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Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Prenatal and adolescent exposure to metals/metalloids and telomere dynamics at 14 years: Evidence from the Chitwan birth cohort.

Wai KM, Parajuli RP, Umezaki M · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Telomeres are repetitive non-coding DNA sequences at chromosome ends that progressively shorten with each cell division, serving as markers of cellular aging. Recent studies have suggested that prenatal and postnatal exposure to…

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Replication FailureMedicine

Eating your emotions: Within-person relations of emotional overeating with lability/negativity and emotion regulation from childhood to young adulthood.

Parisi F, Steinsbekk S, Wichstrøm L et al. · 2026 · Child development

Emotional overeating theories posit that lability/negativity and poor emotion regulation increase emotional overeating risk, yet empirical evidence is limited. This longitudinal study followed 878 Norwegian participants (50.1% girls)…

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Negative / Null Result ReportMedicine

Loneliness and somatic complaints: An experience sampling method study.

Smeets M, Hutten E, Verboon P et al. · 2026 · Journal of psychosomatic research

Objective Previous studies have shown a positive relation between retrospectively measured loneliness and somatic complaints. This study investigated the relation between state loneliness and state somatic complaints as well as the…

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Negative / Null Result ReportMedicine

Impact of Septal Deviation and Sinonasal Variations on Nasolacrimal Duct Obstruction in PANDO and Chronic Dacryocystitis: A CT-Based Study.

Dikici O, Aslanci ME, Alkan İ · 2026 · Ear, nose, & throat journal

ObjectiveTo assess the relationship between nasal septal deviation characteristics, sinonasal variations, and nasolacrimal duct (NLD) obstruction in primary Acquired Nasolacrimal Duct Obstruction (PANDO) and chronic dacryocystitis.MethodsA…

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Negative / Null Result ReportMedicine

Associations Between Depression and Problematic Social Media Use: A Longitudinal Study and Daily Diary Study.

Yuan C, Zhou H, Wang A et al. · 2026 · International journal of psychology : Journal international de psychologie

Depression is frequently associated with problematic social media use (PSMU), yet evidence integrating day-to-day dynamics with longer-term temporal ordering remains limited. We conducted two studies to examine these associations. In Study…

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Negative / Null Result ReportMedicine

Posttraumatic cognitions and PTSD symptom change in massed prolonged exposure: The impact of treatment delivery on mechanisms of change.

Burton M, Haft S, Fiskeaux M et al. · 2026 · Journal of anxiety disorders

Background Prolonged Exposure (PE) is an effective treatment for PTSD and clarification of mechanisms of change can inform training and continued improvements. Posttraumatic cognitions have been shown to predict subsequent symptom change…

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Negative / Null Result ReportMedicine

Associations among maternal prenatal depression, maternal autism traits, and child autism traits in the Environmental Influences on Child Health Outcome (ECHO) program.

Nutor C, Dunlop AL, Brennan PA · 2026 · Journal of neurodevelopmental disorders

Background Maternal depression during pregnancy has been associated with increased risk of offspring autism spectrum disorder (ASD) - a highly heritable neurodevelopmental disorder. However, no study to date has taken into account maternal…

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Negative / Null Result ReportMedicine

A simple clinical risk score can predict frailty in HNSCC patients.

Kunz V, Wald T, Gaenzle M et al. · 2026 · Cancer treatment and research communications

Introduction Frailty is a predictor of adverse outcomes in cancer patients, but its assessment in head and neck squamous cell carcinoma (HNSCC) patients is often limited due to time-consuming questionnaires being required for comprehensive…

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Negative / Null Result ReportMedicine

Development of a new disseminated intravascular coagulation score tailored for patients with chronic liver disease: a prospective observational study.

Scarlatescu E, Lisman T · 2026 · Journal of thrombosis and haemostasis : JTH

Background Diagnosing disseminated intravascular coagulation (DIC) in patients with chronic liver disease is challenging because cirrhosis-related hemostatic abnormalities mimic DIC laboratory features, leading to frequent overdiagnosis…

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Negative / Null Result ReportMedicine

Genetic and Environmental Associations Between Processing Speed and Executive Functions Across Adolescence and Established Adulthood.

Karhadkar MA, Friedman NP, Reynolds CA et al. · 2026 · Behavior genetics

Processing speed (PS), the rate at which an individual can perform basic cognitive tasks, and executive functions (EFs), cognitive abilities regulating thoughts and action, are key cognitive abilities related to important life outcomes. We…

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