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WASTE Journal

Browse the failure-mode index

12,241 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

C4/5 Facetectomy Is Associated With Improved Recovery of C5 Palsy in Severe Foraminal Stenosis After Posterior Cervical Decompression and Fusion.

Nakamura Y, Murata S, Yabe T et al. · 2026 · Cureus

Introduction C5 palsy is a disabling complication after posterior cervical decompression and fusion (PCDF). Whether C4/5 facetectomy reduces the incidence or improves the outcomes of C5 palsy remains uncertain. Therefore, this study aimed…

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Negative / Null Result ReportMedicine

Questioning routine antibiotic prophylaxis in sialendoscopy: a single-surgeon 164-case analysis.

Holland K, Gomeniouk O, Owen GS et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Determine if there is a difference in post-operative infection rates in patients undergoing sialendoscopy who received pre-, post-operative, both pre and post, or no antibiotics. Methods Retrospective chart review of patients who…

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Negative / Null Result ReportMedicine

Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted S. aureus Vaccine in Adults with Recent Skin And Soft Tissue Infections: An Observer-blind, Randomized, Placebo-controlled, Multinational Phase 1/2 Trial.

Athan E, Greenberg RN, Baker DA et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background A vaccine that prevents Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) would have a major impact on public health. Methods A two-part randomized study began with a phase 1, first-in-human, dose-escalation that…

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Negative / Null Result ReportMedicine

Prevention of premature birth: Impact of the Explicit Health Guarantee.

Carvajal-Encina F, Carvajal Rojas L · 2025 · Andes pediatrica : revista Chilena de pediatria

Prematurity is a challenge due to its high morbidity and mortality. The Explicit Health Guarantees (GES) for Premature Birth Prevention, implemented in 2005, have not been evaluated. Objective To evaluate the impact of the GES on perinatal…

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Negative / Null Result ReportOpen accessMedicine

Effect of Erector Spinae Plane Block Applied to Painful Herpes Zoster Patients Who Failed to Respond to Pregabalin Treatment on Immunological Marker Levels and Postherpetic Neuralgia Incidence Rate.

Büyükbezirci G, Demiralp N, Keles S et al. · 2026 · Journal of pain research

Purpose Postherpetic neuralgia (PHN) is one of the most debilitating complications of herpes zoster and represents a major cause of chronic neuropathic pain. Increasing evidence suggests that immune dysregulation plays a critical role in…

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Negative / Null Result ReportOpen accessMedicine

Intraoperative hypotension after remimazolam or propofol induction with sevoflurane maintenance in angiotensin II receptor blockers-treated patients: a randomized controlled trial.

Kim HJ, Kim N, Kim J et al. · 2025 · Scientific reports

Robot-assisted laparoscopic prostatectomy (RALP) is associated with hemodynamic shifts; patients on angiotensin receptor blockers (ARBs) are especially susceptible to intraoperative hypotension. We investigated whether induction with…

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Negative / Null Result ReportMedicine

Increase in Diaphragm and Expiratory respiratory muscles thickness is not associated with postoperative pulmonary complications after thoracic surgery: A prospective ultrasound cohort study.

Berthoud V, Nguyen M, Vinay J et al. · 2026 · Anaesthesia, critical care & pain medicine

Introduction In thoracic surgery, all respiratory muscles have a significant increase in workload, and recruitment of these muscles may be important, especially in the presence of diaphragmatic dysfunction. Evaluating diaphragmatic and…

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Negative / Null Result ReportMedicine

Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.

Perez-Valero I, Corona Mata D, Crussells Canales MJ et al. · 2026 · International journal of antimicrobial agents

Objective To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsychiatric…

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Negative / Null Result ReportMedicine

Prophylactic Subcutaneous Heparin Is Not Associated With Increased Rates of Hematoma, Pulmonary Embolism, or Deep Vein Thrombosis Following Lumbar Fusion: A Multi-Institutional, Propensity Score-Matched Analysis of 3106 Patients.

Crawford AM, Striano BM, Schoenfeld AJ et al. · 2026 · Spine

Study design Retrospective multicenter cohort study. Objective To compare the safety and efficacy of venous thromboembolism prophylaxis (VTE) strategies between two high-volume spine centers with distinct protocols. Summary of background…

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Negative / Null Result ReportMedicine

Ambulatory care by on-call teams in an Emergency Department.

Kinsella A, Gilligan P · 2025 · Irish medical journal

Aim Admission rate is a key performance indicator for Emergency Departments (EDs). Senior hospital management advised that, if discharge by on-call teams was possible within 24 hours, a patient should be termed 'ambulatory' and remain in…

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Negative / Null Result ReportMedicine

Efficacy of topical hydrophilic gel of paromomycin combined with systemic or locally administered leishmanicidal drugs for treatment of experimental leishmaniasis caused by Leishmania (Viannia) braziliensis.

Alves LL, Pinheiro Rosa DC, Freire ML et al. · 2025 · The Journal of antimicrobial chemotherapy

Objective This study aimed at evaluating the combination of a topical hydrophilic gel of paromomycin (PA) with intralesion meglumine antimoniate (Glu IL) or systemic administration of liposomal amphotericin B (AmphLipo) for the treatment…

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Negative / Null Result ReportOpen accessMedicine

Diaryl-Aminoindazole with Extensive In Vitro Mycobactericidal Activity Dependent on Exposure to Reactive Nitrogen Species.

Warrier T, Martínez-Hoyos M, Porras De Francisco E et al. · 2026 · ACS infectious diseases

A bromoindazole was reported with the ability to rapidly and extensively kill Mycobacterium tuberculosis (Mtb) in vitro, but only in the presence of sublethal levels of reactive nitrogen species (RNS) (Warrier et al., ACS Infectious…

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Negative / Null Result ReportMedicine

Impact of daily adaptive head and neck radiotherapy on toxicity and quality of life: results of the DARTBOARD phase II randomized trial.

Sher DJ, Avkshtol V, Lin MH et al. · 2025 · Journal of the National Cancer Institute

Background The utility of adaptive radiotherapy (ART) for head and neck squamous cell carcinoma (HNSCC) remains poorly defined. Daily ART (DART) promises both anatomic adaptation and planning target volume (PTV) reduction. In this…

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Negative / Null Result ReportMedicine

The Moderating Effect of Social Skills and Social Support on the Association Between Poverty Ratio and Health Promotion Behaviors in Adolescence.

Furman CR, Worth IA, Zhang JD et al. · 2025 · Behavioral medicine (Washington, D.C.)

Eating and exercise habits established in adolescence are associated with immediate and long-term health outcomes. These habits may be influenced by adolescents' socioeconomic status (SES), such that low SES households often experience…

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