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Browse the failure-mode index

21,707 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

When coverage is high: rethinking the role of caregiver perceptions in childhood vaccination uptake in Uganda.

Gunderson AK, Kwon T, Kumarasinghe Y et al. · 2026 · Transactions of the Royal Society of Tropical Medicine and Hygiene

Background Beliefs of a child's primary caregiver are known to influence immunization uptake. As coverage increases, the characteristics of households with undervaccinated children may be shifting. Methods We conducted a cross-sectional…

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Negative / Null Result ReportMedicine

ESR1 as a candidate gene for adolescent idiopathic scoliosis pathogenesis in North-West Indian population.

Kowra S, Singh H, Singh V et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Introduction Estrogens are crucial in the development and growth of skeletal systems. Estrogen receptor alpha (ESRα) and beta (ESRβ) are crucial regulators of estrogen response. Estrogen receptor genes (ESR1 and ESR2) have been extensively…

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Negative / Null Result ReportMedicine

Mediterranean diet and MIND diet adherence in relation to biochemical markers in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A cross-sectional study.

Acar Ozer T, Arslan M, Şahin K · 2026 · Nutrition and health

BackgroundMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is one of the most prevalent chronic liver diseases worldwide and is strongly associated with metabolic dysfunction. Dietary patterns such as the Mediterranean and…

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Negative / Null Result ReportMedicine

Oral Manifestations in a Drug-Addicted Population Being Treated in Rehabilitation Clinics in Northern Portugal: A Cross-Sectional Observational Study.

Moreira A, Azevedo R, Costa JA et al. · 2026 · European journal of dentistry

Objective Drug addiction is a growing global health concern with significant oral health consequences. Cannabis and cocaine are among the most frequently used illicit drugs, contributing to a high burden of oral pathologies. This study…

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Negative / Null Result ReportMedicine

Problematic social media use, mental health, and substance use in Czech adolescents: the comparative role of extracurricular activities - findings from the 2022 HBSC study.

Helvich J, Machu V, Novak L et al. · 2026 · Archives of public health = Archives belges de sante publique

Background Problematic social media use (PSMU) has become a critical public health concern. However, little is known about how the associations between PSMU, mental health, and substance use differ depending on participation in distinct…

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Negative / Null Result ReportMedicine

Effect of Concurrent Anti-Seizure Medications on the Efficacy of the Ketogenic Diet in Children with Epilepsy.

Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…

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Failed Experiment ReportMedicine

Association of prior beta-blocker treatment and outcome in patients with out-of-hospital cardiac arrest.

Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society

Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…

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Negative / Null Result ReportMedicine

Clinical Outcomes in Japanese Patients with Chronic Limb Threatening Ischaemia Undergoing Tibial and Pedal Bypass with a Single Segment Great Saphenous Vein Graft.

Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…

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Failed Experiment ReportMedicine

Improved Iron Status, but Not Protein Source, Is Related to Appetite, Satiety, and Mood in Women of Reproductive Age With Iron Deficiency: A Randomized Controlled Trial.

Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition

Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…

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