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Browse the failure-mode index

21,710 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

When pooling fails: low-intensity <i>Angiostrongylus cantonensis</i> infections in <i>Theba pisana</i> result in false-negativity.

Anettová L, Jaume-Ramis S, Paredes-Esquivel C et al. · 2026 · Journal of helminthology

Pooling of gastropod samples is frequently used in surveys of the neurotropic nematode Angiostrongylus cantonensis to reduce cost and processing time. Here we highlight a potential limitation of this technique using the snail Theba pisana…

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Negative / Null Result ReportMedicine

DNA metabarcoding for food authentication: identification of freshwater, marine, and terrestrial gastropods in commercial food products.

Andronache J, Cichna-Markl M, Dobrovolny S et al. · 2026 · NPJ science of food

Food fraud through species substitution has been reported for edible gastropods, particularly in processed products where morphological identification is not feasible. DNA-based methods have been used to identify gastropod species in food…

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Negative / Null Result ReportOpen accessMedicine

Reality check: testing the <i>in silico</i> predictions of false negative results due to mutations in SARS-CoV-2 PCR assays using templates with mismatches <i>in vitro</i>.

Otwell T, Knight B, Coryell M et al. · 2025 · Frontiers in cellular and infection microbiology

Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care…

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Negative / Null Result ReportMedicine

Diagnostic performance of somatostatin receptor positron emission tomography in preoperative evaluation of pancreatic neuroendocrine tumor lymph node metastases.

Gudmundsdottir H, Hernandez-Delima FJ, McDowell BC et al. · 2026 · Surgery

Background Regional lymph node involvement impacts prognosis for patients with pancreatic neuroendocrine tumors and may influence management decisions for small tumors. Conventional cross-sectional imaging modalities have low sensitivity…

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Negative / Null Result ReportOpen accessMedicine

Endogenous Biomarkers Analysis and False-Negative Results for SARSCov2 Using two Commercial RT-PCR Diagnostic Kits.

Khoshakhlagh M, Dehghani T, Alizadeh A et al. · 2026 · Iranian journal of pathology

Background & objective Real-time PCR is widely used to detect SARS-CoV-2, the virus responsible for COVID-19, but false-negative results can occur even with internal controls. This study aimed to investigate the impact of using alternative…

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Negative / Null Result ReportOpen accessMedicine

False-negative results of combined endobronchial and endoscopic ultrasound in mediastinal staging of lung cancer.

Gambuś K, Moszczyński K, Popovchenko S et al. · 2026 · Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

Introduction Accurate assessment of mediastinal lymph node involvement is crucial for treatment planning in lung cancer. Combined endobronchial and endoscopic ultrasound (CUS) offers high sensitivity and negative predictive value (NPV),…

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Negative / Null Result ReportMedicine

Influence of Ongoing Antibiotic Therapy on the Detection of Pathogenic Microorganisms Using Metagenomic Next-Generation Sequencing and Blood Culture in ICU Patients.

Schroeder TH, Eliwi Alsaffan M, Stäudle H et al. · 2026 · Journal of clinical medicine

Background: Blood cultures often yield negative results in critically ill patients, particularly after antimicrobial therapy has started. Plasma metagenomic next-generation sequencing enables culture-independent pathogen detection, but its…

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Negative / Null Result ReportMedicine

Butyrate in ulcerative colitis and pouchitis: friend or foe?

Rhodes JM · 2026 · The British journal of nutrition

It is widely known that the short chain fatty acid (SFA) butyrate, generated mainly through fermentation of dietary fibre by anaerobic bacteria, has beneficial effects on health. Less widely known is that butyrate, at the concentration…

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Negative / Null Result ReportOpen accessMedicine

Impact of Blood Herpes Simplex Virus Polymerase Chain Reaction Testing in Neonatal Management of Herpes Simplex Virus Infection: An Institutional Experience.

Alvarez AM, Vega M, Valencia-Shelton F et al. · 2026 · Cureus

Background The evaluation of neonatal herpes simplex virus (HSV) includes HSV culture and/or polymerase chain reaction (PCR) of different surfaces, cerebrospinal fluid (CSF), and blood. However, the impact of blood HSV PCR for the…

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Negative / Null Result Report

Anterior middle cingulate cortex gamma-aminobutyric acid level is elevated in children with both familial and prenatal alcohol exposure-associated attention deficit hyperactivity disorder

Alger JR, Gupta I, Farkouh L et al. · 2026 · Preprint

Background Prior neuroimaging suggests brain differences between children with attention deficit hyperactivity disorder due to prenatal alcohol exposure (ADHD+PAE) and non-exposed children with ADHD due to other, e.g., familial, causes…

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