12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
The INIS Collaborative Group · 2011 · New England Journal of Medicine
BACKGROUND: Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. Meta-analyses of…
View details →William G. Lindsley, Terri Pearce, Judith B. Hudnall et al. · 2012 · Journal of Occupational and Environmental Hygiene
The question of whether influenza is transmitted to a significant degree by aerosols remains controversial, in part, because little is known about the quantity and size of potentially infectious airborne particles produced by people with…
View details →Mihai Gheorghiade, Michael Böhm, Stephen J. Greene et al. · 2013 · JAMA
IMPORTANCE: Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge rehospitalization and mortality. OBJECTIVE: To investigate whether aliskiren, a direct renin inhibitor, when added…
View details →Yan Wang, Fabiana Quagliarini, Viktoria Gusarova et al. · 2013 · Proceedings of the National Academy of Sciences
Angiopoietin-like protein (ANGPTL)8 (alternatively called TD26, RIFL, Lipasin, and Betatrophin) is a newly recognized ANGPTL family member that has been implicated in both triglyceride (TG) and glucose metabolism. Hepatic overexpression of…
View details →Alice G. Cheng, Molly McAdow, Hwan Keun Kim et al. · 2010 · PLoS Pathogens
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited wi
View details →Rolf Jorde, Monica Sneve, Peter A. Torjesen et al. · 2010 · Nutrition Journal
BACKGROUND: In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of vitamin D on BMD is more uncertain and could in theory have both positive and negative effects. METHODS: The study was a one year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway. 421 subjects, 21 - 70 years old, were included and 312 com
View details →Gabrielle Kingsley, Anna Kowalczyk, Helen Taylor et al. · 2012 · Lara D. Veeken
OBJECTIVE: MTX is widely used to treat synovitis in PsA without supporting trial evidence. The aim of our study was to test the value of MTX in the first large randomized placebo-controlled trial (RCT) in PsA. METHODS: A 6-month…
View details →Julie Agel, Todd Rockwood, David Klossner · 2016 · Clinical Journal of Sport Medicine
OBJECTIVE: To present data on the rate of anterior cruciate ligament (ACL) injury in 15 collegiate sports from 2004 to 2005 through 2012 to 2013 updating the 1988-1989 to 2003-2004 data. DESIGN: Prospectively designed descriptive…
View details →Luis Paz‐Ares, Y Chen, Niels Reinmuth et al. · 2022 · ESMO Open
•Durvalumab plus EP showed sustained OS benefit over EP with a well-tolerated safety profile after median follow-up >3 years.•Three times more patients were estimated to be alive at 3 years when treated with durvalumab plus EP versus EP…
View details →Lucy van Dorp, Damien Richard, Cedric Tan et al. · 2020 · Nature Communications
COVID-19 is caused by the coronavirus SARS-CoV-2, which jumped into the human population in late 2019 from a currently uncharacterised animal reservoir. Due to this recent association with humans, SARS-CoV-2 may not yet be fully adapted to its human host. This has led to speculations that SARS-CoV-2 may be evolving towards higher transmissibility. The most plausible mutations under putative natural selection are those which have emerged repeatedly and independently (homoplasies). Here, we formally test whether any homoplasies observed in SARS-CoV-2 to date are significantly associated with inc
View details →Justin Beardsley, Marcel Wolbers, Freddie Kibengo et al. · 2016 · New England Journal of Medicine
BACKGROUND: Cryptococcal meningitis associated with human immunodeficiency virus (HIV) infection causes more than 600,000 deaths each year worldwide. Treatment has changed little in 20 years, and there are no imminent new anticryptococcal…
View details →Biren B. Kamdar, Lauren M. King, Nancy A. Collop et al. · 2013 · Critical Care Medicine
OBJECTIVES: To determine if a quality improvement intervention improves sleep and delirium/cognition. DESIGN: Observational, pre-post design. SETTING: A tertiary academic hospital in the United States. PATIENTS: 300 medical ICU patients.…
View details →Luke Macyszyn, Hamed Akbari, Jared Pisapia et al. · 2015 · Neuro-Oncology
BACKGROUND: MRI characteristics of brain gliomas have been used to predict clinical outcome and molecular tumor characteristics. However, previously reported imaging biomarkers have not been sufficiently accurate or reproducible to enter…
View details →Song‐Yi Park, Neal D. Freedman, Christopher A. Haiman et al. · 2017 · Annals of Internal Medicine
BACKGROUND: Coffee consumption has been associated with reduced risk for death in prospective cohort studies; however, data in nonwhites are sparse. OBJECTIVE: To examine the association of coffee consumption with risk for total and…
View details →Bjarne M. Nes, Imre Janszky, Ulrik Wisløff et al. · 2012 · Scandinavian Journal of Medicine and Science in Sports
Maximal heart rate (HRmax ) declines substantially with age, but the magnitude and possible modifying effect of gender, body composition, and physical activity are not fully established. The present study examined the relationship between…
View details →Irfan Shahîd, Kashif Maqbool Khan, Tahir Mehmood Khan et al. · 2021 · Archives of Pharmacy Practice
The current study aims to investigate the hepatoprotective effects of LivPro® among hepatitis C patients. An interventional study was performed among n=89 hepatitis C patients. The duration of the study was 3 months and the assessment…
View details →T.J. Bonner, William Eardley, Paul R. Patterson et al. · 2011 · Journal of Bone and Joint Surgery - British Volume
Correct positioning and alignment of components during primary total knee replacement (TKR) is widely accepted to be an important predictor of patient satisfaction and implant durability. This retrospective study reports the effect of the…
View details →Dania Abdul Razzak Kouider, Nageeb Hassan, Yaser Mohammed Al‐Worafi · 2019 · Biomedical Research
Objectives: The aim of this study was to explore the association between vitamin D deficiency and depression among university students and to identify the factors affecting this association. Methodology: A cross-sectional study was…
View details →Trevor Scobey, Boyd L. Yount, Amy Sims et al. · 2013 · Proceedings of the National Academy of Sciences
Severe acute respiratory syndrome with high mortality rates (~50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory syndrome coronavirus (MERS-CoV). We synthesized a panel of contiguous cDNAs that…
View details →Ronald B. Natale, Sumitra Thongprasert, F. Anthony Greco et al. · 2011 · Journal of Clinical Oncology
PURPOSE: Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling. This phase III study assessed the efficacy of vandetanib versus erlotinib in unselected…
View details →Andrew J. Coldman, Norm Phillips, Christine Wilson et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Screening with mammography has been shown by randomized controlled trials to reduce breast cancer mortality in women aged 40 to 74 years. Estimates from observational studies following screening implementation in different…
View details →Stephen D. Silberstein, David W. Dodick, Joel R. Saper et al. · 2012 · Cephalalgia
BACKGROUND: Chronic migraine (CM) is a debilitating neurological disorder with few treatment options. Peripheral nerve stimulation (PNS) of the occipital nerves is a potentially promising therapy for CM patients. METHODS: In this…
View details →Kathleen N. Moore, Amit M. Oza, Nicoletta Colombo et al. · 2021 · Annals of Oncology
•In platinum-resistant EOC MIRV did not significantly improve PFS over chemotherapy.•No unexpected toxicities were observed, and tolerability profiles were consistent with those observed in previous studies.•The most promising signals of…
View details →Maria Justine, Azliyana Azizan, Vally Hassan et al. · 2013 · Singapore Medical Journal
INTRODUCTION Although the benefits of physical activity and exercise are widely acknowledged, many middle-aged and elderly individuals remain sedentary. This cross-sectional study aimed to identify the external and internal barriers to…
View details →Navneet Singh, Stephen J. Hopkins, Sharon Hulme et al. · 2014 · Journal of Neuroinflammation
BACKGROUND: Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood-brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. METHODS: A small phase II, double-blind, randomised controlled study was carried out across two UK neurosurgical centres
View details →Matthew J. Reilley, Patricia McCoon, Carl Cook et al. · 2018 · Journal for ImmunoTherapy of Cancer
BACKGROUND: The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activation of immune responses. In diffuse large B-cell lymphoma (DLBCL), the transcription factor STAT3 has been associated with aggressive disease phenotype and worse overall survival. While multiple therapies inhibit upstream signaling, there has been limited success in selectively targeting STAT3 in patients. Antisense oligonucleotides (ASOs) represent a comp
View details →Huijuan Wu, Christopher P. Larsen, Cesar F. Hernandez-Arroyo et al. · 2020 · Journal of the American Society of Nephrology
Significance Statement Kidney involvement may occur in coronavirus disease 2019 (COVID-19), and can be severe among Black individuals. In this study of collapsing glomerulopathy in six Black patients with COVID-19, the authors found that…
View details →Gaurav Aggarwal, Giuseppe Lippi, Brandon Michael Henry · 2020 · International Journal of Stroke
INTRODUCTION: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.…
View details →Felipe Lobelo, Isabel Garcia de Quevedo · 2014 · American Journal of Lifestyle Medicine
Physical inactivity constitutes the fourth leading cause of death worldwide. Health care providers (HCPs) should play a key role in counseling and appropriately referring their patients to adopt physical activity (PA). Previous reports…
View details →Chris Eijsbouts, Tenghao Zheng, Nicholas A. Kennedy et al. · 2021 · Nature Genetics
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1 ,
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