Prehospital plasma is associated with distinct biomarker expression following injury
Danielle S. Gruen; Joshua B. Brown; Francis X. Guyette; Yoram Vodovotz; Pär I. Johansson; Jakob Stensballe; Derek Barclay; Jinling Yin · 2020 · JCI Insight
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomark
Abstract by Danielle S. Gruen; Joshua B. Brown; Francis X. Guyette; Yoram Vodovotz; Pär I. Johansson; Jakob Stensballe; Derek Barclay; Jinling Yin, JCI Insight (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1172/jci.insight.135350