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WASTE Journal

Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication FailureOpen accessMedicine

Serum magnesium levels of children living with sickle cell anaemia at the Lagos University Teaching Hospital: a comparative cross-sectional study.

Akowundu PK, Salako AO, Akinsete AM et al. · 2025 · BMC pediatrics

Background Sickle cell anaemia (SCA) is a lifelong, chronic haemolytic disorder with episodic vaso-occlusive crises (VOC) and chronic end-organ damage. Red cell dehydration during a VOC changes permeability with loss of potassium and…

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Replication FailureOpen accessMedicine

Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study "No One Alone-Gesida Study".

Blanco JR, Albendin-Iglesias H, Negredo-Puigmal E et al. · 2025 · PloS one

Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic…

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Replication FailureOpen accessMedicine

Prevalence and concomitance of diabetic peripheral sensory neuropathy and lower limb peripheral arterial disease in type II diabetics and its correlation with obesity.

Solanki JD, Shah AP, Lalwani N et al. · 2025 · Journal of family medicine and primary care

Introduction Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their…

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Negative / Null Result ReportMedicine

Association between exposure to pyrethroids and chlorpyrifos at age 5 years and IQ at age 7 years among children from the Odense Child Cohort, a prospective birth cohort study.

Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental research

Background Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults…

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Negative / Null Result ReportOpen accessMedicine

Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans.

Gao Y, Hsu V, Kil A et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.…

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Negative / Null Result ReportMedicine

It is time to appreciate the value of processed foods

Fitzgerald M · 2024 · Trends in Food Science & Technology.

The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…

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Replication FailureOpen accessMedicine

Lack of association between <i>MALAT1</i> rs591291 and rs3200401 polymorphisms and venous malformation risk in the Chinese pediatric population.

Lin X, Ou J, Wu G et al. · 2025 · Biochemistry and biophysics reports

Introduction Venous malformations are the most common congenital vascular anomaly, accounting for 65 % of all congenital vascular abnormalities. This study aims to investigate the correlation between genetic polymorphisms of MALAT1 and the…

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Negative / Null Result ReportOpen accessMedicine

Genital tract infections, antiretroviral treatment and HIV-1 viral load in early postpartum women: : implications for sexual and breastfeeding HIV transmission.

Govender V, Govender K, Moodley D · 2026 · BMC infectious diseases

BACKGROUND: Maintaining viral suppression in the postpartum period is critical for preventing HIV transmission to sexual partners and breastfed infants. Despite systemic viral suppression, genital HIV shedding may still occur in some…

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Negative / Null Result ReportMedicine

Lack of Association of Chronological Age and Antithrombotic Agents With Acute Intracranial Hemorrhage in the Group of Older Adults With Traumatic Brain Injury.

Kambara M, Ikawa F, Hidaka T et al. · 2025 · Neurosurgery

Background and objectives Some reports suggest that older patients with traumatic brain injury (TBI) are more likely to experience acute intracranial hemorrhage, resulting in poor outcomes. However, the association between precise…

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Negative / Null Result ReportMedicine

Lack of Association Between Hemoglobin A1c and Continuous Glucose Monitor Metrics Among Individuals with Prediabetes and Normoglycemia.

Rodriguez JA, Palermo NE, Song W et al. · 2026 · Diabetes technology & therapeutics

Continuous glucose monitors (CGMs) are becoming increasingly available, yet the relationship between CGM metrics and hemoglobin A1c (HbA1c) among individuals with prediabetes and normoglycemia remains unclear. We examined associations…

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Negative / Null Result ReportOpen accessMedicine

Age predominates as associate than reproductive health stage for 5 min heart rate variability in middle aged women- a cross-sectional study from Gujarat, India.

Solanki JD, Joshi DR, Atodaria KA et al. · 2025 · Journal of family medicine and primary care

Introduction Cardiovascular health is adversely affected by menopausal transition with reduced heart rate variability (HRV) as a manifest. Electrocardiogram (ECG) based 5 min HRV has worsening trend from premenopausal to postmenopausal…

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Negative / Null Result ReportOpen accessMedicine

Association of immune checkpoint inhibitor-induced bullous pemphigoid with underlying cancer type: A lack of association with cancer tissue <i>COL17A1</i> mutations and dysregulation.

Chang RC, Olbrich H, Wang YF et al. · 2026 · JID innovations : skin science from molecules to population health

Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies to collagen type 17 ( COL17A1 ) and is a recognized immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs). We…

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Negative / Null Result ReportOpen accessMedicine

Associations of cord blood biomarkers with infant colic and excessive crying.

Simonin EM, Switkowski KM, Rifas-Shiman SL et al. · 2026 · Frontiers in pediatrics

Introduction There are currently no known biomarkers associated with the diagnosis of infant colic, a common early disorder of gut brain interaction (DGBI) that has been found to predict adverse health outcomes, including atopy, migraines…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between revision ACL reconstruction and preoperative, intraoperative and post-operative factors at primary ACL reconstruction in children and adolescents.

Cristiani R, Hansson F, Senorski EH et al. · 2025 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To evaluate factors associated with revision anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR in children and adolescents. Methods Children and adolescents (age Results A total of 1888 patients (mean…

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Negative / Null Result ReportOpen accessMedicine

Analyses of haplotypes of <i>TLR2</i> and <i>TLR3</i> genes for COVID-19 prognosis in a cohort of professionals who worked in the first pandemic wave in Belém-PA, Brazil.

Silva MJA, Figueira LRT, Sardinha DM et al. · 2025 · Frontiers in genetics

Coronavirus disease 2019 (COVID-19) is a multisystemic disease caused by SARS-CoV-2 that can lead to several pulmonary illnesses according to the immunological contexts of the individual. Haplotypes consist of single-nucleotide…

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Negative / Null Result ReportMedicine

Plasma Inflammatory Biomarkers Lack Strong Association With Cognitive Outcomes Among Young Adults With Perinatal HIV Exposure and/or Acquisition.

McHenry MS, Huo Y, Williams PL et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or…

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