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Browse the failure-mode index

21,778 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

How will we find the elephant in the room?

Wybo Houkes, Krist Vaesen · 2020 · Behavioral and Brain Sciences

Abstract We argue that Osirak's and Reynaud's technological-reasoning hypothesis raises conceptual and methodological challenges. Interrelations between technical potential and expertise leave it unclear exactly what the…

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Negative / Null Result ReportMedicine

Clinical characteristics, antithrombotic strategies, and outcomes in patients with atrial fibrillation and coronary heart disease undergoing percutaneous coronary intervention: a multicenter real-world study in Chongqing, China.

Bao, Wu, Li et al. · 2026 · BMC cardiovascular disorders

Atrial fibrillation (AF) with coronary artery disease (CAD) requiring percutaneous coronary intervention (PCI) - including both acute and chronic presentations - is common, yet the optimal antithrombotic regimen remains unclear. This study…

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Negative / Null Result ReportMedicine

Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience.

Heidtmann, Umbreit, Eckoldt · 2026 · Journal of pediatric urology

Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term…

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Negative / Null Result Report

Are There Statistically Impenetrable Contexts?

Kent Olson · 2022 · International Journal of Science and Research Methodology

Bayesians claim that reason is conducted according to the axioms of probability. In addition, to this, they claim that Bayesian methodology gives us an account of the scientific method―an account that describes the actual practice of…

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Negative / Null Result Report

ODP648 MEN1 vs MEN4: when we cannot find a mutation

Ricardo Correa, Grishma Sheth · 2022 · Journal of the Endocrine Society

Abstract MEN1 is an autosomal dominant syndrome characterized by involvement of several endocrine and non-endocrine organs. The most common endocrine organs that are affected include pituitary, parathyroid, and/or pancreas. In 10-30% of…

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Negative / Null Result Report

MCorrSeqPerm: Searching for the Maximum Statistically Significant System of Linear Correlations and its Application in Work Psychology

Katarzyna Stapor, Grzegorz Kończak, Damian Grabowski et al. · 2025 · Applied Psychological Measurement

The paper addresses the problem of detecting a statistically significant subset of input considered relationships. The Pearson linear correlation coefficient calculated from a sample was used to determine the strength of a relationship.…

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Negative / Null Result Report

Revelation of Significant Fake Rhetorical in Wrapping Bygone Utilizing Significant Learning Procedures

N. Pughazendi, T. S. Suganya, Soorya S. et al. · 2023 · International Journal on Recent and Innovation Trends in Computing and Communication

The developing computation control has made the profound learning calculations so powerful that making an unclear human synthesized video famously called a profound fake has got to be exceptionally straightforward. Scenarios where these…

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Negative / Null Result Report

Switch to generic formulation of temozolomide results in statistically significant increase in grade 3 and 4 bone marrow toxicity in glioma patients in the province of Alberta

Egiroh Omene, Omar Abdel-Rahman, Eugene Batuyong et al. · 2023 · Neuro-Oncology Practice

Abstract Background Temozolomide (TMZ) is an oral, systemic chemotherapy used chiefly for treating high-grade glioma. Due to the rising costs of systemic chemotherapy, many jurisdictions have replaced brand name with generic formulations.…

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Negative / Null Result Report

Abstract P142: A Statistically Significant Reduction in Heart Failure Length of Stay: Moving the Mean Through Process Improvement

Carolyn M Moffa, William Weintraub, Rocco A DeMaio et al. · 2011 · Circulation: Cardiovascular Quality and Outcomes

Background: The burden of acute heart failure (HF) remains formidable. Length of stay (LOS) must be minimized to control costs, while still maintaining positive outcomes. Inappropriate diagnoses and the lack of coordinated care remain…

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Negative / Null Result Report

Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes

Douglas E. Barre, Kazimiera A. Mizier-Barre, Odette Griscti · 2025 · Endocrine Regulations

Abstract Objective. The objective of the present study was to determine if there would be statistically significant differences among apolipoprotein E genotypes in the responsiveness of members of a cluster of seven measures in persons…

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Negative / Null Result Report

Dysregulation of LYN Gene Expression in Melanoma Patients: A Statistically Significant Association with Clinical Outcomes

Maryam Khalid, Sadia Tameez Ud Din, Mumtaz Hussain et al. · 2025 · South Eastern European Journal of Public Health

Skin cancer accounts for one-third of all diagnosed cancers, with 132,000 new cases of melanoma detected each year (1). By 2040, the melanoma burden is projected to reach 510,000 new cases (a 50% increase) and 96,000 deaths (a 68%…

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Negative / Null Result ReportOpen accessMedicine

Study preregistration: an early example and analysis.

Wiseman R, Watt C · 2026 · PeerJ

Preregistration is commonly seen as an effective way of reducing questionable research practices within psychology. This procedure happens prior to data collection/analysis and usually involves either sending in a research plan to a study…

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Negative / Null Result Report

Apathy - where do we find it and how to treat

R. Gomes, C. Santos, N. Descalço et al. · 2022 · European Psychiatry

Introduction Although defined heterogeneously within the literature apathy is classified as a multidimensional deficit with emotional, behavioral, and cognitive domains in which there is a decrease in self-motivated/goal-directed activity.…

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Negative / Null Result Report

Can education quality be statistically measured?

Ekaterina Bagrova, Sergei Kruchinin · 2021 · SHS Web of Conferences

Currently there are many theories about quality education. The paper presents some of them. It also includes some points of Deming’s philosophy and statistical indicators implemented to determine lecturers’ achievements in Russian higher…

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