Negative / Null Result ReportMedicine
Brian O’Sullivan, Anthony M. Griffin, Colleen Dickie et al. · 2013 · Cancer
BACKGROUND: This study sought to determine if preoperative image-guided intensity-modulated radiotherapy (IG-IMRT) can reduce morbidity, including wound complications, by minimizing dose to uninvolved tissues in adults with lower extremity…
View details →Negative / Null Result ReportOpen accessMedicine
NiCole A. Finch, Minerva M. Carrasquillo, Matthew Baker et al. · 2010 · Neurology
OBJECTIVES: To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B…
View details →Negative / Null Result ReportOpen accessMedicine
Michael A. Yassa, L. Tugan Muftuler, Craig E.L. Stark · 2010 · Proceedings of the National Academy of Sciences
The perforant path (PP) undergoes synaptic changes in the course of aging and dementia. Previous studies attempting to assess the integrity of the PP in humans using diffusion tensor imaging (DTI) were limited by low resolution and the…
View details →Negative / Null Result ReportOpen accessMedicine
Alessandro Tarozzi, Aprajit Mahajan, Brian G. Blackburn et al. · 2014 · American Economic Review
We describe findings from the first large-scale cluster randomized controlled trial in a developing country that evaluates the uptake of a health-protecting technology, insecticide-treated bednets (ITNs), through micro-consumer loans, as…
View details →Negative / Null Result ReportOpen accessMedicine
Katherine M.W. Pisters, Eric Vallières, John J. Crowley et al. · 2010 · Journal of Clinical Oncology
PURPOSE Patients with early-stage non-small-cell lung cancer (NSCLC) have a poor prognosis even after complete resection. Earlier studies of preoperative (induction) chemotherapy in resectable NSCLC demonstrated feasibility and encouraging…
View details →Negative / Null Result ReportOpen accessMedicine
Brian A. Walker, Christopher P. Wardell, Lorenzo Melchor et al. · 2012 · Blood
We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the mutational landscape. Each case was characterized by a median of 24.5 exonic nonsynonymous single-nucleotide…
View details →Negative / Null Result ReportMedicine
Leonard B. Saltz, Stephen Clarke, Eduardo Díaz‐Rubio et al. · 2023 · Journal of Clinical Oncology
Purpose To evaluate the efficacy and safety of bevacizumab when added to first-line oxaliplatin-based chemotherapy (either capecitabine plus oxaliplatin [XELOX] or fluorouracil/folinic acid plus oxaliplatin [FOLFOX-4]) in patients with…
View details →Replication FailureOpen accessMedicine
Michelle L. O’Donoghue, Ruchira Glaser, Matthew A. Cavender et al. · 2016 · JAMA
IMPORTANCE: p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST…
View details →Negative / Null Result ReportOpen accessMedicine
Paulina Aleksandrowicz, Andrea Marzi, Nadine Biedenkopf et al. · 2011 · The Journal of Infectious Diseases
Virus entry into host cells is the first step of infection and a crucial determinant of pathogenicity. Here we show that Ebola virus-like particles (EBOV-VLPs) composed of the glycoprotein GP(1,2) and the matrix protein VP40 use…
View details →Negative / Null Result ReportOpen accessMedicine
Frederic T. Billings, Patricia A. Hendricks, Jonathan S. Schildcrout et al. · 2016 · JAMA
IMPORTANCE: Statins affect several mechanisms underlying acute kidney injury (AKI). OBJECTIVE: To test the hypothesis that short-term high-dose perioperative atorvastatin would reduce AKI following cardiac surgery. DESIGN, SETTING, AND…
View details →Negative / Null Result ReportOpen accessMedicine
Gillian C. Barnett, Charlotte E. Coles, Rebecca Elliott et al. · 2011 · The Lancet Oncology
BACKGROUND: Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset. METHODS: 92 (of 98 attempted) SNPs in 46 genes were successfully genotyped in 1613 patients: 976 received adjuvant breast radiotherapy in the Cambridge breast IMRT trial (ISRCTN21474421, n=942) or in a prospective study of breast toxicity at the Chris
View details →Negative / Null Result ReportOpen accessMedicine
David T. Levy, Kenneth E. Warner, K. Michael Cummings et al. · 2018 · Tobacco Control
BACKGROUND: The 2018 National Academies of Sciences, Engineering, and Medicine Report found substantial evidence that electronic cigarette use (vaping) by youth is strongly associated with an increased risk of ever using cigarettes…
View details →Negative / Null Result ReportOpen accessMedicine
Noémie Travier, Miranda J. Velthuis, Charlotte N. Steins Bisschop et al. · 2015 · BMC Medicine
BACKGROUND: Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue. METHODS: This multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy
View details →Negative / Null Result ReportOpen accessMedicine
Rainer Meierhenrich, Elisa Steinhilber, Christian Eggermann et al. · 2010 · Critical Care
INTRODUCTION: Since data regarding new-onset atrial fibrillation (AF) in septic shock patients are scarce, the purpose of the present study was to evaluate the incidence and prognostic impact of new-onset AF in this patient group. METHODS: We prospectively studied all patients with new-onset AF and all patients suffering from septic shock in a non-cardiac surgical intensive care unit (ICU) during a 13 month period. RESULTS: During the study period, 687 patients were admitted to the ICU, of which 58 patients were excluded from further analysis due to pre-existing chronic or intermittent AF. In
View details →Negative / Null Result ReportOpen accessMedicine
Weimin Cai, Jun Xu, Xiao Wu et al. · 2023 · Cardiovascular Diabetology
Abstract Background The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG index in patients with severe stroke requiring ICU admission remains unclear. The aim of this study was to investigate the association between the TyG index and clinical prognosis of critically ill patients with ischemic stroke (IS). Methods This study identified patients with severe IS requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV)
View details →Negative / Null Result ReportOpen accessMedicine
Gabrielle Campbell, Wayne Hall, Amy Peacock et al. · 2018 · The Lancet Public Health
BACKGROUND: Interest in the use of cannabis and cannabinoids to treat chronic non-cancer pain is increasing, because of their potential to reduce opioid dose requirements. We aimed to investigate cannabis use in people living with chronic…
View details →Negative / Null Result ReportOpen accessMedicine
Steven Boonen, Jan Van Meirhaeghe, L. Bastian et al. · 2011 · Journal of Bone and Mineral Research
Vertebral fractures are often painful and lead to reduced quality of life and disability. We compared the efficacy and safety of balloon kyphoplasty to nonsurgical therapy over 24 months in patients with acute painful fractures. Adults…
View details →Negative / Null Result ReportMedicine
Azucena Pérez‐Burgos, Bingxian Wang, Yukang Mao et al. · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Mounting evidence supports the influence of the gut microbiome on the local enteric nervous system and its effects on brain chemistry and relevant behavior. Vagal afferents are involved in some of these effects. We previously showed that…
View details →Negative / Null Result ReportOpen accessMedicine
Zoe Moodie, Leah Price, Cécile Gouttefangeas et al. · 2010 · Cancer Immunology Immunotherapy
No consensus has been reached on how to determine if an immune response has been detected based on raw data from an ELISPOT assay. The goal of this paper is to enable investigators to understand and readily implement currently available…
View details →Negative / Null Result ReportOpen accessMedicine
Masanari Kuwabara, Koichiro Niwa, Ichiro Hisatome et al. · 2017 · Hypertension
Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify the association between asymptomatic…
View details →Negative / Null Result ReportOpen accessMedicine
Inessa Bekerman, Paul Gottlieb, Michael Vaiman · 2014 · Journal of Ophthalmology
The purpose of the current research was to reevaluate the normative data on the eyeball diameters. Methods. In a prospective cohort study, the CT data of consecutive 250 adults with healthy eyes were collected and analyzed, and sagittal, transverse, and axial diameters of both eyeballs were measured. The data obtained from the left eye and from the right eye were compared. The correlation analysis was performed with the following variables: orbit size, gender, age, and ethnic background. Results. We did not find statistically significant differences correlated with gender of the patients and t
View details →Negative / Null Result ReportOpen accessMedicine
Thamaraiselvan Murugan, Sugumari Elavarasu, Thangakumaran Suthanthiran et al. · 2014 · Journal of Indian Society of Periodontology
AIM: The aim of this study was to determine whether the addition of an autologous platelet rich fibrin (PRF) membrane to a coronally advanced flap (CAF) would improve the clinical outcome in terms of root coverage, in the treatment of…
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Firanescu, Jolanda De Vries, Paul Lodder et al. · 2018 · BMJ
OBJECTIVE: To assess whether percutaneous vertebroplasty results in more pain relief than a sham procedure in patients with acute osteoporotic compression fractures of the vertebral body. DESIGN: Randomised, double blind, sham controlled…
View details →Negative / Null Result ReportOpen accessMedicine
James W. Welsh, Stephen H. Settle, Arya Amini et al. · 2011 · Cancer
BACKGROUND: Local failure after definitive chemoradiation therapy for unresectable esophageal cancer remains problematic. Little is known about the failure pattern based on modern-day radiation treatment volumes. We hypothesized that most…
View details →Negative / Null Result ReportOpen accessMedicine
Davy Vancampfort, Joseph Firth, Christoph U. Correll et al. · 2019 · World Psychiatry
We summarized and compared meta-analyses of pharmacological and non-pharmacological interventions targeting physical health outcomes among people with schizophrenia spectrum disorders. Major databases were searched until June 1, 2018. Of…
View details →Negative / Null Result ReportOpen accessMedicine
Ingrid L. Holster, Eric T.T.L. Tjwa, Adriaan Moelker et al. · 2015 · Hepatology
UNLABELLED: Gastroesophageal variceal bleeding in patients with cirrhosis is associated with significant morbidity and mortality, as well as a high rebleeding risk. Limited data are available on the role of transjugular intrahepatic…
View details →Negative / Null Result ReportOpen accessMedicine
Allison E. Aiello, Vanessa Pérez, Rebecca M. Coulborn et al. · 2012 · PLoS ONE
UNLABELLED: Limited vaccine availability and the potential for resistance to antiviral medications have led to calls for establishing the efficacy of non-pharmaceutical measures for mitigating pandemic influenza. Our objective was to examine if the use of face masks and hand hygiene reduced rates of influenza-like illness (ILI) and laboratory-confirmed influenza in the natural setting. A cluster-randomized intervention trial was designed involving 1,178 young adults living in 37 residence houses in 5 university residence halls during the 2007-2008 influenza season. Participants were assigned t
View details →Negative / Null Result ReportOpen accessMedicine
Laura García, Brandon Birckhead, Parthasarathy Krishnamurthy et al. · 2021 · Journal of Medical Internet Research
BACKGROUND: Chronic low back pain is the most prevalent chronic pain condition worldwide and access to behavioral pain treatment is limited. Virtual reality (VR) is an immersive technology that may provide effective behavioral therapeutics for chronic pain. OBJECTIVE: We aimed to conduct a double-blind, parallel-arm, single-cohort, remote, randomized placebo-controlled trial for a self-administered behavioral skills-based VR program in community-based individuals with self-reported chronic low back pain during the COVID-19 pandemic. METHODS: A national online convenience sample of individuals
View details →Negative / Null Result ReportOpen accessMedicine
Min Cao, Guozheng Wang, Jianfeng Xie · 2023 · Cell Death Discovery
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious hazard to human health, but it also imposes a substantial economic burden on the healthcare system. The cornerstones of current treatment for sepsis remain source control, fluid resuscitation, and rapid administration of antibiotics, etc. To date, no drugs have been approved for treating sepsis, and most clinical trials of potential therapies have failed to reduce mortality. The immune response caused by the pathogen is complex, resulting in a dysregul
View details →Negative / Null Result ReportOpen accessMedicine
Roy N. Alcalay, Tama Dinur, Timothy J. Quinn et al. · 2014 · JAMA Neurology
IMPORTANCE: Information on age-specific risk for Parkinson disease (PD) in patients with Gaucher disease (GD) and glucocerebrosidase (GBA) heterozygotes is important for understanding the pathophysiology of the genetic association and for…
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