Overall Survival With First-Line vs Second-Line CDK4/6 Inhibitor Use in Advanced Breast Cancer
Noor Wortelboer; Annemiek van Ommen-Nijhof; Inge R. Konings; Vincent van der Noort; E. van den Pol; Cristina Guerrero Páez; Sandra D. Bakker; Sjoerd Hovenga · 2026 · JAMA Oncology
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Importance: Cyclin-dependent kinase (CDK) 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy are widely used in hormone receptor (HR)-positive, ERBB2-negative advanced breast cancer (ABC). The SONIA trial evaluates the optimal…
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Metadata source: OpenAlex · DOI 10.1001/jamaoncol.2025.6585