Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response
Eric Ubil; Laura S. Caskey; Alisha Holtzhausen; Debra M. Hunter; Charlotte Story; H. Shelton Earp · 2018 · Journal of Clinical Investigation
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract (excerpt)
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In…
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Metadata source: OpenAlex · DOI 10.1172/jci97354