Negative / Null Result ReportMedicine
Cherenack EM, Larson ME, Roach ME et al. · 2026 · Brain, behavior, and immunity
Background Limited research has examined the longitudinal interplay of depression, substance use, and immune dysregulation among men with HIV. Methods We analyzed longitudinal data from 100 men who have sex with men (MSM) living with HIV…
View details →Negative / Null Result ReportOpen accessMedicine
Hoehne C, Rehling S, Schrenker J et al. · 2026 · Scientific reports
Preclinical simulation is essential for students to practice before clinical treatment. A low-cost 3D-printed model was developed with repositionable mobile maxillary anterior teeth to train periodontal splinting and evaluate learner…
View details →Failed Experiment ReportOpen accessMedicine
Bolder R, King SBS, Zahn RC et al. · 2026 · Vaccines
Background/objectives RSV is a major cause of mortality in infants, and despite recent progress to prevent RSV in the very young, an RSV vaccine for this population is still highly warranted. Clinical studies in infants in the 1960s using…
View details →Failed Experiment Report
Noble C, Geller D, Urs N et al. · 2026 · Preprint
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become defining therapies in the management of type 2 diabetes and obesity. Despite recent interest in the effects of GLP-1RA therapy on skeletal muscle, their influence on muscle…
View details →Failed Experiment ReportOpen accessMedicine
· 2006
Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…
View details →Negative / Null Result ReportOpen accessMedicine
Tozawa R, Ishii N, Minamoto Y · 2026 · Cureus
Background Medial meniscus extrusion (MME) is a pivotal biomarker for knee osteoarthritis progression. Although ultrasonography offers a dynamic and cost-effective MME assessment, its clinical utility is often limited by the perceived high…
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Stein A · 2026 · Preprint
Abstract Low-dose radiation epidemiology is contested and inconclusive: confidence intervals span zero, and point estimates shift with the chosen dose range. Part of the contest is structural, not empirical. Under the linear…
View details →Negative / Null Result ReportOpen accessMedicine
Arslan SG, Gultekinler BD · 2026 · BMC sports science, medicine & rehabilitation
Background Force platforms are widely used to assess postural stability and vertical jump performance, yet their cost and limited portability restrict routine clinical and field-based use. The Meloq EasyBase force platform offers a…
View details →Failed Experiment ReportOpen accessMedicine
McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations
Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…
View details →Methods Dead-EndOpen accessMedicine
Carroll M, Gao Z, He L · 2026 · Foods (Basel, Switzerland)
Trace quantifications of arsenic (As) in foods by energy-dispersive X-ray fluorescence (ED-XRF) spectrometry are hindered by spectral overlap from lead (Pb) at characteristic emission lines. This study employed artificial neural networks…
View details →Methods Dead-End
De Laender F, Gonzalez A, Bleeckx O et al. · 2026 · Preprint
We provide a general theoretical explanation for a longstanding result in spatial ecology: weak dispersal among habitat patches promotes local biodiversity. Using analytical approximations of spatial Lotka–Volterra competition models, we…
View details →Methods Dead-EndOpen accessMedicine
Zips N, Kulko E, Kath-Schorr S · 2026 · Chembiochem : a European journal of chemical biology
mRNA translation can be controlled through chemical modification of the 5'-Cap, yet systematic insights into structure-reactivity relationships of bioorthogonally activatable Cap analogues remain limited. Here, we report the synthesis of…
View details →Negative / Null Result ReportOpen accessMedicine
Strauss R, Wafula ST, Kobbe R et al. · 2026 · Open forum infectious diseases
We assessed baseline C-reactive protein (CRP) and procalcitonin levels in asymptomatic individuals from malaria-endemic West Africa. C-reactive protein remained unaffected by Plasmodium falciparum parasitemia, while procalcitonin (PCT) was…
View details →Negative / Null Result Report
Bongulto K, Tauchi H, Suzuki S et al. · 2026 · Preprint
Carbapenem-resistant Acinetobacter (CRA) has been associated with increased morbidity and mortality in clinical settings. In this study, we explored the transfer potential of a mobilizable plasmid-harboring blaOXA-72 gene between…
View details →Negative / Null Result Report
Hubbe M, Eibl RH · 2026 · Preprint
Leukocyte recruitment from blood into tissues involves sequential adhesive steps, including rolling and integrin-dependent arrest. VLA-4 can support firm adhesion and, in some settings, rolling interactions, whereas CD44–hyaluronan…
View details →Methods Dead-EndMedicine
La Vignera S, Condorelli RA · 2026 · Diagnostics (Basel, Switzerland)
Normogonadotropic azoospermia (NOAN) represents a diagnostic and therapeutic challenge in male infertility, affecting men with normal gonadotropin levels but absent sperm in the ejaculate. Emerging evidence has identified…
View details →Methods Dead-EndMedicine
Anam C, Amilia R, Naufal A et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Purpose This study aims to evaluate statistical low-contrast detectability (SLCD) at multiple confidence levels (CLs) in computed tomography (CT) images and to determine the smallest detectable object sizes compared with human observers…
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Aguettaz AK, Arribat Y, Schmitt A et al. · 2026 · Preprint
Perilipin 3 (PLIN3) is a lipid droplet–associated protein implicated in cellular lipid metabolism. We characterize a previously unrecognized alternative splicing event in human PLIN3 . The generated transcript PLIN3B is detectable at the…
View details →Negative / Null Result Report
Kakizaki J, Widada AA, Ichihashi N et al. · 2026 · Preprint
The emergence of heritable molecular information is a fundamental step in the origins of life. Prior to the evolution of defined self-reproducing RNAs in the RNA world hypothesis, mixtures of primordial oligonucleotides may have supported…
View details →Negative / Null Result ReportOpen accessMedicine
Loghin II, Vaţă A, Rusu ȘA et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives. Mother-to-child transmission (MTCT) or vertical transmission of human immunodeficiency virus (HIV) is largely preventable in settings where prevention of MTCT (PVT) strategies are consistently implemented.…
View details →Negative / Null Result Report
Pisani M, Marcheschi P, Clemente A et al. · 2026 · Preprint
Aortic calcification represents a key marker of cardiovascular disease, detectable through medical imaging. This research investigates the use of artificial intelligence (AI) to assist radiologists in identifying aortic calcification in…
View details →Negative / Null Result Report
Liang A, Veetil S, Groom K et al. · 2026 · Preprint
Abstract Laser Powder Bed Fusion (LPBF) is a widely adopted additive manufacturing technique for producing geometrically metal components. While this process yields fine microstructures beneficial for strength, the associated rapid thermal…
View details →Negative / Null Result ReportMedicine
Ware A, LaMountain J, White RC et al. · 2026 · Nature communications
The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…
View details →Negative / Null Result ReportOpen accessMedicine
Ajibola G, Nelson BS, Niesar A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Broadly neutralizing antibodies (bNAbs) are a promising treatment option for children with HIV-1, but their long-term impact on virologic, immunologic, and clinical outcomes is unknown. Methods The Tatelo Study investigated dual…
View details →Negative / Null Result ReportOpen accessMedicine
· 2006
Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use,…
View details →Negative / Null Result Report
Reid L, Ganapathiraju S, Mancinelli S et al. · 2026 · Preprint
Retinoid-related orphan receptor gamma (RORγ) is a lineage-defining transcription factor for T helper 17 (Th17) cells and has long been considered selectively expressed within the immune system. However, accumulating evidence has…
View details →Negative / Null Result ReportMedicine
Palenchar PM · 2026 · PloS one
Understanding how evolution shapes variability in gene expression is complicated by the interdependence of expression levels, expression variability, and evolutionary rates. Metrics that quantify variability independently of expression…
View details →Negative / Null Result ReportOpen accessMedicine
Senise G, Bodega F, Porta C et al. · 2026 · Cells
Cigarette smoke is a major inducer of oxidative stress, promoting reactive oxygen species (ROS) accumulation and contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung cancer. Heated tobacco products…
View details →Negative / Null Result ReportOpen accessMedicine
· 2006
Infants receive citalopram in breastmilk, and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and…
View details →Negative / Null Result Report
Li B · 2026 · Preprint
The Standard Model describes particle phenomena through continuous gauge structures, chiral assignments, color, generations, and Yukawa masses, but it does not derive these labels from a deeper structural principle. This paper proposes a…
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