Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study
Gillian C. Barnett; Charlotte E. Coles; Rebecca Elliott; Caroline Baynes; Craig Luccarini; Don Conroy; Jennifer Wilkinson; Jonathan P. Tyrer · 2011 · The Lancet Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset. METHODS: 92 (of 98 attempted) SNPs in 46 genes were successfully genotyped in 1613 patients: 976 received adjuvant breast radiotherapy in the Cambridge breast IMRT trial (ISRCTN21474421, n=942) or in a prospective study of breast toxicity at the Chris
Abstract by Gillian C. Barnett; Charlotte E. Coles; Rebecca Elliott; Caroline Baynes; Craig Luccarini; Don Conroy; Jennifer Wilkinson; Jonathan P. Tyrer, The Lancet Oncology (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/s1470-2045(11)70302-3