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Browse the failure-mode index

12,240 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Voir La Vie Sans Rose-Colored Glasses.

Paap K, Majoubi J · 2025 · Experimental psychology

In a recent article, Ellen Bialystok argued that bilingual experience enhances nonverbal cognition, that its effects are continuous rather than categorical, and that selective attention is the key mechanism underlying cognitive changes in…

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Negative / Null Result ReportMedicine

Parental oral health knowledge and sociodemographic influences in children aged 2-12 years: a cross-sectional study in Valencia, Spain.

Borrell-García, Mestanza-Tocto, Boo-Gordillo et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

The present study aimed to assess parental knowledge of paediatric oral health among parents and guardians of children aged 2-12 years in Valencia, Spain, and to analyse its association with key sociodemographic variables. A…

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Negative / Null Result ReportMedicine

Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience.

Heidtmann, Umbreit, Eckoldt · 2026 · Journal of pediatric urology

Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term…

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Negative / Null Result ReportMedicine

Effect of polymerase chain reaction-based antifungal stewardship on candidemia management in small- and medium-sized hospitals.

Miyazaki, Ishigo, Yamada et al. · 2026 · Journal of pharmaceutical health care and sciences

Candidemia has high mortality and requires early antifungal stewardship (AFS). Management by non-infectious disease specialists has been associated with worse outcomes, particularly in small- and medium-sized hospitals where infectious…

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Negative / Null Result ReportMedicine

The cortisol awakening response (CAR) of elite athletes is elevated before a competition, but no interaction with sport type.

Jiménez, Lopez-Lluch, Barón-López et al. · 2026 · Psychoneuroendocrinology

The cortisol awakening response (CAR) is thought to represent an anticipatory mechanism to prepare for upcoming demands. In sport, competition increases in the CAR have been reported, although findings remain inconsistent. A study on…

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Negative / Null Result ReportOpen accessMedicine

Study preregistration: an early example and analysis.

Wiseman R, Watt C · 2026 · PeerJ

Preregistration is commonly seen as an effective way of reducing questionable research practices within psychology. This procedure happens prior to data collection/analysis and usually involves either sending in a research plan to a study…

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Negative / Null Result ReportMedicine

Uncharted Waters: Effects of Maritime Emission Regulation.

Hansen-Lewis J, Marcus M · 2025 · American economic journal. Economic policy

Maritime shipping emits as much fine particulate matter as half of global road traffic. We are the first to measure the consequences of US maritime emissions standards on air quality, human health, racial exposure disparities, and…

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Negative / Null Result ReportMedicine

On the Accuracy of Replication Failure Rates.

Schauer JM · 2023 · Multivariate behavioral research

A prominent approach to studying the replication crisis has been to conduct replications of several different scientific findings as part of the same research effort. The reported proportion of findings that these programs determined…

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Negative / Null Result ReportMedicine

Amuc_1100 alleviates HFD-induced hepatic lipid accumulation via gut microbiota in zebrafish: insights from the role of intestinal 14-3-3β/α-A.

Ding, Lou, Liang et al. · 2026 · Journal of animal science and biotechnology

Amuc_1100, the most abundant outer membrane protein of Akkermansia muciniphila, alleviates high-fat diet (HFD)-induced hepatic lipid accumulation and modulates gut microbiota in fish; however, its mechanism and mediators remain unknown.…

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Negative / Null Result ReportMedicine

Diagnostic accuracy of tuning fork weber test and audiometric weber test in school-aged children with conductive hearing loss.

Peng, Nik Othman, Zakaria et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

While the application of tuning fork Weber (TFW) test in adult is well-documented, its accuracy in the paediatric population remains uncertain although conductive hearing loss is frequently identified in children. Similarly, the…

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Negative / Null Result ReportMedicine

Effect of build orientation, sintering schedule, and resin cement on the bond strength of additively manufactured zirconia to dentin.

Sabatini, Molinero-Mourelle, Limones et al. · 2026 · The Journal of prosthetic dentistry

Whether the manufacturing protocol (build orientation and sintering schedule) of additively manufactured (AM) zirconia impacts the bond strength compared with subtractively manufactured (SM) zirconia remains unclear. The purpose of this in…

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Failed Experiment ReportMedicine

[Prokaryotic expression of Echinococcus granulosus Polo-like kinase 2 and immunoprotective efficacy of its recombinant protein].

Wang, Yan, Qi et al. · 2026 · Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

To prepare the recombinant Echinococcus granulosus Polo-like kinase 2 (rEgPLK2) protein and evaluate its immunoprotective efficacy against cystic echinococcosis, so as to provide insights into research and development of novel vaccines…

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Negative / Null Result ReportMedicine

Effect of sleep quality on physical performance in the elderly.

Roy, Jahagirdar, Kumar et al. · 2026 · Journal of bodywork and movement therapies

Deteriorating physical performance with ageing increases the risk of falls, loss of independence, institutionalisation and mortality amongst elderly. Apart from multisystem body decline, poor quality sleep, being a common complaint amongst…

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Negative / Null Result ReportMedicine

Effect of Inulin-Type Fructans on Body Composition, Carbohydrate Metabolism and Energy Expenditure in Patients with Psoriasis: Results of INGUTSKIN Randomized Controlled Trial.

Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients

Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…

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