Negative / Null Result ReportOpen accessMedicine
Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
View details →Negative / Null Result ReportOpen accessMedicine
Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
View details →Negative / Null Result ReportOpen accessMedicine
Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
View details →Negative / Null Result ReportOpen accessMedicine
Kreko-Pierce T, Chen L, Qu G et al. · 2026 · Membranes
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex…
View details →Negative / Null Result Report
Bracci EL, Barnett AG, Brown C et al. · 2023 · Preprint
Background: Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for Appropriate Care…
View details →Negative / Null Result ReportOpen accessMedicine
Krittaphol W, Martin LW, Walker GF et al. · 2025 · Pathogens (Basel, Switzerland)
Chronic infections of Pseudomonas aeruginosa are commonly treated with tobramycin. During infections, the bacteria can exist under conditions of oxygen deprivation that render them less susceptible to this antibiotic. The aims of this…
View details →Negative / Null Result ReportOpen accessMedicine
Newman MS, Smeaton J · 2025 · Menopause (New York, N.Y.)
Objectives 3,3'-diindolylmethane (DIM) is a supplement, investigational drug, and the primary in vivo product of indole-3-carbinol. DIM is sometimes recommended to postmenopausal women by functional or integrative medicine providers. Some…
View details →Negative / Null Result ReportOpen accessMedicine
Vega-Trejo R, Sanghvi K, Todorova B et al. · 2024 · Scientific reports
Mate availability and social information can influence mating behaviour in both males and females. Social information obtained from conspecifics can influence mate choice, particularly shown by studies on mate choice copying. However, the…
View details →Negative / Null Result ReportOpen accessMedicine
Hemmingsen MG, Zhang GF, Ma Y et al. · 2025 · JCI insight
Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during…
View details →Failed Experiment ReportOpen accessMedicine
Tokushige A, Akasaki Y, Shibata K et al. · 2026 · Nutrients
Background/objectives We aimed to evaluate the efficacy and safety of a short-term dietary intervention using trigonelline-rich Sakurajima radish on vascular endothelial function in patients with metabolic syndrome (MetS). Methods In this…
View details →Failed Experiment ReportOpen accessMedicine
Henriksen IW, Bartholdy C, Koch J et al. · 2026 · Clinical and translational science
Valid pre-clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low-to-moderate inflammatory responses with significant variability, undermining…
View details →Failed Experiment ReportOpen accessMedicine
Keith DS, Lessmann E · 2024 · Annals of transplantation
BACKGROUND Mechanical preservation (MP) of deceased donor kidney transplants showed a 30% to 50% reduction in delayed graft function (DGF) as defined by dialysis in the first week, when compared with cold storage. DGF is associated with…
View details →Negative / Null Result ReportOpen accessMedicine
Beirowski B, Huang H, Babetto E · 2026 · eLife
Axon degeneration (AxD), accompanied by glial remodeling, is a pathological hallmark of many neurodegenerative diseases, leading to the disruption of neuronal connectivity. Understanding the mechanisms in neurons and glia that regulate AxD…
View details →Negative / Null Result ReportOpen accessMedicine
Levin ME, Mukasa MN, Bowers EM et al. · 2025 · Behavioral sciences (Basel, Switzerland)
Adherence challenges are common among digital mental health interventions (DMHIs). Single-session DMHIs may help by providing a low-intensity intervention that takes less time to complete. This pilot randomized controlled trial sought to…
View details →Negative / Null Result ReportOpen accessMedicine
Lunde P, Finbråten HS, Pripp AH et al. · 2025 · International journal of cardiology. Cardiovascular risk and prevention
Background and aims Adherence to treatment is a significant challenge for patients with cardiac disease. Optimizing health literacy (HL) is essential in this context. Mobile health (mHealth) interventions have been suggested to improve…
View details →Negative / Null Result ReportOpen accessMedicine
Ferro M, Cilla S, Macchia G et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background This study investigates the impact of radiotherapy (RT) on fatigue levels in prostate cancer (PC) patients, considering the significant physical and psychological impact of fatigue associated with cancer and its treatments.…
View details →Failed Experiment ReportMedicine
Liu Z, Zhao H, Chen X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene
Hormonal stimulation was performed on Japanese black prepubertal calves (8- and 12-month-old) and heifers (2-3-year-old), followed by oocyte retrieval by ovum pick-up (OPU) and in vitro fertilization (IVF). Both calves and heifers…
View details →Failed Experiment ReportMedicine
Schrag A, Embleton-Thirsk A, Carroll C et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)
Pilot randomised-controlled trial of nortriptyline and escitalopram compared to placebo for depressive symptoms in people with Parkinson's disease (PD). Participants with PD and depressive symptoms received either nortriptyline,…
View details →Negative / Null Result Report
stocker t · 2026 · Preprint
Hyperlactatemia, and/or lactic acidosis, is a common complication in wildlife due to the sensitivity of these species to capture induce complications. The treatment of lactic acidosis in humans is equally as controversial as in veterinary…
View details →Negative / Null Result ReportOpen accessMedicine
Warren WG, Papagianni EP, Hale E et al. · 2022 · Frontiers in pharmacology
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can…
View details →Negative / Null Result ReportOpen accessMedicine
Khalid E, Vijayan MM · 2025 · Frontiers in endocrinology
Introduction Although the Crh-Crhr1 system is the proximal trigger for the stressor-induced corticosteroid release, its role in initiating the fight-or-flight response to an acute stressor is unclear. We hypothesized that the Crh-Crhr1…
View details →Negative / Null Result ReportOpen accessMedicine
Ouerghi N, Abassi W, Jebabli N et al. · 2026 · Sports (Basel, Switzerland)
The study investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness, hormonal, and psychological markers in adolescents. Twenty-eight healthy male adolescents were randomized to a HIIT group or a…
View details →Negative / Null Result ReportOpen accessMedicine
Toledo FV, Meletti JFA, Silva LMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)
Introduction Surgery remains one of the most important treatments for breast cancer. In this context, the quality of postoperative recovery has become a key concern. Adequate control of acute pain is essential to optimize patient comfort…
View details →Negative / Null Result ReportMedicine
Salihu AT, Usman JS, Hill KD et al. · 2023 · Experimental brain research
The ability to control balance and prevent falls while carrying out daily life activities may require a predominantly controlled (cognitive) or automatic processing depending on the balance challenge, age, or other factors. Consequently,…
View details →Negative / Null Result ReportOpen accessMedicine
Tatsuoka Y, Zembrzuski KJ, Natalini JG et al. · 2025 · Journal of clinical medicine
Background: Primary graft dysfunction (PGD) is the leading cause of early mortality after lung transplantation. Albumin is commonly used during lung transplantation to maintain intravascular volume while minimizing total intravenous fluid…
View details →Negative / Null Result ReportOpen accessMedicine
Berge M, Hultgren O, Hugosson S et al. · 2026 · Scientific reports
There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently no reliable biomarkers to predict which patients are likely to benefit from the…
View details →Negative / Null Result ReportOpen accessMedicine
Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…
View details →Negative / Null Result ReportOpen accessMedicine
Jobson I, Vo NTN, Kujawinski E et al. · 2025 · Bioelectronic medicine
Background In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocure™, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they extend median…
View details →Negative / Null Result ReportOpen accessMedicine
Johnson KV, Steenbergen L · 2025 · Npj mental health research
The burgeoning field of the microbiome-gut-brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more…
View details →Failed Experiment ReportOpen accessMedicine
Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal
Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…
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