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Browse the failure-mode index

21,697 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Earlier first-time memory clinic visits during the COVID-19 pandemic: A comparison of dementia severity and caregiver burden.

Maeda A, Suzuki M, Suzumura S et al. · 2026 · Journal of family medicine and primary care

Introduction The coronavirus disease 2019 pandemic prompted widespread restrictions on daily activities, leading to concerns over delayed medical consultations. However, limited social interaction outside the home may have increased the…

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Negative / Null Result ReportMedicine

Skittering locomotion in cricket frogs: a form of porpoising.

Weiss T, Gillis GB, Van Mullekom J et al. · 2024 · The Journal of experimental biology

Multiple species of frogs in the Ranidae family have been observed to 'skitter' across the water surface, but little is understood about the biomechanical or physical mechanisms that underlie this behavior. All documented descriptions are…

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Negative / Null Result ReportOpen accessMedicine

Mentalizing on the edge: borderline traits and their association with real-time self-reflection - an ecological momentary assessment study.

Höller I, Schwitzky S, Forkmann T et al. · 2026 · Borderline personality disorder and emotion dysregulation

Background Mentalization plays a key role in borderline personality disorder (BPD), yet its moment-to-moment fluctuations remain understudied. This study is the first to use established self-report items within an Ecological Momentary…

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Negative / Null Result ReportMedicine

Nanopatterns on silica scales of Mallomonas (Chrysophyceae, Stramenopiles): Unraveling UV resistance potential and diverse response to UVA and UVB radiation

Němcová Y, Knotek P, Jadrná I et al. · 2024 · Journal of phycology

Mallomonas thrive primarily in freshwaters and dominate plankton communities, especially in oligotrophic waters. The cells have a siliceous cell covering of regularly arranged scales. Despite their ecological importance, the intricate…

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Negative / Null Result ReportMedicine

Exposure to structural racism-related state laws is associated with worse cardiovascular health among US adults, BRFSS 2011 and 2013.

Needham BL, Dokshina D, Ali T et al. · 2025 · American journal of epidemiology

The objective of this study was to determine whether exposure to structural racism-related state laws is associated with cardiovascular health among a racially and ethnically diverse sample of US adults. Data were from the Database of…

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Negative / Null Result ReportMedicine

Expression of CD226 on γδ T cells is lower in advanced chronic lymphocytic leukemia and correlates with IgA, IgG and LDH levels.

Zarobkiewicz MK, Lehman N, Kowalska W et al. · 2025 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Gamma-delta (γδ) T cells comprise an important subset of human T cells, responding to viral and bacterial infections, and are significant for cancer immunosurveillance. Human γδ T cells are divided into 5 major subsets, namely…

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Negative / Null Result ReportMedicine

Exploring fonts as retrieval cues in text-based learning.

Krieglstein F, Jansen S, Meusel F et al. · 2024 · Acta psychologica

A growing body of research focuses on optimizing retrieval processes to help learners recall information from memory. The context-dependent memory effect suggests that information retrieval is more effective when the retrieval context…

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Negative / Null Result ReportOpen accessMedicine

Combining Endoscopic Submucosa Dissection and Endoscopic Full-Thickness Resection for Resection of a Gastric Schwannoma Mimicking Gastrointestinal Stroma Tumor.

Kormann S, Semadeni GM, Weber M et al. · 2024 · ACG case reports journal

Subepithelial gastric tumors are a diagnostic challenge. Endoscopic ultrasound allows differentiation. Lesions originating from the submucosal layer can be resected using endoscopic submucosal dissection (ESD). Surgery or endoscopic…

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Negative / Null Result ReportMedicine

Multi-parametric magnetic resonance imaging of the prostate in Victoria, Australia; unintended consequences of changing Medicare Benefits Schedule access.

Gordon P, Urquhart E, Oad S et al. · 2024 · Australian health review : a publication of the Australian Hospital Association

Objective To assess whether prostate biopsy rates have altered with the July 2018 change in Australian Medicare Benefits Schedule (MBS) rebates supporting multiparametric magnetic resonance imaging (mpMRI) for diagnosing prostate cancer.…

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Negative / Null Result ReportOpen accessMedicine

A Case of Unexpected Peritoneal Carcinomatosis From Colon Cancer Detected After Robot-Assisted Radical Cystectomy for Advanced Bladder Cancer.

Ito K, Yamashita R, Kasai S et al. · 2026 · IJU case reports

Introduction Peritoneal carcinomatosis in patients with advanced bladder cancer is a rare but lethal event following robot-assisted radical cystectomy (RARC). We report a case of an unusual clinical course in which peritoneal dissemination…

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Negative / Null Result ReportMedicine

Integrating vision and somatosensation does not improve the accuracy and response time when estimating area and perimeter of rectangles in primary school.

Leukel C, Loibl K, Leuders T · 2024 · Trends in neuroscience and education

Background Problem-solving and learning in mathematics involves sensory perception and processing. Multisensory integration may contribute by enhancing sensory estimates. This study aims to assess if combining visual and somatosensory…

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Negative / Null Result ReportMedicine

Efficacy and safety of rilzabrutinib in patients with moderate-to-severe atopic dermatitis: 16-week results from a proof-of-concept phase II clinical trial.

Kircik L, Tsianakas A, Valenzuela F et al. · 2025 · The British journal of dermatology

Background Atopic dermatitis (AD), the most common inflammatory skin disorder, carries a significant public health burden. Many patients with moderate-to-severe AD are unable to achieve adequate disease control with topical treatment and…

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Negative / Null Result ReportMedicine

ALBAN (GETUG-AFU 37): a phase III, randomized, open-label international trial of intravenous atezolizumab and intravesical Bacillus Calmette-Guérin (BCG) versus BCG alone in BCG-naive high-risk, non-muscle-invasive bladder cancer (NMIBC).

Roupret M, Bertaut A, Pignot G et al. · 2026 · Annals of oncology : official journal of the European Society for Medical Oncology

Background Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…

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Negative / Null Result ReportMedicine

Phase II Trial of Ponatinib in Patients with Metastatic Gastrointestinal Stromal Tumor following Failure or Intolerance of Prior Therapy with Imatinib (POETIG Trial).

Falkenhorst J, Ivanyi P, Schulz T et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Imatinib resistance is conferred by secondary mutations within the ATP-binding pocket or the activation loop of KIT in gastrointestinal stromal tumors (GIST). Ponatinib is active against KIT secondary activation loop and the…

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Negative / Null Result ReportOpen accessMedicine

A phase II study of trifluridine/tipiracil in combination with ramucirumab in advanced, refractory gastric, or gastroesophageal junction adenocarcinomas.

Kim DW, Kim RD, Jimenez MM et al. · 2025 · The oncologist

Background Ramucirumab plus paclitaxel after progression on fluoropyrimidine/platinum in metastatic gastric (GA) and gastroesophageal junction adenocarcinoma (GEJC) has shown improvement in overall survival over paclitaxel alone. However,…

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Negative / Null Result ReportOpen accessMedicine

Effect of Adjuvant Silodosin on Stone Clearance After Extracorporeal Shock Wave Lithotripsy for Renal Stones: A Randomised Controlled Trial.

Leelahawong P, Ketsuwan C · 2026 · Journal of clinical medicine

Background/Objectives : To evaluate whether adjunctive silodosin improves the stone-free rate (SFR) and clinical outcomes of extracorporeal shock wave lithotripsy (ESWL) for renal calculi. Methods : In this prospective randomised…

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Negative / Null Result ReportOpen accessMedicine

STRATEGIC-1: multiple-line, randomized, open-label GERCOR-PRODIGE-39 phase III trial in unresectable RAS/BRAF wild-type metastatic colorectal cancer.

Chibaudel B, Dourthe LM, André T et al. · 2026 · Signal transduction and targeted therapy

Managing unresectable metastatic colorectal cancer (mCRC) requires a comprehensive strategy. While chemotherapy, anti-angiogenic, and anti-epidermal growth factor receptor (EGFR) agents are available, strategy trials are needed to optimize…

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