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Browse the failure-mode index

12,246 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus.

Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…

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Negative / Null Result ReportOpen accessMedicine

Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression.

Sakreida K, Trapp NT, Kreuzer S et al. · 2025 · BMJ mental health

Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising…

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Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

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Failed Experiment ReportMedicine

Morphea after Silicone Implants.

Wollina U, Schönlebe J · 2023 · Acta dermatovenerologica Croatica : ADC

Dear Editor, Silicone is a hydrophobic polymer containing silicon. Silicon is an essential compound of soft tissue proteoglycans. Reports about morphea and other autoimmune connective tissue disorders in association with silicone implants…

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Failed Experiment ReportMedicine

Seeing color following gene augmentation therapy in achromatopsia.

McKyton A, Marks Ohana D, Nahmany E et al. · 2023 · Current biology : CB

How will people who spent their visual lives with only rods respond to cone function restoration? Will they be able suddenly see the colors of the rainbow? CNGA3-achromatopsia is a congenital hereditary disease in which cone dysfunction…

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Negative / Null Result ReportMedicine

The distribution of the Lansing Effect across animal species.

Ivimey-Cook ER, Shorr S, Moorad JA · 2023 · Evolution; international journal of organic evolution

Maternal senescence is the reduction in individual performance associated with increased maternal age at conception. When manifested on adult lifespan, this phenomenon is known as the "Lansing Effect." Single-species studies report both…

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Negative / Null Result ReportOpen accessMedicine

An Exploratory Analysis of Essential Tremor and Associated Phenotypes.

Gharibian D, Medeiros M, Dion PA et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Essential Tremor (ET) is a highly heterogeneous movement disorder with a strong genetic basis. However, the etiology of ET is unclear, largely due to its clinical heterogeneity and frequently observed comorbidities. We conducted a…

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Negative / Null Result ReportMedicine

New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.

Heneghan JA, Akande MY, Ramgopal S et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe change in Functional Status Scale (FSS) associated with critical illness and assess associated development of new morbidities with PICU readmission. Design Retrospective, cross-sectional cohort study using the…

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Negative / Null Result ReportOpen accessMedicine

Optimal time between decompressive craniectomy and cranioplasty to reduce the risk of complications: A retrospective study.

Stretti F, Parvin R, Fariña Nuñez MT et al. · 2026 · Neurosurgical review

Cranioplasty (CP) is performed after decompressive craniectomy (DC), with complication rates of 15-40%. Risk factors and ideal timing for CP are unclear. This study investigates risk factors for complications after CP and the best time to…

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Negative / Null Result ReportMedicine

Is variability in working memory capacity related to differences in the reactivation of memory traces? A test based on the time-based resource sharing (TBRS) model.

Gonthier C, Gavornikova-Baligand Z · 2023 · Attention, perception & psychophysics

Working memory performance depends on reactivating memory traces, by rapidly switching between refreshing item representations and performing concurrent cognitive processing (time-based resource sharing (TBRS) account). Prior research has…

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Negative / Null Result ReportOpen accessMedicine

Does the airway circulation influence airflow obstruction in asthma?

Wanner A · 2025 · BMJ open respiratory research

The airway wall is thickened in asthma and the airway microvasculature participates in the remodelling. It has been assumed but not convincingly demonstrated that the remodelled airway vasculature has a mechanical role in asthma-associated…

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Negative / Null Result ReportOpen accessMedicine

The Impact of GLP-1 Receptor Agonists on Esophagogastroduodenoscopy Outcomes: A Retrospective Cohort Study in a Predominantly African American Population.

El Sabagh A, Abdulraheem A, Jimenez A et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control and promote weight loss but may increase gastric residue, raising concerns during esophagogastroduodenoscopy (EGD). African American patients remain…

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Negative / Null Result ReportOpen accessMedicine

Impact of a Mindfulness-Based Intervention on Symptoms and Emotion Regulation Strategies in Young Adolescents From the General Population: A Randomized Controlled Trial.

Piguet C, Celen Z, Meuleman B et al. · 2025 · Depression and anxiety

Adolescence is marked by major puberty-induced changes including increased reactivity to stress and a peak incidence of mental disorders. The implementation of early interventions during this developmental period is essential to prevent…

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