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Browse the failure-mode index

21,707 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Effectiveness of chlorhexidine gluconate-impregnated dressings in preventing central line-associated bloodstream infection in a paediatric intensive care unit: A randomised controlled trial.

Portero-Prados FJ, Pabón-Carrasco M, Ponce-Blandón JA · 2026 · Intensive & critical care nursing

Objectives To compare the effectiveness and dermatological safety of chlorhexidine gluconate (CHG)-impregnated dressings versus conventional transparent dressings in preventing central line-associated bloodstream infection (CLABSI) in…

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Negative / Null Result ReportMedicine

Associations of preoperative patient mental health status, sociodemographic and clinical characteristics with baseline pain, function and satisfaction in patients undergoing revision rotator cuff repairs.

Streubel PN, Sahoo S, Zhang C et al. · 2026 · Journal of shoulder and elbow surgery

Background This study aimed to investigate the associations of general patient and disease-specific factors with baseline patient reported outcome measures (PROMs) in patients undergoing revision rotator cuff repair (RCR). Baseline…

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Negative / Null Result ReportMedicine

Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.

McGranahan MJ, Sabino-Carvalho JL, Zanuzzi MG et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Individuals with posttraumatic stress disorder (PTSD) are at elevated risk for cardiovascular disease (CVD). Emerging research suggests that increased blood pressure variability (BPV) reflects abnormalities in autonomic regulation and may…

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Negative / Null Result ReportMedicine

Risk Factors for Recurrence and Complications Following Cytoreductive Surgery in Platinum-Resistant Ovarian Cancer: A Retrospective Cohort Study.

Wang L, Yao L, Wan J et al. · 2026 · Annali italiani di chirurgia

Aim This study aims to identify independent risk factors for tumor recurrence and postoperative complications in platinum-resistant ovarian cancer patients undergoing cytoreductive surgery. Methods This study retrospectively included 96…

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Negative / Null Result ReportOpen accessMedicine

Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.

Eruysal E, Ravdin L, Iadecola C et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundResistin is a circulating protein linked to systemic metabolic disorders and inflammation, both of which can contribute to the pathogenesis of Alzheimer's disease (AD). However, the role of resistin during the preclinical stage…

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Negative / Null Result ReportOpen accessMedicine

Subcutaneous Tranexamic Acid Achieves Comparable Serum Concentrations to Intramuscular Administration During Haemorrhagic Shock in a Swine Model.

Lynghaug T, Fuskevåg OM, Storm BS et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Tranexamic acid is an antifibrinolytic agent reducing mortality when administered to trauma patients with haemorrhagic shock. This mortality reduction is time sensitive. Increased intramuscular dose administration has proven an…

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Negative / Null Result ReportOpen accessMedicine

Impact of tumor budding on recurrence risk prediction in stage I-III colorectal cancer: a Swedish cohort study.

Barot S, Andersson-Franko M, Ghazi S et al. · 2026 · American journal of clinical pathology

Objectives Tumor budding is an emerging micromorphologic predictor of recurrence in localized colorectal cancer (CRC). Whether its addition to established CRC recurrence risk factors routinely assessed in clinical practice improves…

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Negative / Null Result ReportMedicine

Feasibility of Individualized Homoeopathic Treatment in Temporomandibular Joint Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial.

Bhattacharjee B, Ghosh S, Basu N et al. · 2026 · Journal of integrative and complementary medicine

Objectives To assess the feasibility of conducting a randomized controlled trial and to explore preliminary effects of individualized homoeopathic medicines (IHMs) compared with placebo in patients with temporomandibular joint dysfunction…

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Negative / Null Result Report

The Inflation Reduction Act’s Impact Upon Late-Stage R&D

Bowen HP, O’Loughlin G, Schleicher C et al. · 2026 · Preprint

Background The impact of the Inflation Reduction Act (IRA) upon late-stage developments has been assumed to be limited. The Congressional Budget Office’s IRA analysis excluded post-approval innovation, potentially overlooking substantial…

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Negative / Null Result ReportMedicine

Association between short-term air pollution exposure and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke: a time-stratified case-crossover study.

Gu X, Liu J, Wang H et al. · 2026 · Frontiers in public health

Objective To analyze the association between short-term exposure to air pollutants and the risk of fatal recurrence within 1 year in patients with first-episode acute hemorrhagic stroke, to provide scientific basis for health management…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Clinical Outcomes of INBONE II Total Ankle Arthroplasty in Patients Under 50 and Over 65 Years: A 4-Year Retrospective Study.

Xu X, Zhang B, Wang X et al. · 2026 · Orthopaedic surgery

Objective There is no consensus on the age restriction for total ankle arthroplasty (TAA) patients. The aim of our study was to analyze the clinical function, radiographic outcomes, patient satisfaction, and complications between patients…

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Negative / Null Result ReportOpen accessMedicine

An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial.

Lopresti AL, Smith SJ, Ferdinands FR · 2026 · Frontiers in reproductive health

Background Khaya senegalensis is a tree species that has traditional use for the alleviation of menstrual and hormonal symptoms in women. Moreover, supplementation with a Khaya senegalensis preparation (Khapregesic®) was associated with…

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Negative / Null Result ReportOpen accessMedicine

Short-Term Gingival Microcirculatory Responses to Non-Invasive Physical Stimulation: Implications for Accelerated Orthodontic Research.

Atsuta S, Koizumi S, Takahashi SS et al. · 2026 · Dentistry journal

Background/Objectives : Acceleration of orthodontic tooth movement remains a major challenge in clinical orthodontics. Evidence suggests that increased local blood flow around the alveolar bone is key to bone remodeling and potentially…

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Replication FailureOpen accessMedicine

Management of Distal Radius Fractures in Frail Elderly Patients With High Anesthetic Risk: Cast Immobilization Versus Volar Locking Plate Fixation.

Yiğit N, Nazlıgül AS, Ülgen NK et al. · 2026 · Geriatric orthopaedic surgery & rehabilitation

Background Distal radius fractures are common among elderly patients and frequently pose management challenges due to advanced age, multiple comorbidities, and increased anesthesia-related risks. In high-risk individuals with limited…

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