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WASTE Journal

Browse the failure-mode index

21,697 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effect of acute kidney injury and overall survival in patients with postoperative head and neck cancer who received chemoradiotherapy with cisplatin: A supplementary analysis of the phase II/III trial of JCOG1008.

Imamura Y, Kiyota N, Tahara M et al. · 2024 · Cancer medicine

Background In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m 2 ) was non-inferior to 3-weekly cisplatin (100 mg/m 2 ) for postoperative high-risk head and neck cancer. We investigated how acute kidney injury (AKI), a…

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Negative / Null Result ReportOpen accessMedicine

No association between chronotype and cardiovascular response to a cognitive challenge in the morning using a Bayesian approach.

Wüst LN, Cajochen C, Lasauskaite R · 2025 · Neurobiology of sleep and circadian rhythms

A chronotype is defined as a preference for certain behaviours (e.g., sleep and wake) to occur at specific times of day. It is therefore also temporally linked with cognitive performance across the day. In an exploratory analysis, we…

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Negative / Null Result ReportOpen accessMedicine

Effect of different doses of gadolinium contrast agent on clinical outcomes in MS.

Ackermans N, Taylor C, Tam R et al. · 2019 · Multiple sclerosis journal - experimental, translational and clinical

Objective The objective of this paper is to evaluate potential dose-dependent adverse effects of gadolinium-based contrast agents (GBCAs) on MS progression. Methods Outcomes from a cohort of 612 secondary progressive MS (SPMS) patients,…

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Negative / Null Result ReportMedicine

Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus.

Chamberlain DB, Chamberlain JM · 2017 · Annals of emergency medicine

Study objective We demonstrate the application of a Bayesian approach to a recent negative clinical trial result. A Bayesian analysis of such a trial can provide a more useful interpretation of results and can incorporate previous…

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Negative / Null Result ReportOpen accessMedicine

Fluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer-A Pilot Study.

Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine

(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…

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Negative / Null Result ReportOpen accessMedicine

Determining the Effectiveness of Fibrin Sealants in Reducing Complications in Patients Undergoing Lateral Neck Dissection (DEFeND): A Randomised External Pilot Trial.

Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers

Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…

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Replication FailureOpen accessMedicine

Intensivists at night: putting resources in the right place.

Levy MM · 2013 · Critical care (London, England)

During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small…

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Negative / Null Result ReportMedicine

Odds and ends in psychopharmacology from the past 10 years.

Howland RH · 2015 · Journal of psychosocial nursing and mental health services

Seven topics previously described in this column are revisited. The use of quantitative electroencephalography has been shown in a prospective study to be effective for predicting antidepressant treatment response. A novel antidepressant…

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Failed Experiment ReportMedicine

Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib.

Saraceni F, Scortechini I, Mancini G et al. · 2021 · Transplant infectious disease : an official journal of the Transplantation Society

Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in…

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Replication FailureOpen accessMedicine

Regional nodal irradiation (RNI) in breast cancer patients with residual isolated tumor cells or micrometastatic nodal disease after neoadjuvant chemotherapy.

Kim JK, Karp JM, Gerber NK · 2023 · Clinical and translational radiation oncology

Background/purpose The optimal management of residual micrometastases and isolated tumor cells (ITC) in patients with invasive breast cancer who undergo neoadjuvant chemotherapy (NAC) followed by definitive surgery is not well-studied. We…

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Negative / Null Result ReportOpen accessMedicine

Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial.

Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open

Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…

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Negative / Null Result ReportOpen accessMedicine

Metabotropic Glutamate Receptor 4 (mGlu4) Positive Allosteric Modulators Lack Efficacy in Rat and Marmoset Models of L-DOPA-Induced Dyskinesia.

Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease

Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…

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Negative / Null Result ReportOpen accessMedicine

The effect of negative randomized trials and surgeon volume on the rates of arthroscopy for patients with knee OA.

Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications

Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of Wharton Jelly Mesenchymal Stromal Cells infusions in moderate to severe SARS-Cov-2 related acute respiratory distress syndrome: a phase 2a double-blind randomized controlled trial.

Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine

Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…

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Negative / Null Result ReportOpen accessMedicine

Exhaled-Breath Testing Using an Electronic Nose during Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome: An Experimental Pilot Study.

Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine

The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…

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Negative / Null Result ReportOpen accessMedicine

Radiation Therapy for Retroperitoneal Sarcomas: A Strass-Ful Situation.

Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)

Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…

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Negative / Null Result ReportOpen accessMedicine

Pembrolizumab Plus Docetaxel Versus Docetaxel for Previously Treated Metastatic Castration-Resistant Prostate Cancer: The Randomized, Double-Blind, Phase III KEYNOTE-921 Trial.

Petrylak DP, Ratta R, Matsubara N et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose The standard of care for metastatic castration-resistant prostate cancer (mCRPC) after second-generation androgen receptor pathway inhibitor (ARPI) therapy is still docetaxel. The randomized, double-blind, phase III KEYNOTE-921…

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