12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Edward I. Chang, Hong Zhang, Jun Liu et al. · 2015 · Head & Neck
BACKGROUND: Risk factors and techniques for free flap salvage in head and neck reconstruction are poorly described. METHODS: We conducted a retrospective review of all head and neck free flaps performed from 2000 to 2010. RESULTS: Overall,…
View details →Marco Marklewitz, Florian Zirkel, Innocent B. Rwego et al. · 2013 · Journal of Virology
Bunyaviruses are the largest known family of RNA viruses, infecting vertebrates, insects, and plants. Here we isolated three novel bunyaviruses from mosquitoes sampled in Côte d'Ivoire, Ghana, and Uganda. The viruses define a highly…
View details →Sanjib Mohanty, Saroj K. Mishra, Rajyabardhan Patnaik et al. · 2011 · Clinical Infectious Diseases
BACKGROUND: Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is…
View details →Shujing Chen, Dingyu Zhang, Tianqi Zheng et al. · 2020 · Journal of Thrombosis and Thrombolysis
Few data are available on the incidence of deep vein thrombosis (DVT) in critically ill COVID-19 with thrombosis prophylaxis. This study retrospectively included 88 patients in the ICU with critically ill COVID-19 at Jinyintan Hospital in Wuhan, China. All patients underwent compression ultrasonography for identifying DVT. Firth logistic regression was used to examine the association of DVT with sex, age, hypoalbuminemia, D-dimer, and SOFA score. The median (interquartile range [IQR]) age and SOFA score of 88 patients were 63 (55-71) years old and 5 (4-6), respectively. Despite all patients re
View details →Marc A. Judson, Kristin B. Highland, Soon-Ho Kwon et al. · 2011 · PubMed
BACKGROUND: Sarcoidosis associated pulmonary hypertension (SAPH) is associated with significant morbidity and mortality. There is a paucity of information concerning therapy for this condition. METHODS: We performed a prospective,…
View details →Hung-Yu Liu, Kun‐Hsien Chou, Pei‐Lin Lee et al. · 2016 · Cephalalgia
Objectives To investigate the structural changes of hippocampus and amygdala and their relationships with migraine frequency and prognosis. Methods Hippocampus and amygdala volumes were measured by 3-T brain magnetic resonance imaging…
View details →Ashfaq Shuaib, Natan M. Bornstein, Hans‐Christoph Diener et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Fewer than 5% of patients with acute ischemic stroke are currently treated, and there is need for additional treatment options. A novel catheter treatment (NeuroFlo) that increases cerebral blood flow was tested to…
View details →N. de Korte, Johan P. Kuyvenhoven, Donald L. van der Peet et al. · 2011 · Colorectal Disease
AIM: Conservative treatment of mild colonic diverticulitis usually consists of observation, restriction of oral intake, intravenous fluids and antibiotics. The beneficiary effect of antibiotics remains unclear. The aim of this study is to…
View details →David Gaist, Ellen Garde, Morten Blaabjerg et al. · 2016 · Brain
A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of…
View details →Jason R. Conn, Elizabeth Catchpoole, Naomi Runnegar et al. · 2017 · PLoS ONE
Febrile neutropenia (FN) is a medical emergency and can represent a life-threatening complication for hematology patients treated with intensive chemotherapy regimens. In clinical practice, the diagnostic yield of blood cultures and other investigations which aim to identify a causative organism or site of infection is low. We have retrospectively examined all blood cultures collected in a "real world" cohort of patients receiving chemotherapy for acute leukemia and patients with aggressive lymphoma treated with Hyper-CVAD/MTX-cytarabine, at a single tertiary center over a five-year period. In
View details →Marie Louise Tørring, Peter Murchie, William Hamilton et al. · 2017 · British Journal of Cancer
BACKGROUND: The benefits from expedited diagnosis of symptomatic cancer are uncertain. We aimed to analyse the relationship between stage of colorectal cancer (CRC) and the primary and specialist care components of the diagnostic interval.…
View details →Manesh R. Patel, Richard C. Becker, Daniel Wojdyla et al. · 2014 · European Journal of Preventive Cardiology
AIMS: To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS: PLATO (n = 18,624) was a multicentre, double-blind, randomized…
View details →Patrick J. Leavey, Nadia N. Laack, Mark D. Krailo et al. · 2021 · Journal of Clinical Oncology
PURPOSE The primary aim of this phase III randomized trial was to test whether the addition of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed chemotherapy improved survival outcomes for patients with previously…
View details →Wendy Y. Craig, Walter C. Allan, Edward M. Kloza et al. · 2011 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Lower neurocognitive development scores at age 2 yr have been reported in association with euthyroid hypothyroxinemia during early pregnancy. OBJECTIVE: The objective of this study was to further explore this association with…
View details →Thomas Tu, William S. Mason, Andrew D. Clouston et al. · 2015 · Journal of Viral Hepatitis
Hepatocyte clone size was measured in liver samples of 21 patients in various stages of chronic hepatitis B virus (HBV) infection and from 21 to 76 years of age. Hepatocyte clones containing unique virus-cell DNA junctions formed by the…
View details →Gianluca Tognon, Lauren Lissner, Ditte Sæbye et al. · 2013 · British Journal Of Nutrition
The aim of the present study was to determine whether the Mediterranean Diet Score (MDS) is associated with reduced total mortality, cardiovascular incidence and mortality in a Danish population. Analyses were performed on 1849 men and…
View details →Anahita Mostaghim, Hoi Yee Annie Lo, N.M. Khardori · 2017 · SAGE Open Medicine
Objective: This study aims to define risk factors as well as their association with microbiology and clinical outcomes in a large US infective endocarditis population. Methods: Hospital records were searched for appropriate infective…
View details →Danielle S. Gruen, Joshua B. Brown, Francis X. Guyette et al. · 2020 · JCI Insight
BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomark
View details →Tina Wong, Lei Zhou, Jing Li et al. · 2011 · Investigative Ophthalmology & Visual Science
PURPOSE: To identify the tear proteins associated with the long-term use of glaucoma medication by using proteomic analysis and to compare these proteins to those previously reported in primary dry eye disease. METHODS: Eighteen patients…
View details →Nuala J. Meyer, John P. Reilly, Brian J. Anderson et al. · 2017 · Critical Care Medicine
OBJECTIVE: Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in randomized trials. We tested for heterogeneity in the treatment effect of recombinant…
View details →Ho‐Chang Kuo, Kuender D. Yang, Suh‐Hang Hank Juo et al. · 2011 · PLoS ONE
Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese pop
View details →Angela Dalia Ricci, Alessandro Rizzo, Fabiola Lorena Rojas Llimpe et al. · 2021 · Cancers
Human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in approximately 15–20% of gastric adenocarcinoma (GC) patients. In 2010, the landmark ToGA trial established the combination of trastuzumab plus chemotherapy as the first-line standard of care for HER2-positive GC patients with advanced disease. However, subsequent studies on HER2 targeted therapies in this setting failed to meet their primary endpoints, and not all HER2-positive GC patients benefit from targeted approaches. More recently, novel HER2-directed treatments have been investigated, including trastuzu
View details →Els M. Gielis, Kristien J. Ledeganck, Amélie Dendooven et al. · 2019 · Nephrology Dialysis Transplantation
BACKGROUND: After transplantation, cell-free deoxyribonucleic acid (DNA) derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to investigate the role of plasma ddcfDNA as biomarker for acute…
View details →John Colin Boyd, Craig A. Simpson, Mary E. Jung et al. · 2013 · PLoS ONE
OBJECTIVE: The purpose of this research was to determine if the adaptations to high intensity interval training (HIT) are mitigated when both intensity and training volume (i.e. exercise energy expenditure) are reduced. METHODS: 19 overweight/obese, sedentary males (Age: 22.7±3.9 yrs, Body Mass Index: 31.4±2.6 kg/m(2), Waist Circumference: 106.5±6.6 cm) performed 9 sessions of interval training using a 1-min on, 1-min off protocol on a cycle ergometer over three weeks at either 70% (LO) or 100% (HI) peak work rate. RESULTS: Cytochrome oxidase I protein content, cytochrome oxidase IV protein co
View details →Katarzyna Dziopa, Folkert W. Asselbergs, Jasmine Gratton et al. · 2022 · Diabetologia
AIMS/HYPOTHESIS: We aimed to compare the performance of risk prediction scores for CVD (i.e., coronary heart disease and stroke), and a broader definition of CVD including atrial fibrillation and heart failure (CVD+), in individuals with type 2 diabetes. METHODS: Scores were identified through a literature review and were included irrespective of the type of predicted cardiovascular outcome or the inclusion of individuals with type 2 diabetes. Performance was assessed in a contemporary, representative sample of 168,871 UK-based individuals with type 2 diabetes (age ≥18 years without pre-existi
View details →P. Rizzo, Emanuela Raffone, Vincenzo Di Benedetto · 2010 · PubMed
OBJECTIVE: The aim of the study was to evaluate the efficacy of a treatment with myo-inositol plus folic acid plus melatonin compared with myo-inositol plus folic acid alone on oocyte quality in women underwent in vitro fertilization (IVF)…
View details →Heidrun H. Krämer, T. Eberle, Nurcan Üçeyler et al. · 2010 · Pain
Posttraumatic TNF-alpha signaling may be one of the factors responsible for pain and hyperalgesia in complex regional pain syndromes (CRPS). In order to further specify the role of TNF-alpha we investigated tissue (skin) and serum…
View details →Taranum Ruba Siddiqui, Saima Ghazal, Safia Bibi et al. · 2016 · PLoS neglected tropical diseases
BACKGROUND: Prevention is most effective in reducing dengue infection risk, especially in endemic countries like Pakistan. Evaluation of public awareness and health beliefs regarding dengue fever (DF) is important for devising disease control strategies. This study assessed dengue knowledge, health beliefs, and preventive practices against DF in different socioeconomic groups of Karachi, Pakistan. METHODOLOGY: In this community-based cross-sectional study, 6 randomly selected towns were visited, 2 persons (man and woman) per household were interviewed using a structured questionnaire, and hous
View details →Romy M. Heilmann, Nora Berghoff, Joanne Mansell et al. · 2018 · Journal of Veterinary Internal Medicine
BACKGROUND: Calprotectin is a marker of inflammation, but its clinical utility in dogs with chronic inflammatory enteropathies (CIE) is unknown. OBJECTIVE: Evaluation of fecal calprotectin in dogs with biopsy-confirmed CIE. ANIMALS: 127…
View details →Zoya Kuzmina, Hildegard Greinix, Roman Weigl et al. · 2010 · Blood
Manifestations of chronic graft-versus-host disease (cGVHD) can resemble those seen in immunodeficiency states and autoimmune disorders. Reports by us and others suggest an involvement of B cells in the pathogenesis of cGVHD. We…
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