21,253 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
LaRue-Nolan, Flores, Vera et al. · 2026 · Molecular and cellular biology
Nuclear envelope (NE) proteins are essential for maintaining nuclear morphology, a central process controlling cellular phenotypes. While these proteins and structures are largely characterized in developmental biology, their function and…
View details →Gu, Wen, Liu et al. · 2026 · Circulation
Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion (ie, Na + /H + and Ca 2 + ) cycling underlies reduced cardiac contractility. The…
View details →Srimanan, Sawangsribanterng, Poolsawat et al. · 2026 · Cureus
Internuclear ophthalmoplegia (INO) is a classic neuro-ophthalmologic syndrome caused by disruption of the medial longitudinal fasciculus (MLF), resulting in impaired adduction of the affected eye and abducting nystagmus of the…
View details →Patel, Patel · 2026 · Cureus
Chronic pain is a complex phenomenon whose assessment involves not only physiological but also psychological and social components. Due to its subjective and variable nature, accurately measuring chronic pain remains challenging in both…
View details →Songthap, Wanaratwichit, Mekrungrongwong · 2026 · BMC public health
Despite existing efforts, premarital sex among Thai adolescents remains a critical public health concern, exacerbated by nearly universal smartphone access and prolonged daily digital exposure. Traditional surveillance often fails to…
View details →Krida, Tang, Mangalath et al. · 2026 · Nature communications
Thin-shell structures, found in biological systems such as beetle carapaces and widely used in aerospace and civil engineering, achieve remarkable strength-to-mass ratios given their slenderness and curved geometries. However, their…
View details →Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)
Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…
View details →Cruciani, Cafaro, Perricone et al. · 2026 · Clinical and experimental rheumatology
This study aimed to compare different treatment strategies for rheumatoid arthritis (RA) patients following inadequate response to initial methotrexate (MTX) therapy, evaluating clinical outcomes, tolerability profiles, and factors…
View details →Zhang, Wei, Wu et al. · 2026 · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Alcohol-associated liver disease (ALD) progresses from steatosis to steatohepatitis, but the underlying mechanisms remain unclear. Here, we investigated SETDB1's role in ALD progression involving LC3B-mediated LC3-associated phagocytosis…
View details →Bonglack, Carrel-Lammert, Hoehn et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Acute urinary tract infections (UTIs) are common after prolapse and anti-incontinence surgery, with incidence rates varying from 14% to 64%. The objective was to decrease rates of symptomatic urinary tract infections in patients undergoing…
View details →Mizuno, Chretien, Nishida et al. · 2026 · Journal of gastroenterology
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), including cholangitis, a rare but clinically severe hepatobiliary phenotype. Whether potassium-competitive acid blockers (PCABs) such as vonoprazan are…
View details →Wu, Liu, Wang et al. · 2026 · Scientific reports
Prolonged preoperative fasting is common in pediatric anesthesia, yet its effect on gastric residual volume (GRV) remains inadequately explored. We conducted a prospective cross-sectional study to examine the association between prolonged…
View details →Costa de Oliveira, Caminha Souza, Cândido Alves et al. · 2026 · Clinical nutrition ESPEN
Breast cancer remains a critical global public health concern, with diet representing one of the primary modifiable lifestyle factors influencing both disease prevention and the risk of recurrence. This study aimed to evaluate the…
View details →Pham, Vu, Le et al. · 2026 · PloS one
C5a and its receptor, C5aR, are involved in the degranulation of mast cells and basophils, leading to the release of proinflammatory cytokines. However, to date, their roles in the pathogenesis of chronic spontaneous urticaria (CSU) remain…
View details →Ösken, Çetin · 2026 · Irish journal of medical science
Familial Mediterranean fever (FMF) is characterized by recurrent inflammatory attacks and marked clinical heterogeneity. Exertional leg pain (ELP) is a common but underrecognized manifestation. We aimed to evaluate the association of ELP…
View details →Friese, Wunderl, Jensch et al. · 2026 · American heart journal plus : cardiology research and practice
Arrhythmogenic cardiomyopathy (ACM) is a primary cardiomyopathy associated with mechanical and electrical dysfunction, making diagnosis a clinical challenge. This feasibility study investigates whether Optically Pumped Magnetometer…
View details →Griffith, Zaidan, Gould et al. · 2026 · Cancers
Spinal ependymoma is the most common intramedullary spinal cord tumor in adults, and maximal safe resection is the cornerstone of treatment. Patients aged 75 years and older are underrepresented in surgical neuro-oncology cohorts. We…
View details →Yerkezhan, Sagandykova, Baurzhan et al. · 2026 · Bioengineering (Basel, Switzerland)
Background . Recurrent respiratory papillomatosis (RRP) in children remains a pressing issue in pediatric otolaryngology, characterized by a chronic course, frequent relapses, and the need for repeat surgical interventions. The aim of this…
View details →Tigli, Deniz, Taskin et al. · 2026 · Biomedicines
Background/Objectives : This study aimed to evaluate the association between the clinical parameters of vaginal infection-specifically the presence, type, number of concurrent symptoms, and recurrence frequency-and cervical cytology…
View details →Yagdiran, Kirisci, Uslu et al. · 2026 · BMC nephrology
Pulmonary hypertension (PH) is a complex systemic disease. There are insufficient studies in the literature regarding its effect on renal hemodynamics following transplantation. This retrospective cohort study included 244 kidney…
View details →Boulmpou, Pagourelias, Zormpas et al. · 2026 · Journal of cardiovascular development and disease
Background : Predicting atrial fibrillation (AF) recurrence remains a major clinical challenge, as conventional echocardiographic parameters often fail to capture the complex electro-mechanical substrate of the arrhythmia. The prognostic…
View details →Wain, Steiner, Daddato et al. · 2026 · Journal of the American Geriatrics Society
More than one in four older adults experience a fall each year. While exercise programs are effective in reducing fall-related injuries (FRI), participation remains low due to access barriers. The primary aim of this study was to evaluate…
View details →Zhang, Jia, Hou et al. · 2026 · Endocrine, metabolic & immune disorders drug targets
This study aimed to determine the relationship between Systemic Immune-Inflammation Index (SII) and muscle strength in patients with CKD. This cross-sectional study examined adults with CKD using data from the National Health and Nutrition…
View details →Panwar, Amiri-Kazaz, Szczepaniec · 2026 · Environmental entomology
Amauromyza karli Hendel (Diptera: Agromyzidae) has recently emerged as a damaging stem-boring pest of quinoa in Colorado and other quinoa-producing regions of the United States. Severe infestations have been associated with substantial…
View details →Siddiqui, Ghosh, Ahuja et al. · 2026 · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
Transfusion-dependent beta-thalassemia (TDT) is frequently associated with endocrine dysfunction secondary to hemosiderosis involving multiple organs. This study aimed to evaluate long-term endocrine dysfunction, neuroradiological…
View details →Li, Li, Li et al. · 2026 · Medicine
Inflammation is a recognized driver of tumorigenesis, particularly in breast cancer. The platelet-to-lymphocyte ratio (PLR) has emerged as a readily available inflammatory indicator; however, its independent association with breast cancer…
View details →Ye, Zhang, Du et al. · 2026 · BMC pregnancy and childbirth
To evaluate whether progesterone-induced changes in endometrial thickness (EMT) affect singleton infant outcomes during frozen-thawed embryo transfer (FET) cycles. This retrospective study analyzed 6,331 singleton live births following…
View details →Takekawa, Kinoshita, Ishii et al. · 2026 · BMC anesthesiology
We hypothesized that a shorter preoperative leukocyte telomere length (TL) predicts the development of acute postoperative depression in elderly surgical patients. This single-center, prospective, observational study included 48…
View details →Flores-Flores, Zevallos-Morales, Pollard et al. · 2026 · BMC geriatrics
Multimorbidity, frailty, and depression frequently co-occur in older adults and contribute to adverse health outcomes. This study identified classes of physical multimorbidity and examined their association with depression, and whether…
View details →Wolde, Bae, Raza et al. · 2026 · Journal of epidemiology and global health
Ethiopia remains a high-burden measles setting, yet the drivers of protracted transmission and regional susceptibility remain poorly understood. This study analyzes seven years of national surveillance data to characterize demographic…
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