21,778 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Chusyd DE, Austad SN, Brown JL et al. · 2026 · Preprint
Early-life trauma in humans, including maternal loss, is strongly associated with increased risk of chronic diseases, reduced life expectancy, and accelerated biological aging, as measured through epigenetic modifications, such as DNA…
View details →Neeser HR, Gerwinn T, Forschbach VC et al. · 2026 · Journal of pediatric surgery
Background Children still suffer from substantial pain after laparoscopic surgery. It has been hypothesized that low-pressure pneumoperitoneum reduces postoperative pain after laparoscopic surgery. However, this has not yet been studied in…
View details →Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
View details →Adami A, Vitacca M, Casaburi R et al. · 2026 · European journal of applied physiology
PURPOSE: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic obstructive pulmonary disease (COPD) diagnosed with hypoxemia at rest or during activity. Chronic hypoxemia is a potential mediator of loss of…
View details →Pacheco CFO, Costa RF, Silva AEB et al. · 2026 · Forest Ecology and Management.
Mangroves face increasing threats from human degradation and extreme weather events, yet limited information exists on whether they can naturally recover after those disturbances. In this study, we attempted to fill this gap by assessing…
View details →Antonarakis ES, Antonarakis ES, Cao Q et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This multicenter, single-arm, phase II trial evaluated the safety and efficacy of cabazitaxel and carboplatin followed by abiraterone, plus androgen deprivation therapy (ADT), in patients with high-volume metastatic…
View details →Wanner P, Ostermair F, Cristini J et al. · 2026 · Experimental brain research
A single bout of cardiovascular exercise (CVE) can promote neuroplasticity in an intensity-dependent manner. Consequently, performing CVE immediately after encoding may enhance motor memory consolidation, with stronger effects reported for…
View details →Agarwal N, Rochat P · 2025 · Preprint
Across two experiments, children (N = 259, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
View details →Almeida OP, Page A, Etherton-Beer C · 2026 · International psychogeriatrics
Behavioural and psychological disturbances are common among individuals with dementia. It is unclear if the use of antidementia medicines reduces their presence. This study aimed to clarify if the introduction of antidementia medicines…
View details →Getachew ED, Wronski ML, Van De Water AL et al. · 2026 · The International journal of eating disorders
Objective Avoidant/restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent avoidant/restrictive eating unrelated to body image. Sex differences in clinical phenotypes and neurobiology of ARFID are…
View details →Pohjola A, Asikainen A, Kaprio J et al. · 2026 · Neurology
Background and objectives The growing use and improved accessibility of noninvasive imaging modalities have increased the detection of incidental intracranial findings, such as unruptured brain arteriovenous malformations (AVMs). At the…
View details →Crawford M, Leonardi C, Martin MP et al. · 2026 · Journal of surgical orthopaedic advances
This study sought to characterize patient interest in utilizing telemedicine for orthopaedic surgery clinic visits in a primarily Medicaid population. The authors hypothesized that interest in telemedicine would be associated with higher…
View details →De Laet H, Nijhof A, Wiersema JR · 2025 · Preprint
While prevailing theories suggest social interaction difficulties are inherent to autism, the theory of the double empathy problem (DEP) proposes these difficulties arise from a mismatch between different neurotypes. The theory predicts…
View details →Tröger A, Schneider J, Tsapekos D et al. · 2026 · Preprint
Intro: Many people with bipolar disorder (BD) experience persistent cognitive deficits. Sleep spindles have been linked to cognitive ability in healthy populations and psychotic disorders. While there is preliminary evidence for altered…
View details →Raidl P, Vogl A, Dreisoerner A et al. · 2025 · Preprint
Introduction: Prior evidence suggests that individuals with higher fitness exhibit attenuated endocrine and autonomic responses to acute stress. However, it remains unclear whether this stress-buffering effect depends on the type of…
View details →Lorrimar V, van Mulukom V · 2025 · Preprint
In an era of polycrisis, the philosophy of longtermism posits that positively influencing the long-term future is a key moral priority. This study investigates psychological factors predicting moral concern for future generations, focusing…
View details →Le Blanc-Brillon J, Fortin JS, Lafrance L et al. · 2025 · Frontiers in psychology
Introduction Social networking sites (SNSs) have become an integral part of daily life, raising concerns about their potential impact on mental health. One key mechanism through which SNSs may affect wellbeing is social comparison. The…
View details →Smulligan KL, Lempke LB, Mannix RC et al. · 2026 · The Journal of pediatrics
Objective To investigate whether slower reaction time (RT) was associated with higher concussion odds among middle school female soccer players. Study design We performed a retrospective cohort study, analyzing pre-participation…
View details →De Laet H, Nijhof A, Wiersema JR · 2025 · Preprint
Purpose: Autism is associated with social interaction and communication difficulties. The theory of the double empathy problem challenges the idea that these difficulties are inherent to autism, arguing that they rather stem from a…
View details →Wu R, Jin H, Shen J · 2025 · Preprint
Abstract Despite known benefits in normal diet, capsaicin's effects under obesogenic conditions remain unexplored. Based on capsaicin's established metabolic benefits, we hypothesized that capsaicin supplementation would extend lifespan in…
View details →Clucas K, Saito A · 2026 · The Physician and sportsmedicine
Background Medial elbow injuries occur in approximately one-third of all young baseball players and are characterized by injuries to the bone and cartilaginous growth plates. Bone mineral mass, a representative of bone strength, may show…
View details →Adams R, Deroche MLD · 2025 · The Journal of the Acoustical Society of America
To extract a voice from a background of competing speakers, the human brain exploits voice pitch (harmonic cues) and spatial location (binaural cues) to separate speakers perceptually, and effectively attenuates the background (anything…
View details →LeBlanc MR, Zhou X, Baggett CD et al. · 2026 · Cancer medicine
Background This study aims to describe time to treatment initiation for Black and White older adults with multiple myeloma (MM), and to test the hypothesis that Black/White disparities in treatment initiation have increased over time.…
View details →Ogawa K, Shimatani K, Endo K et al. · 2026 · Public health
Objectives This study examined the association between individual housing cost burden and depressive symptoms, hypothesizing stronger associations particularly in primary breadwinner men who may bear disproportionate financial…
View details →Ruan N, Ng AJ, Christianson JP · 2025 · Preprint
ABSTRACT Competing motivational drives are integral to survival and encompass a spectrum of internal physiological needs such as hunger to external goals like social connection. Elucidating how these motivational states interact at the…
View details →Song J, Pennartz KJ, Caldwell JT et al. · 2026 · European journal of applied physiology
Purpose Near-infrared spectroscopy (NIRS) with vascular occlusion testing (VOT) is used to assess skeletal muscle tissue oxygenation (StO 2 ) responses. Differences in NIRS-VOT outcomes exist between trained and untrained groups; however,…
View details →Kemp LT, Smeets T, Jansen A et al. · 2026 · Journal of behavior therapy and experimental psychiatry
While studying appetitive and aversive conditioning is common in psychopathology research, studies that measure both types of learning simultaneously are rare. To gain insight into the role of appetitive and aversive learning in the…
View details →Del Grosso SJ, Nichols KL, Delgado JA et al. · 2025 · Nutrient cycling in agroecosystems.
Grassland soils managed with livestock grazing can act as sources and sinks for methane (CH₄) and nitrous oxide (N₂O), but, in aggregate, are typically a source of N₂O and a sink for CH₄. Previously, we observed higher N₂O losses from…
View details →Arriero-Cabañero A, Díaz-Rubio N, Talabán-Rocha C et al. · 2025 · Molecular neurobiology
Pyruvate kinases are key enzymes of glycolytic metabolism of neurons and glia. One of them, pyruvate kinase M2 (PKM2) can also act as a transcriptional regulator and in this function has been implicated in several neurodegenerative…
View details →Moreau AL, Rappaport BI, Saturday ML et al. · 2026 · Journal of psychiatric research
Intolerance of uncertainty (IU) is an individual difference dimension reflecting negative cognitive, emotional, and behavioral responses to uncertainty. IU is an important etiological and maintaining mechanism of internalizing…
View details →