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Browse the failure-mode index

21,778 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Putting the testing effect to the test in the wild: Retrieval enhances real-world memories and promotes their semantic integration while preserving episodic integrity

Homann LA, Jahed M, Barense M · 2025 · Preprint

Retrieval practice—actively recalling information—is an established memory-strengthening technique. However, understanding how retrieval transforms memory requires examining its effects on memories that evolve across multiple episodic and…

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Negative / Null Result Report

Putting the testing effect to the test in the wild: Retrieval enhances real-world memories and promotes their semantic integration while preserving episodic integrity

Homann LA, Jahed M, Barense M · 2025 · Preprint

Retrieval practice—actively recalling information—is an established memory-strengthening technique. However, understanding how retrieval transforms memory requires examining its effects on memories that evolve across multiple episodic and…

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Negative / Null Result ReportMedicine

Effects of Combined Intragastric Administration of Quinine with L-Leucine or L-Isoleucine on the Glycemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Healthy Males.

Sajjad M, Ghorbaninejad P, Bitarafan V et al. · 2026 · The Journal of nutrition

Background The amino acids, L-leucine (Leu) and L-isoleucine (Ile), and the bitter substance, quinine, reduce postprandial glucose, stimulate insulin, and/or slow gastric emptying. Whether combining these stimuli can enhance these effects…

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Negative / Null Result ReportMedicine

Antileishmanial Activity of Oseltamivir and Acyclovir: Modulation of Macrophage Phagocytosis and Cytotoxicity Assessment.

Lima Neta PP, Leal PPMS, Passos VHAA et al. · 2025 · Anais da Academia Brasileira de Ciencias

Leishmaniasis is a group of diseases caused by protozoa of the genus Leishmania . Current treatments exhibit high toxicity, high costs, and parasite resistance. Consequently, the search for new drugs is of utmost importance, and drug…

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Negative / Null Result ReportMedicine

Comparative Analysis of Intrathecal Lidocaine Combined With Guanfacine or Dexmedetomidine on Nociceptive and Motor Blockade in Rats.

Chou AK, Chiu CC, Chen YW et al. · 2025 · Fundamental & clinical pharmacology

The aim of this study was to examine the effects of intrathecal lidocaine combined with guanfacine or dexmedetomidine on nociceptive and motor blockade, in comparison to clonidine. Using a rat model of intrathecal injection, we evaluated…

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Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and Biophysical Research Communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

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Negative / Null Result ReportMedicine

Reevaluating diagnostic confidence: the impact of delayed excretory phase imaging in CT urography on detecting renal and urinary tract abnormalities.

Firoozeh N, Park SY, Basavalingu D et al. · 2026 · Abdominal radiology (New York)

Objective To assess the diagnostic value of the delayed excretory phase in computed tomography urography (CTU) for detecting renal and urinary tract abnormalities and its impact on readers' confidence in patients with hematuria, given…

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Negative / Null Result ReportMedicine

Commercial cytokine assay on equine cerebrospinal fluid does not distinguish equine degenerative myeloencephalopathy from cervical vertebral stenotic myelopathy.

Payette F, Kulp JC, Graves A et al. · 2025 · American journal of veterinary research

Objective To measure and compare CSF cytokine concentrations among horses with equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM), horses with cervical vertebral stenotic myelopathy (CVSM), and control horses…

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Negative / Null Result ReportMedicine

Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial.

Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…

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Negative / Null Result ReportMedicine

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.

Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis

Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…

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Negative / Null Result ReportMedicine

Revisiting NaOH Addition during the Amination of Cellulose Nanocrystals.

Clouse DE, Collins EG, Khodakovskaya MV et al. · 2025 · Biomacromolecules

There is growing recognition that both cellulose nanocrystal (CNC) source and production scheme affect their physicochemical properties and dispersion behavior. However, how these differences affect CNC surface chemistry modification has…

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Negative / Null Result Report

Orange (Citrus sinensis) essential oil as feed additive for sheep: nutrient intake and apparent digestibility, nitrogen balance, and rumen fermentation characteristics

Junior PCGD, Vicente ACS, Santos IJd et al. · 2025 · Preprint

Abstract The study evaluated the effects of orange essential oil (OEO) as a feed additive on nutrient intake, digestibility, nitrogen balance, and rumen fermentation in meat sheep. Using ten rumen-cannulated Dorper × Santa Inês wethers in…

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Negative / Null Result ReportMedicine

Open- source computed tomography (CT)-based sarcopenia assessment in women with suspicious adnexal masses: a feasibility and reproducibility study.

Badran PM, Stecca CM, de Souza de Castro JT et al. · 2025 · Clinical radiology

Aim Ovarian cancer is the most lethal gynecologic malignancy, with prognosis linked to stage at diagnosis. Ultrasonography is the first-line tool for adnexal mass evaluation, while computed tomography (CT) supports staging and surgical…

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Negative / Null Result ReportMedicine

Effects of Zinc oxide nanoparticles on llama sperm cryopreservation.

di Fonzo AR, Bertuzzi ML, Amusquibar MV et al. · 2025 · Animal reproduction science

Zinc oxide nanoparticles (ZnO-NPs) have been reported to enhance sperm cryopreservation in several species, but their effect on frozen llama semen remains unexplored. This study aims to evaluate the effect of ZnO-NPs on sperm parameters in…

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Negative / Null Result ReportOpen accessMedicine

Performance of the Self-Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using Merative MarketScan Research Databases.

Coste A, Wong AYS, Haguinet F et al. · 2025 · Pharmacoepidemiology and drug safety

Background Despite testing of epidemiological methods in US Claims databases for signal detection, such data sources have not become a routine capability. The Self Controlled Case Series (SCCS) is one of the most promising methods for drug…

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Negative / Null Result ReportMedicine

Effects of passive information dissemination on human papillomavirus vaccination attitudes and knowledge among pharmacy visitors: A cluster randomized controlled trial.

Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA

Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…

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Negative / Null Result ReportOpen accessMedicine

Subacromial bursa augmentation in arthroscopic rotator cuff repair: Clinical and doppler ultrasound assessment-A preliminary study.

Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics

Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…

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