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Browse the failure-mode index

21,165 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessEnvironmental Science

Conditions associated with protected area success in conservation and poverty reduction

Paul J. Ferraro, Merlin M. Hanauer, Katharine R. E. Sims · 2011 · Proceedings of the National Academy of Sciences

Protected areas are the dominant approach to protecting biodiversity and the supply of ecosystem services. Because these protected areas are often placed in regions with widespread poverty and because they can limit agricultural…

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Negative / Null Result ReportOpen accessSocial Sciences

Wealth, Health, and Child Development: Evidence from Administrative Data on Swedish Lottery Players *

David Cesarini, Erik Lindqvist, Robert Östling et al. · 2016 · The Quarterly Journal of Economics

Abstract We use administrative data on Swedish lottery players to estimate the causal impact of substantial wealth shocks on players’ own health and their children’s health and developmental outcomes. Our estimation sample is large,…

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Replication FailureOpen accessMedicine

Clinical Efficacy of LivPro® Herbal Medicine among Hepatitis C Patients Pakistan: Longitudinal Interventional Study

Irfan Shahîd, Kashif Maqbool Khan, Tahir Mehmood Khan et al. · 2021 · Archives of Pharmacy Practice

The current study aims to investigate the hepatoprotective effects of LivPro® among hepatitis C patients. An interventional study was performed among n=89 hepatitis C patients. The duration of the study was 3 months and the assessment…

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Negative / Null Result ReportOpen accessMedicine

A study investigating the association between vitamin D and depression among university students in 39 countries

Dania Abdul Razzak Kouider, Nageeb Hassan, Yaser Mohammed Al‐Worafi · 2019 · Biomedical Research

Objectives: The aim of this study was to explore the association between vitamin D deficiency and depression among university students and to identify the factors affecting this association. Methodology: A cross-sectional study was…

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Negative / Null Result ReportOpen accessMedicine

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

Trevor Scobey, Boyd L. Yount, Amy Sims et al. · 2013 · Proceedings of the National Academy of Sciences

Severe acute respiratory syndrome with high mortality rates (~50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory syndrome coronavirus (MERS-CoV). We synthesized a panel of contiguous cDNAs that…

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Why Do Individual Investors Disregard Accounting Information? The Roles of Information Awareness and Acquisition Costs

Elizabeth Blankespoor, ED DEHAAN, John E. Wertz et al. · 2018 · Journal of Accounting Research

ABSTRACT We investigate the frictions that impede individual investors’ use of accounting information and, in particular, their costs of monitoring and acquiring accounting disclosures. We do so using an archival setting in which…

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Negative / Null Result ReportSocial Sciences

Is Putin’s popularity real?

Timothy Frye, Scott Gehlbach, Kyle L. Marquardt et al. · 2016 · Post-Soviet Affairs

Vladimir Putin has managed to achieve strikingly high public approval ratings throughout his time as president and prime minister of Russia. But is his popularity real, or are respondents lying to pollsters? We conducted a series of list…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children

Gemma C. Sharp, Debbie A. Lawlor, Rebecca C. Richmond et al. · 2015 · International Journal of Epidemiology

BACKGROUND: Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism. METHODS: We used multivariable linear…

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Negative / Null Result ReportOpen accessSocial Sciences

ONLINE VS. BLENDED LEARNING: DIFFERENCES IN INSTRUCTIONAL OUTCOMES AND LEARNER SATISFACTION

Doo Hun Lim, Michael L. Morris, Virginia W. Kupritz · 2019 · Online Learning

This study investigates differences in instructional and learner factors between two groups of learners exposed to online only and blended delivery formats, respectively, in an effort to compare learning outcomes and other instructional variables between online and blended delivery methods. Findings indicated that no significant differences existed in learning outcomes; however, significant differences existed in several instructional and learner factors between the two delivery format groups. Discussions about improving online or blended delivery method are presented based upon the research f

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

Christopher S. Carlson, Tara C. Matise, Kari E. North et al. · 2013 · PLoS Biology

The vast majority of genome-wide association study (GWAS) findings reported to date are from populations with European Ancestry (EA), and it is not yet clear how broadly the genetic associations described will generalize to populations of diverse ancestry. The Population Architecture Using Genomics and Epidemiology (PAGE) study is a consortium of multi-ancestry, population-based studies formed with the objective of refining our understanding of the genetic architecture of common traits emerging from GWAS. In the present analysis of five common diseases and traits, including body mass index, ty

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Negative / Null Result ReportOpen accessEnvironmental Science

Tropical sea surface temperatures for the past four centuries reconstructed from coral archives

Jessica E. Tierney, Nerilie J. Abram, Kevin J. Anchukaitis et al. · 2015 · Paleoceanography

Abstract Most annually resolved climate reconstructions of the Common Era are based on terrestrial data, making it a challenge to independently assess how recent climate changes have affected the oceans. Here as part of the Past Global…

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Negative / Null Result ReportMedicine

Phase III Trial of Vandetanib Compared With Erlotinib in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Ronald B. Natale, Sumitra Thongprasert, F. Anthony Greco et al. · 2011 · Journal of Clinical Oncology

PURPOSE: Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling. This phase III study assessed the efficacy of vandetanib versus erlotinib in unselected…

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Negative / Null Result ReportMedicine

Pan-Canadian Study of Mammography Screening and Mortality from Breast Cancer

Andrew J. Coldman, Norm Phillips, Christine Wilson et al. · 2014 · JNCI Journal of the National Cancer Institute

BACKGROUND: Screening with mammography has been shown by randomized controlled trials to reduce breast cancer mortality in women aged 40 to 74 years. Estimates from observational studies following screening implementation in different…

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Negative / Null Result ReportOpen accessEngineering

Cobb Angle Measurement of Spine from X-Ray Images Using Convolutional Neural Network

Ming‐Huwi Horng, Chan‐Pang Kuok, Min-Jun Fu et al. · 2019 · Computational and Mathematical Methods in Medicine

Scoliosis is a common spinal condition where the spine curves to the side and thus deforms the spine. Curvature estimation provides a powerful index to evaluate the deformation severity of scoliosis. In current clinical diagnosis, the standard curvature estimation method for assessing the curvature quantitatively is done by measuring the Cobb angle, which is the angle between two lines, drawn perpendicular to the upper endplate of the uppermost vertebra involved and the lower endplate of the lowest vertebra involved. However, manual measurement of spine curvature requires considerable time and

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

New Evidence on the Aftermath of Financial Crises in Advanced Countries

Christina Romer, David Romer · 2017 · American Economic Review

This paper examines the aftermath of postwar financial crises in advanced countries. We construct a new semiannual series on financial distress in 24 OECD countries for the period 1967–2012. The series is based on assessments of the health…

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Negative / Null Result ReportMedicine

Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: Results from a randomized, multicenter, double-blinded, controlled study

Stephen D. Silberstein, David W. Dodick, Joel R. Saper et al. · 2012 · Cephalalgia

BACKGROUND: Chronic migraine (CM) is a debilitating neurological disorder with few treatment options. Peripheral nerve stimulation (PNS) of the occipital nerves is a potentially promising therapy for CM patients. METHODS: In this…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The forgotten flies: the importance of non-syrphid Diptera as pollinators

Katherine A. Orford, Ian P. Vaughan, Jane Memmott · 2015 · Proceedings of the Royal Society B Biological Sciences

Bees, hoverflies and butterflies are taxa frequently studied as pollinators in agricultural and conservation contexts. Although there are many records of non-syrphid Diptera visiting flowers, they are generally not regarded as important…

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Negative / Null Result ReportBusiness, Management and Accounting

Do Big 4 Auditors Provide Higher Audit Quality after Controlling for the Endogenous Choice of Auditor?

John Daniel Eshleman, Peng Guo · 2014 · Auditing A Journal of Practice & Theory

SUMMARY: Recent research suggests that Big 4 auditors do not provide higher audit quality than other auditors, after controlling for the endogenous choice of auditor. We re-examine this issue using the incidence of accounting restatements…

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Negative / Null Result ReportOpen accessPsychology

Proposed declassification of disease categories related to sexual orientation in theInternational Statistical Classification of Diseases and Related Health Problems(ICD-11)

Susan D. Cochran, Jack Drescher, Eszter Kismödi et al. · 2014 · Bulletin of the World Health Organization

The World Health Organization is developing the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11), planned for publication in 2017. The Working Group on the Classification of Sexual Disorders and Sexual Health was charged with reviewing and making recommendations on disease categories related to sexuality in the chapter on mental and behavioural disorders in the 10th revision (ICD-10), published in 1990. This chapter includes categories for diagnoses based primarily on sexual orientation even though ICD-10 states that sexual orientat

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Negative / Null Result ReportOpen accessMathematics

Misuse of DeLong test to compare AUCs for nested models

Olga Demler, Michael Pencina, Ralph B. D’Agostino · 2012 · Statistics in Medicine

The area under the receiver operating characteristics curve (AUC of ROC) is a widely used measure of discrimination in risk prediction models. Routinely, the Mann-Whitney statistics is used as an estimator of AUC, while the change in AUC…

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Negative / Null Result ReportOpen accessMedicine

Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primary analysis of FORWARD I

Kathleen N. Moore, Amit M. Oza, Nicoletta Colombo et al. · 2021 · Annals of Oncology

•In platinum-resistant EOC MIRV did not significantly improve PFS over chemotherapy.•No unexpected toxicities were observed, and tolerability profiles were consistent with those observed in previous studies.•The most promising signals of…

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Extending health insurance to the poor in India: An impact evaluation of Rashtriya Swasthya Bima Yojana on out of pocket spending for healthcare

Anup Karan, Winnie Yip, Ajay Mahal · 2017 · Social Science & Medicine

India launched the 'Rashtriya Swasthya Bima Yojana' (RSBY) health insurance scheme for the poor in 2008. Utilising 3 waves (1999-2000, 2004-05 and 2011-12) of household level data from nationally representative surveys of the National Sample Survey Organisation (NSSO) (N = 346,615) and district level RSBY administrative data on enrolment, we estimated causal effects of RSBY on out-of-pocket expenditure. Using 'difference-in-differences' methods on households in matched districts we find that RSBY did not affect the likelihood of inpatient out-of-pocket spending, the level of inpatient out of p

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Negative / Null Result ReportSocial Sciences

Relation of work-life balance, work-family conflict, and family-work conflict with the employee performance-moderating role of job satisfaction

Aqeel Ahmed Soomro, Robert J. Breitenecker, Syed Afzal Shah · 2018 · South Asian Journal of Business Studies

Purpose People in both the developing and developed worlds now face issues like work-to-family and family-to-work conflicts. Accordingly, the purpose of this paper is to explore the relationships between work-life balance, work-family…

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Negative / Null Result ReportOpen accessEnvironmental Science

Explaining Extreme Events of 2012 from a Climate Perspective

T. C. Peterson, Martin P. Hoerling, Peter A. Stott et al. · 2013 · Bulletin of the American Meteorological Society

Attribution of extreme events is a challenging science and one that is currently undergoing considerable evolution. In this paper are 19 analyses by 18 different research groups, often using quite different methodologies, of 12 extreme…

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