Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential
Gilliana Rozenblum; Karima Ait‐Aissa; G. E. D. Zahran; Mahdieh Alipour; Amal M. Sahyoun; Undral Munkhsaikhan; Adam Kassan; Tauheed Ishrat · 2025 · Alzheimer s & Dementia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and Neisseria spp. impairs anti-inflammatory protection, worsening neuronal damage. P. gingivalis is strongly linked to an increased risk of AD, especially in individuals with systemic conditions like diabetes, hypertension, and chronic kidney disease. Its presence
Abstract by Gilliana Rozenblum; Karima Ait‐Aissa; G. E. D. Zahran; Mahdieh Alipour; Amal M. Sahyoun; Undral Munkhsaikhan; Adam Kassan; Tauheed Ishrat, Alzheimer s & Dementia (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/alz.71011