12,246 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Fan J, Zeng J, Li H · 2026 · Research in developmental disabilities
Background/aims Children with autism spectrum disorder (ASD) often experience conversational difficulties that hinder social interactions and peer relationships. This study examined whether a conversational AI-enhanced peer-mediated…
View details →Zheng, Jia, Jing et al. · 2026 · International journal of cancer
This single-center retrospective study evaluated radiation pneumonitis (RP) in 209 treatment-naive EGFR-mutant non-small cell lung cancer (NSCLC) patients receiving first-line third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)…
View details →Ng Fat, West, E Jackson · 2026 · BMJ public health
Stopping tobacco smoking, reducing alcohol consumption from high-risk levels, increasing physical activity and improving diet can improve mental well-being. To gain a preliminary estimate of the potential benefits of healthy lifestyle…
View details →Karlsson, Ekendahl, Lindner · 2026 · Child and adolescent psychiatry and mental health
Individuals with substance use problems have higher mortality risks than the general population. This study aimed to assess all-cause and specific-cause mortality among adolescents and young adults in specialized substance use treatment in…
View details →Harmantepe, Canturk, Küçük et al. · 2026 · BMC surgery
Low anterior resection syndrome (LARS) is a frequent functional disorder following sphincter-preserving surgery for rectal cancer. This study aimed to assess the impact of surgical approach and anastomosis distance on LARS development. We…
View details →Lin, Cheng, Chen et al. · 2026 · Avian pathology : journal of the W.V.P.A
Abstract To enable differential detection of virulent and attenuated strains of duck short beak and dwarfism syndrome virus (SBDSV), we developed a fluorescent quantitative PCR (qPCR) assay based on locked nucleic acid (LNA)-TaqMan probes.…
View details →Sun, Li, Li et al. · 2026 · Journal of food science
Lead (Pb) exposure is a major environmental risk factor for cognitive impairment. This effect is mainly caused by oxidative stress, mitochondrial dysfunction in the hippocampus, and neuronal apoptosis. This study examined whether black…
View details →Manca, Paulus, Almeida et al. · 2026 · Neuroscience
Social connectedness strongly influences health and longevity, and adult pair bonds provide psychological benefits distinct from other social relationships. Oxytocin (OT), corticotropin-releasing hormone (CRH), and opioids play an…
View details →Ertürkmen Aru, Büke, Saat et al. · 2026 · Familial cancer
Biallelic loss-of-function variants in NTHL1 are associated with an autosomal recessive cancer predisposition syndrome, whereas the cancer risk associated with monoallelic NTHL1 variants remains uncertain. The recurrent truncating variant…
View details →Fiorenza, Millot, Lecomte et al. · 2026 · The Journal of antimicrobial chemotherapy
Prosthetic joint infections (PJI) of the hip and knee are most often caused by Staphylococcus spp. and require long-term treatment with rifampicin and fluoroquinolone as first-line treatment. However, resistance, contraindications or…
View details →Kobayashi, Yabuki, Sugiyama et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveNo studies have examined the effectiveness of platelet-rich plasma (PRP) alone and platelet-rich fibrin (PRF) without alveolar bone grafting or other bone substitutes for alveolar cleft repair during infancy. This study evaluated…
View details →Sulciner, Wang, Fairweather et al. · 2026 · Cureus
ON-Q pumps, or surgically placed wound catheters, provide analgesia without the side effects of epidural catheters. This study aimed to evaluate perioperative outcomes, including total postoperative oral morphine milligram equivalents…
View details →Sæther, Butt, Eubank et al. · 2026 · Frontiers in psychology
Psychological stressors have become a natural part of the process of developing skills in talent development environments of youth athletes. However, there is little research on psychological stressors among talented female athletes and…
View details →Jamei-Martel, Garibaldi, Castroviejo Fernández et al. · 2026 · JSES international
The optimal management of high-grade acromioclavicular (AC) joint dislocations remains controversial. While surgical treatment improves radiographic alignment, its impact on functional outcomes remains debated. This study prospectively…
View details →Huang, Yin, Lin · 2026 · Transplantation proceedings
The utilization of hepatitis B surface antigen-positive (HBsAg+) living kidney donors is a strategy to expand the donor pool. However, concerns regarding their renal safety after nephrectomy persist due to the potential impact of chronic…
View details →Foster, Millist, Germaine et al. · 2026 · Epilepsia open
ES-481 is a novel potent and selective antagonist of TARP-y8-dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES-481 as an add-on anti-seizure…
View details →Ucan Gunduz, Nizam Tekcan, Erdem et al. · 2026 · Journal of pediatric ophthalmology and strabismus
To investigate microstructural alterations in the retina, choroid, and optic nerve head in children with spina bifida using optical coherence tomography. Thirty-eight children with spina bifida and 32 children without spina bifida were…
View details →Zamaniyan, Abbasi, Habibpour et al. · 2026 · International journal of reproductive biomedicine
Diminished ovarian reserve is one of the most important issues in in vitro fertilization cycles. Some authors have reported beneficial effects of dual triggering in women with poor ovarian response, whereas other investigators have…
View details →Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia
Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…
View details →Alencar, Teles, Cunha et al. · 2026 · Revista brasileira de ortopedia
Artificial intelligence (AI) tools based on natural language, such as ChatGPT 4.1 mini (OpenAI Group PBC) and Gemini 2.5 Flash (Alphabet Inc.), are used by patients as sources of medical information. The current study aimed to evaluate and…
View details →Petrina, Dong, Beamer et al. · 2026 · Open forum infectious diseases
Vaginal dysbiosis is associated with HIV acquisition and preterm delivery. Our objective was to evaluate prevalent vaginal infections, and changes in microbiota and cytokines among pregnant and breastfeeding women from 4 African countries…
View details →Hardika, Kurniawan, Laksmi et al. · 2026 · Journal of the ASEAN Federation of Endocrine Societies
Leukocyte telomere length (LTL) is considered a biomarker of cellular senescence. Previous studies have reported the associations between shortened telomere length and type 2 diabetes mellitus (T2DM). However, the role of underlying…
View details →Durgala, Horvath, Skrabanova et al. · 2026 · Frontiers in behavioral neuroscience
Traumatic brain injury (TBI) is a major health concern in the current population. Animal models are increasingly important for identifying early neurobehavioural changes associated with mild to severe as well as repetitive brain injuries.…
View details →Choi, Park, Song et al. · 2026 · Psychiatry investigation
Although its potential antidepressant effects have been suggested, evidence on long-term outcomes for post-delivery depression remains limited. We evaluated whether peripartum intravenous magnesium sulfate (MgSO₄) is associated with…
View details →Lamb, Akulian, Musani et al. · 2026 · Respiratory research
Single chain urokinase (LTI-01) intrapleural enzymatic therapy (IET) was safe and promising in a phase 1 clinical trial to overcome failed drainage in patients with pleural infection. The LTI-01-2001 phase 2a trial was a randomized,…
View details →Akdogan, Aydin · 2026 · BMC oral health
Data comparing the wear of 3D printed permanent resin (PR) and milled zirconia (Z) to that of primary tooth enamel are limited. This study aimed to investigate the wear behavior of two materials and their effect on antagonist primary…
View details →Güler, Kaplan, Şahan et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses
Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies…
View details →Russo, Comune, Di Nardo et al. · 2026 · International journal of cardiology
The shortened protocol of Nitroglycerin (NTG)-potentiated head-up tilt testing (HUTT), the so-called "fast Italian protocol," has been shown to significantly reduce test duration while maintaining diagnostic yield and safety in adults with…
View details →Yeh, Ahuja, Patel et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
We conducted a target trial emulation study to examine the effect of two glucagon-like peptide-1 receptor agonists (GLP1RAs) (semaglutide and tirzepatide) on clinical outcomes in patients with inflammatory bowel diseases (IBD) with obesity…
View details →Jyung, Sun, Li et al. · 2026 · Journal of pain and symptom management
Pain catastrophizing (PC) predicts worse pain outcomes in cancer survivors. However, little is known whether PC influences pain outcomes of non-pharmacological treatments such as acupuncture. This study aimed to assess the impact of PC on…
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