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Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Absence of osteoclastogenic response to pooled polyclonal anti-citrullinated peptide/protein antibodies from patients with rheumatoid arthritis in vitro.

Chen X, An Z, Li C et al. · 2026 · Clinical and experimental medicine

Anti-citrullinated peptide/protein antibodies (ACPAs) are specific serological markers for rheumatoid arthritis (RA), but their direct role in promoting osteoclastogenesis remains controversial. This study aims to determine whether…

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Negative / Null Result ReportMedicine

A Retrospective Study of Outcome Predictive Models for Anterior Circulation Stroke Post Endovascular Thrombectomy: Are CT-Derived Morphomics Useful?

Manole C, Shet S, O Apos Brien A et al. · 2026 · Cerebrovascular diseases extra

Introduction In acute ischaemic stroke secondary to a large vessel occlusion, endovascular thrombectomy (EVT) is the standard of care. However, prediction of functional outcomes following EVT remains challenging. We sought to determine…

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Negative / Null Result ReportMedicine

CT-confirmed union rates following ankle and hindfoot arthrodesis with and without biological augmentation: A retrospective series.

Matheron G, Pearse R, Dellis S et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

Background Nonunion remains a major complication after ankle and hindfoot arthrodesis. Biologic augmentation is frequently used to mitigate this risk, but incremental benefit remains unproven. This study evaluated CT-verified union rates…

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Negative / Null Result Report

Evaluating eDNA Detection from Live and Dead Control Sources

Blankenship SM, Dean C, Karpenko K et al. · 2026 · Preprint

Environmental DNA (eDNA) methods offer a powerful tool for monitoring aquatic species, yet field applications remain challenged by uncertainty in DNA transport, mixing, and detection, particularly in flowing or tidally influenced systems.…

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Negative / Null Result ReportOpen accessMedicine

Effect of Phantom Containing Implants Angulation on the Amount of Metal Artifacts Around the Implants in CBCT Images.

Valizadeh S, Moshfeghi M, Bahrani Z et al. · 2026 · International journal of dentistry

Objective Artifacts from dental implants impact the clarity of cone-beam computed tomography (CBCT) scans, posing challenges to radiographic detection in adjacent areas. The aim of this in vitro study is to examine the effect of angling a…

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Negative / Null Result ReportMedicine

Monocyte-Containing Inflammatory Indices Show Stronger Association with 30-Day Mortality than the Systemic Immune-Inflammation Index in Elderly Sepsis: A Single-Center Retrospective Observational Cohort Study.

Irimie AI, Dinescu SN, Novac MB et al. · 2026 · Journal of clinical medicine

Background . Hematological inflammatory indices from the complete blood count have been proposed as inexpensive prognostic markers in sepsis. The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are the…

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Negative / Null Result ReportMedicine

Postoperative duloxetine administration did not significantly modify overall pain trajectories following high tibial osteotomy: An open-label randomized controlled trial.

Sengoku M, Ogawa H, Nakamura Y et al. · 2026 · Journal of orthopaedic surgery (Hong Kong)

BackgroundDuloxetine is a potent analgesic that reduces pain associated with knee osteoarthritis. This study aimed to evaluate the analgesic effects of regular postoperative duloxetine after high tibial osteotomy (HTO) and its influence on…

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Negative / Null Result ReportMedicine

Impact of resistant starch from high amylose wheat compared to inulin on human gut microbiota and host immune responses using an artificial colon associated to human leukocytes.

Couturier I, Denis S, Rossary A et al. · 2026 · Food chemistry

Cooked High Amylose Wheat (HAW) products are dietary sources of resistant starch (RS). While its effects on gut microbiota are known, links to immune responses remain unclear. This study evaluated the antioxidant and anti-inflammatory…

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Negative / Null Result ReportMedicine

The impacts of public hospital compensation reform on the health workforce compensation and its structure: quasi-experimental evidence in China.

Zhao Y, Peng Z, Cao D et al. · 2026 · BMC health services research

Background The Chinese government piloted the public hospital's compensation system reform in 2017. It is important for policymakers to understand how this reform has affected the health workforce's compensation and its structure. We…

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Negative / Null Result ReportMedicine

The renin angiotensin system in cognitive flexibility: Effects of single-dose losartan on task-switching in healthy volunteers.

Prasad D, Feltham G, De Giorgi R et al. · 2026 · Journal of psychopharmacology (Oxford, England)

Introduction Cognitive flexibility, defined as the ability to shift mental strategies when environmental demands change, may influence psychological well-being and psychiatric treatment outcomes. Research increasingly implicates the renin…

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Negative / Null Result ReportMedicine

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb-Drug Interaction Investigation.

Gajula SNR, Kallam JS, Kanukolanu A et al. · 2026 · Biopharmaceutics & drug disposition

Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the…

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Negative / Null Result Report

Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice

Liu W, Tang Y, Ding W et al. · 2026 · Preprint

Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances. Ergothioneine (EGT) is a diet-derived thiol/thione antioxidant, yet its effects on the…

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Negative / Null Result ReportMedicine

Short-term intraocular pressure changes following intravitreal aflibercept 8 mg versus 2 mg in diabetic macular edema: a prospective observational study.

Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports

This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…

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Negative / Null Result ReportMedicine

The impact of the vaginal birth after cesarean as a new delivery mode on quality of life, sexual function, sleep quality and urinary incontinence during the postpartum period and comparison with the results of vaginal birth and cesarean delivery.

Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…

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Negative / Null Result ReportMedicine

Comprehensive assessment of hyperoside: cytotoxic, anti-cancer, genoprotective, radical scavenging and computational toxicity properties through <i>in vitro</i> and <i>in silico</i> approaches.

Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods

Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…

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