Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction
Michelle L. O’Donoghue; Ruchira Glaser; Matthew A. Cavender; Philip E. Aylward; Marc P. Bonaca; Andrzej Budaj; Richard Y. Davies; Mikael Dellborg · 2016 · JAMA
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
IMPORTANCE: p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST…
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Metadata source: OpenAlex · DOI 10.1001/jama.2016.3609