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WASTE Journal

Browse the failure-mode index

12,375 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Exploring the Effects of Saturated and Transition-Metal-Substituted Dawson Doping on Electrocatalytic CO<sub>2</sub> Reduction Activity in P<sub>2</sub>W<sub>18</sub>@PCN-222 and P<sub>2</sub>W<sub>17</sub>M@PCN-222 (M = Co, Mn, Ni) Composites.

Li C, Shu L, Teng YL et al. · 2026 · Inorganic chemistry

To exploit the electron-sponge properties of polyoxometalates (POMs) and elucidate the mechanistic impact of doping with saturated versus metal-substituted Dawson-type POMs on electrocatalytic CO 2 reduction, P 2 W 18 @PCN-222 and P 2 W 17…

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Negative / Null Result ReportMedicine

Effect of a parent-supported psychosocial development program on psychosocial outcomes of children aged 1-3 years: a waiting-list randomized controlled trial.

Cirlak A, Kacan H · 2026 · Irish journal of medical science

BACKGROUND: Parent-supported psychosocial development programs aim to strengthen the parent-child relationship and promote healthy early childhood development, particularly in settings where access to structured preventive interventions is…

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Replication FailureMedicine

Mineralocorticoid Receptor Antagonists in Dialysis.

Elenjickal EJ, Mavrakanas TA · 2026 · American journal of nephrology

Background Aldosterone regulates genes controlling fluid and electrolyte balance through mineralocorticoid receptor (MR) activation. Sustained MR activation promotes inflammation, fibrosis, sodium retention, and myocardial remodeling. MR…

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Negative / Null Result ReportMedicine

Effects of the ABCDEF Bundle on Delirium, Function, and Quality of Life in Australian ICU Patients: A Pragmatic Randomized Controlled Trial.

Sosnowski KJ, Ranse KL, Mitchell ML et al. · 2026 · Critical care medicine

Objectives To test whether the ABCDEF bundle, compared with usual care, decreases delirium incidence and duration, improves functional status in the ICU, and enhances 90-day post-ICU discharge quality of life in critically ill Australian…

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Negative / Null Result ReportMedicine

Pre-Endoscopic Retrograde Cholangiopancreatography Cholangitis and Stent Outcomes in Malignant Distal Biliary Obstruction: A Multicenter Propensity Score-Matched Analysis.

Niiya F, Satoh T, Kobayashi Y et al. · 2026 · Digestive diseases and sciences

Background Clinical evidence on whether acute cholangitis accelerates early stent failure via rapid bacterial adhesion and biofilm formation remains limited. We assessed the influence of pre-endoscopic retrograde cholangiopancreatography…

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Negative / Null Result ReportMedicine

Mechanisms reducing parasympathetic activity in chronic hypoxia.

Maier LE, Douglas A, Foster K et al. · 2026 · The Journal of physiology

Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. We investigated whether (i) arterial chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii) pulmonary stretch, (iv)…

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Negative / Null Result ReportMedicine

[Efficacy and safety of ticagrelor versus clopidogrel after percutaneous coronary intervention in patients with acute coronary syndrome without standard modifiable cardiovascular risk factors].

Na K, Qiu MH, Wang ZH et al. · 2026 · Zhonghua xin xue guan bing za zhi

Objective: To evaluate the efficacy and safety of ticagrelor versus clopidogrel in real-world patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRF-less) following percutaneous coronary…

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Negative / Null Result ReportMedicine

Overcoming doramectin failure: field efficacy of pour-on 5% fluralaner and an experimental 1% oral formulation for the prevention of Cochliomyia hominivorax-associated umbilical myiasis in newborn calves.

de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors

Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…

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Negative / Null Result ReportOpen accessMedicine

Cardiovascular pharmacotherapy in 2025.

Tamargo J, Agewall S, Ambrosio G et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy

Despite recent advances in cardiovascular pharmacotherapy, prevention and treatment of many cardiovascular diseases remain limited with a clear need for more effective and safer pharmacological strategies. Here, we summarize the most…

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Negative / Null Result ReportMedicine

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.

Sárkány F, Priksz D, Juhász B et al. · 2026 · Basic research in cardiology

Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…

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Negative / Null Result ReportMedicine

Do coexistent overactive bladder symptoms affect the outcome of single-incision sling in women with urodynamic stress incontinence?

Hsieh TH, Liang CC, Liang CY et al. · 2026 · Taiwanese journal of obstetrics & gynecology

Objective To explore whether preoperative overactive bladder (OAB) symptoms affect the outcome of single-incision slings (SIS) for urodynamic stress incontinence (USI). Materials and methods This retrospective study involved 106 patients…

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Negative / Null Result ReportMedicine

Antimicrobial strategies for ureteral stent removal after radical cystectomy: a comparative cohort study.

Mangold MH, Kazmierczak J, Gerigk M et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

INTRODUCTION: Patients undergoing radical cystectomy (RC) face a heightened risk of infectious complications around the time of ureteral stent removal. This study aimed to determine whether a culture-guided antimicrobial strategy reduces…

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Negative / Null Result ReportMedicine

Single-injection adductor canal block with perineural dexamethasone versus continuous adductor canal catheter for total knee arthroplasty: a randomized controlled trial.

Kim DH, Beathe J, Wetmore DS et al. · 2026 · Regional anesthesia and pain medicine

Background The adductor canal block (ACB), known for its motor-sparing properties, has gained popularity as part of the multimodal analgesic regimen in total knee arthroplasty (TKA) patients. However, the duration of single-injection…

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