View details →Negative / Null Result ReportOpen accessMedicine
James J. McNamee, Michael Gillies, Nicholas Barrett et al. · 2021 · JAMA
Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. Objective: To determine…
View details →Negative / Null Result ReportOpen accessMedicine
Catherine Limperopoulos, Gevorg Chilingaryan, Nancy Sullivan et al. · 2012 · Cerebral Cortex
Cerebellar injury is an important complication of preterm birth with far-reaching neuropsychiatric sequelae. We have previously shown a significant association between isolated injury to the premature cerebellum and subsequent impairment…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ronald E. Robertson, Shan Jiang, Kenneth Joseph et al. · 2018 · Proceedings of the ACM on Human-Computer Interaction
There is a growing consensus that online platforms have a systematic influence on the democratic process. However, research beyond social media is limited. In this paper, we report the results of a mixed-methods algorithm audit of partisan…
View details →Negative / Null Result ReportDentistry
Stefan Roehling, Monika Astasov‐Frauenhoffer, Irmgard Hauser‐Gerspach et al. · 2016 · Journal of Periodontology
Background: It has been hypothesized that zirconia might have a reduced bacterial adhesion compared with titanium; however, results from experimental studies are rather controversial. The aim of the present study is to compare biofilm…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Taraka Davies‐Barnard, Pierre Friedlingstein · 2020 · Global Biogeochemical Cycles
Abstract Biological nitrogen fixation is a key contributor to sustaining the terrestrial carbon cycle, providing nitrogen input that plants require. However, the amount and global distribution of this fixation is highly disputed. Using a…
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