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Browse the failure-mode index

21,253 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A Randomized, Double-Blind, Pilot Study of N-Acetylcysteine for Motor and Cognitive Symptoms in Youth With Neurofibromatosis Type 1.

Gilbert DL, Aschbacher-Smith LE, Migneault KY et al. · 2026 · Pediatric neurology

Background Children and youth with neurofibromatosis type 1 (NF1) commonly experience motor, behavioral, and cognitive problems. Promising findings from an NF1 mouse model suggested that the antioxidant N-acetylcysteine (NAC) might address…

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Negative / Null Result ReportMedicine

Offloading reduces prospective memory learning.

Fellers C, Storm BC · 2026 · Journal of experimental psychology. Learning, memory, and cognition

Across two experiments, we investigated the effects of cognitive offloading on prospective memory (PM). Participants performed two PM tasks, either relying on internal memory for both (Dual PM condition) or using an external reminder for…

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Negative / Null Result ReportMedicine

Automated perfusion imaging did not improve reliability of ASPECTS or collateral score in late-window large vessel occlusion stroke.

Benomar A, Fahed R, Omar AT et al. · 2026 · Journal of neurointerventional surgery

Background The Alberta Stroke Program Early CT Score (ASPECTS) and CT angiography (CTA) Collateral Score (CS) are routinely used to estimate ischemic core burden and collateral status in acute ischemic stroke due to large vessel occlusion,…

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Negative / Null Result ReportOpen accessMedicine

Admission Physiology Appeared More Informative Than Small-for-Gestational-Age Status for Predicting Severe In-Hospital Disposition in Preterm Infants Born at 28-36 Weeks: A Retrospective Single-Center NICU Cohort Study.

Ghorooneh Z, Mohammadzadeh A, Farhat AS et al. · 2026 · BMC pediatrics

BACKGROUND: Whether small for gestational age adds prognostic information after NICU admission physiology is known remains uncertain in preterm infants. This distinction is clinically important because SGA is an anthropometric birth-size…

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Negative / Null Result ReportMedicine

Substantial Operative and Nonoperative Mortality Persists in Neonatal Ebstein Anomaly: A 20-Year Multi-Institutional Analysis.

Turner D, Mehdizadeh-Shrifi A, Faateh M et al. · 2026 · World journal for pediatric & congenital heart surgery

BackgroundWe sought to characterize the epidemiology, treatment patterns, and outcomes of neonatal Ebstein anomaly using a national database.MethodsIn this descriptive analysis, the pediatric health information system (PHIS) database was…

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Negative / Null Result ReportMedicine

Magnetic Resonance Imaging-Based Psoas Muscle Volume as an Additional Risk Factor for Fontan Failure: A Prospective Cohort Study.

Erdem S, Hussain T, Erdem O et al. · 2026 · Journal of the American Heart Association

Background Sarcopenia is prevalent in patients with Fontan circulation and may contribute to functional decline and adverse outcomes. It is commonly assessed using the cross-sectional area of the psoas muscle (PMA), although volumetric…

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Negative / Null Result ReportMedicine

Intrathecal antibody synthesis - Reiber method revisited.

Halperin JJ, Granger D · 2026 · BMC neurology

Background CSF immunoglobulin (IgG) often informs diagnosis in CNS inflammatory disease- qualitatively (oligoclonal bands; OCBs), or quantitatively (CSF: serum IgG: albumin, e.g. IgG index). Most US laboratories estimate excess CSF IgG…

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Negative / Null Result ReportOpen accessMedicine

Risk Stratification of Adverse Outcomes After Heart Transplantation with the 2022 Definition of Pulmonary Hypertension.

Corianò M, Pradegan N, Putortì F et al. · 2026 · Journal of cardiovascular development and disease

Pulmonary hypertension (PH) is associated with adverse outcomes after heart transplantation (HT). In 2022, the European Society of Cardiology introduced lower thresholds for pulmonary vascular resistance (PVR) to distinguish isolated…

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Negative / Null Result ReportMedicine

[Anti-leucine-rich glioma-inactivated 1 antibody-positive encephalitis with a poor response to corticosteroids 2 months after onset of impaired memory: a case report].

Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology

The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…

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Negative / Null Result ReportMedicine

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology

Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…

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Negative / Null Result ReportMedicine

Comparative performance of one-stage and two-stage deep learning models for instance segmentation of overhanging dental restorations on bitewing radiographs.

Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports

Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…

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Negative / Null Result ReportMedicine

The sonographic subpubic area is a predictor of anal incontinence after a first vaginal delivery: A prospective cohort study.

Packet B, Van Severen R, Cattani L et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objectives To study the association between the subpubic arch angle and area, the latter a novel estimator of maternal pelvic outlet dimensions, and postpartum anal incontinence. Methods Convenience sample from a prospective observational…

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Negative / Null Result ReportMedicine

Hand therapy or not following collagenase treatment for Dupuytren's disease? A randomized controlled trial.

Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists

Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…

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Negative / Null Result ReportMedicine

Psychometric Evaluation and Discriminative Validity of the Short-Form Brief Pain Inventory Across Nociceptive, Neuropathic, and Nociplastic Pain Mechanisms.

Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain

The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…

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Negative / Null Result ReportMedicine

Mature oocyte yield in patients with diminished ovarian reserve treated with luteal estradiol priming with or without GnRH antagonist.

Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology

Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…

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Negative / Null Result ReportMedicine

Effect of Piperine Codelivery on the Oral Bioavailability of Cannabidiol: Insights from <i>In Vitro</i> Digestion and <i>In Vivo</i> Pharmacokinetics.

Vardanega R, Lüdtke FL, Loureiro L et al. · 2026 · Journal of agricultural and food chemistry

This study investigated whether coencapsulation of cannabidiol (CBD) and piperine (PIP) in food-grade nanostructured lipid carriers (NLCs) enhances the CBD oral bioavailability. NLCs containing long-chain fatty acids were formulated with…

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Negative / Null Result ReportMedicine

Impact of continuous serratus plane analgesia on quality of recovery after video-assisted thoracic surgery: a prospective double-blind, randomized, placebo-controlled trial.

Biswas A, Zidan H, Kolodzey L et al. · 2026 · Regional anesthesia and pain medicine

Background Video-assisted thoracoscopic surgery (VATS) offers numerous advantages over open surgery; nevertheless, it remains associated with significant postoperative pain. Multiple regional anesthesia techniques have been explored, and…

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Negative / Null Result ReportMedicine

Adjuvant Radiotherapy and Survival in Parotid Gland Adenoid Cystic Carcinoma: A National Cancer Database Analysis.

Kominsky E, Ansari M, Moore M et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective To determine the association of positive margins and adjuvant radiotherapy on overall survival in parotid gland adenoid cystic carcinoma. Study design Retrospective cohort analysis. Setting National Cancer Database from 2004 to…

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Negative / Null Result ReportMedicine

Does Sequential Use of Multiple Chatbots Influence Emergency Guidance for Dental Avulsion?

Buldur M, Sezer B · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background/aim Artificial intelligence-based chatbot systems are increasingly used for dental emergency guidance, yet the clinical value of sequential consultation remains unclear. This study investigated whether response order influences…

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