Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.
Sárkány F; Priksz D; Juhász B; Fazekas LÁ; Németh N; Szentandrássy N; Horváth B; Kovács ZM · 2026 · Basic research in cardiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…
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Metadata source: Europe PMC · DOI 10.1007/s00395-026-01194-5